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Methylprednisolone aceponate cream preparation

A technology of methylprednisolone acetonide and cream, applied in the field of medicine, can solve the problems of not fully considering the effect of an emulsifier and being unfavorable for drug absorption and the like

Inactive Publication Date: 2011-02-02
PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent (application number 200710060219.0) discloses a kind of methylprednisolone acetate emulsifiable paste, this patent does not fully consider the effect of emulsifying agent, and insoluble methylprednisolone acetate is prepared into suspension by solubilizer, dissolves in In the matrix of water phase and oil phase, methylprednisolone acetone does not become a molecular state in the matrix, which is not conducive to the absorption of drugs

Method used

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  • Methylprednisolone aceponate cream preparation
  • Methylprednisolone aceponate cream preparation
  • Methylprednisolone aceponate cream preparation

Examples

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Embodiment 1

[0082] A kind of methylprednisolone acetate emulsifiable paste, it is made up of emulsifiable paste by methylprednisolone acetate, oil phase base, oil phase emulsifier, water phase base and water phase emulsifier, wherein oil phase emulsifier HLB value 1.0, oil phase The phase emulsifier accounts for 2% of the cream weight, the water phase emulsifier HLB value is 15, and the water phase emulsifier accounts for 3% of the cream weight.

Embodiment 2

[0084] A kind of methylprednisolone acetate cream, it is made up of methylprednisolone acetate, oil phase base, oil phase emulsifier, water phase base and water phase emulsifier to form emulsifiable paste, wherein oil phase emulsifier HLB value 4.0, oil phase Phase emulsifier accounts for 8% of cream weight, and water phase emulsifier HLB value is 18, and water phase emulsifier accounts for 9% of cream weight.

Embodiment 3

[0086] A kind of methylprednisolone acetate cream, it is made up of methylprednisolone acetate, oil phase base, oil phase emulsifier, water phase base and water phase emulsifier to form emulsifiable paste, wherein oil phase emulsifier HLB value 2.7, oil phase The phase emulsifier accounts for 4.5% of the weight of the cream, the HLB value of the water phase emulsifier is 15.3, and the water phase emulsifier accounts for 5.0% of the weight of the cream.

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Abstract

The invention discloses a methylprednisolone aceponate cream preparation, which is characterized by consisting of methylprednisolone aceponate, oil phase matrix, oil phase emulsifier, aqueous phase matrix and aqueous phase emulsifier, wherein the HLB (hydrophile-lipophile balance) value of the oil phase emulsifier is 1.0 to 4.0, the oil phase emulsifier accounts for 2 to 8 percent of the weight of the cream, the HLB value of the aqueous phase emulsifier is 15 to 18, and the aqueous phase emulsifier accounts for 3 to 9 percent of the weight of the cream. The cream preparation has good stability and release degree.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a methylprednisolone acetate cream preparation. Background technique [0002] Methylprednisolone acetate, chemical name: 21-acetoxy-11β-hydroxy-6α-methyl-17-propionyloxy-1,4-pregnadiene-3,20-dione, clinically used Treatment Treats eczema and psoriasis in adults and children. [0003] Eczema is a common inflammatory allergic skin disease, and the main symptom of eczema is severe itching. The damage of acute eczema is erythema, papule, vesicle, exudate etc., conscious burning hot and pruritus. After a long period of time or after treatment, the acute inflammation is relieved, and the skin lesions are dry and scabbed, entering the subacute stage. Chronic eczema can be caused by repeