37 results about "Methylprednisolone aceponate" patented technology

The invention discloses a methylprednisolone production device, which comprises a reaction kettle, an elutriation kettle, a centrifugal filtration device, a concentration kettle, a decoloration kettle, a biological fermentation tank and a drying device which are connected in sequence, wherein the drying device comprises an outer cylinder, a drying cylinder and an inner cylinder; a motor is arranged on the bottom surface of the outer cylinder; an exhaust fan blade, a cylinder type impeller and a vortex impeller are arranged on a motor rotating shaft; the exhaust fan blade is arranged between the drying cylinder and the bottom surface of the outer cylinder; the cylinder type impeller is arranged between the drying cylinder and the inner cylinder; the vortex impeller is arranged at the bottomof the inner cylinder; an infrared heating pipe is arranged on the top surface of the inner cylinder; a feeding port is formed in the center of the upper end of the inner cylinder; the side wall of the outer cylinder comprises an inner layer wall and an outer layer wall; an annular interlayer cavity is formed between the inner layer wall and the outer layer wall; an annular baffle is arranged atthe outlet of the upper end of the interlayer cavity, a vent is formed in the baffle, and a rotatable air purification ring is arranged at the upper end of the baffle. According to the method, the preparation time of intermediate products in the production process of the methylprednisolone can be reduced, and rapid and high-quality production of the methylprednisolone can be realized.

The invention relates to hormone cream with methylprednisolone aceponate as active constituent. The invention consists of following materials: solid matter as oil phase substrate, consistency adjusting agent, moisturizer, emulsifier, stabilizing agent and the balance water. The active constituent is dispersed in the cream as water suspension, and suspension assistant should be added in the water suspension.

The invention belongs to the field of pharmaceutical preparations, and relates to a glucocorticoid drug tablet and a preparation method thereof. The raw material medicine of the tablet is methylprednisolone having a particle size of D90 30-40 [mu]m, and the preparation method comprises the following steps: the raw material medicine is pulverized by air flow, and then uniformly mixed with a filler,a disintegrating agent and a lubricant, and then a mixture compressed to obtain a finished product. The glucocorticoid drug tablet prepared by the method has the advantages of high dissolution rate and high stability, and the preparation process improves preparation efficiency, reduces equipment energy consumption, and is suitable for industrial large-scale production.

The invention relates to an adjuvant-containing methylprednisolone aceponate separation type water suspension agent drug for treating skin diseases. The drug comprises methylprednisolone aceponate and water, wherein the packing manner of the methylprednisolone aceponate adopts the individual packing, the methylprednisolone aceponate contains one or a plurality of skin medicine adjuvants, and is insoluble, the D90 particle size is 0.1-10 mum, and the packing manner of the water adopts the individual packing.

Belonging to the technical field of pharmaceutical preparations, the invention relates to a microemulsion preparation of methylprednisolone aceponate and a preparation method thereof. The microemulsion preparation of methylprednisolone aceponate is composed of the following components by mass: 0.01-1% of methylprednisolone aceponate, 10%-30% of a surfactant, 15-40% of a cosurfactant, 10-20% of an oil phase, and the balance water. The preparation method includes: mixing the oil phase, the surfactant and the co-surfactant evenly, adding methylprednisolone aceponate, conducting stirring for dissolving, then adding water, and performing stirring to obtain the microemulsion. According to the invention, methylprednisolone aceponate is made into a microemulsion state, and the dissolvability of methylprednisolone aceponate in the matrix is increased so as to make methylprednisolone aceponate highly diffusive, thus improving bioavailability. Also, the microemulsion has smaller particle size, is isotropic and more uniform, belongs to the homodisperse system, and has more excellent thermodynamic stability.

The invention provides a methylprednisolone aceponate anhydrous crystal form I. Characteristic peaks exist when the X-ray powder diffraction angle 2theta of the crystal form I is equal to 12.8 degrees, 14.2 degrees, 15.8 degrees, 19.7 degrees and 20.2 degrees. The preparation method of the crystal form I comprises drying methylprednisolone aceponate monohydrate to obtain the methylprednisolone aceponate crystal form I. According to the invention, the methylprednisolone aceponate in the anhydrous crystal form I is prepared as a raw material medicine, the raw material medicine of the crystal form is more stable, and after the anhydrous crystal form I of the methylprednisolone aceponate is used for preparing cream, the cream is more uniform, good in dispersion state, high in safety and stablein absorption.

The invention provides a preparation method for 6β-methylprednisolone, using hydrocortisone as a reaction starting material, through methylene reaction, reduction reaction, and dehydrogenation reaction to prepare 6β-methylprednisolone, comprising the following steps (1) methylene Reaction: Hydrocortisone reacts with an alkylating agent at a temperature of 0-50°C under the condition of a catalyst, then reacts with formaldehyde and N-methylaniline, and adjusts the pH value of the acidic condition to 1-2, and obtains methylene intermediate; (2) reduction reaction: under the catalysis of palladium carbon and monophosphite ligand, methylene intermediate reacts with cyclohexene heating to prepare the reduced product; (3) dehydrogenation reaction: the Reduction and dehydrogenation reagent, heat reflux reaction, 6β methylprednisolone. The beneficial effect of the present invention is that by adding a catalyst in the reduction reaction, 6β-methylprednisolone can be prepared through three steps of chemical reactions.

The invention provides a methylprednisolone aceponate monohydrate, a crystal form and a preparation method thereof. The crystal parameters of the methylprednisolone aceponate monohydrate are alpha 90.00, beta 90.00, gamma 90.00, crystal cell volume is that the crystal belongs to a rhombic system, and the space group is P212121. X-ray powder diffraction is used for measurement, the X-ray powder diffraction of the methylprednisolone aceponate monohydrate has characteristic peaks when the diffraction angle 2theta is equal to 8.6 degrees, 12.2 degrees, 13.6 degrees, 15.3 degrees, 18.6 degrees, 19.3 degrees and 20.5 degrees, and the relative diffraction intensity of the methylprednisolone aceponate monohydrate is substantially represented by the detailed spectrogram as figure 2. The methylprednisolone aceponate monohydrate can be prepared by a method of completely dissolving methylprednisolone aceponate in the mixed solution of water and an organic solvent and finally evaporating the organic solvent.

The invention discloses a methylprednisolone aceponate cream preparation, which is characterized by consisting of methylprednisolone aceponate, oil phase matrix, oil phase emulsifier, aqueous phase matrix and aqueous phase emulsifier, wherein the HLB (hydrophile-lipophile balance) value of the oil phase emulsifier is 1.0 to 4.0, the oil phase emulsifier accounts for 2 to 8 percent of the weight of the cream, the HLB value of the aqueous phase emulsifier is 15 to 18, and the aqueous phase emulsifier accounts for 3 to 9 percent of the weight of the cream. The cream preparation has good stability and release degree.

The invention relates to a methylprednisolone sodium succinate powder for injection and a preparation method thereof. The preparation method comprises the following steps: taking methylprednisolone sodium succinate and buffer (or weighing methylprednisolone sodium succinate, buffer and lactose) according to specifications, stirring and dissolving in a water bath less than 50°C with water for injection, After clarification, adjust the pH to 7.4-7.8 with sodium hydroxide solution, and constant volume with water for injection; (2) filter the solution obtained in step (1) with a microporous membrane and pack into vials; (3) divide the step ( 2) Freeze-dry the solution after subpackaging to obtain the methylprednisolone succinic acid freeze-dried powder for injection; the freeze-drying includes pre-freezing, primary drying and secondary drying, and the pre-freezing stage includes annealing operate. The methylprednisolone sodium succinate powder injection prepared by the method has less free methylprednisolone and total impurities, can greatly improve the quality of the medicine, and simultaneously reduce the freeze-drying time and improve the production efficiency.

The invention discloses a methylprednisolone production device, which comprises a reaction kettle, an elutriation kettle, a centrifugal filtration device, a concentration kettle, a decoloration kettle, a biological fermentation tank and a drying device which are connected in sequence, wherein the drying device comprises an outer cylinder, a drying cylinder and an inner cylinder; a motor is arranged on the bottom surface of the outer cylinder; an exhaust fan blade, a cylinder type impeller and a vortex impeller are arranged on a motor rotating shaft; the exhaust fan blade is arranged between the drying cylinder and the bottom surface of the outer cylinder; the cylinder type impeller is arranged between the drying cylinder and the inner cylinder; the vortex impeller is arranged at the bottomof the inner cylinder; an infrared heating pipe is arranged on the top surface of the inner cylinder; a feeding port is formed in the center of the upper end of the inner cylinder; the side wall of the outer cylinder comprises an inner layer wall and an outer layer wall; an annular interlayer cavity is formed between the inner layer wall and the outer layer wall; an annular baffle is arranged atthe outlet of the upper end of the interlayer cavity, a vent is formed in the baffle, and a rotatable air purification ring is arranged at the upper end of the baffle. According to the method, the preparation time of intermediate products in the production process of the methylprednisolone can be reduced, and rapid and high-quality production of the methylprednisolone can be realized.

The invention relates to a methylprednisolone aceponate new crystal form and preparation method thereof. X-ray powder diffraction has characteristic peak at diffraction angle 2theta of 8.6 degrees, 12.2 degrees, 13.6 degrees, 15.3 degrees, 18.6 degrees and 19.3 degrees, and the method that methylprednisolone aceponate is fully dissolved into mixed solution of water and organic solvent, and then the organic solvent is evaporated can be adopted to prepare the new crystal form.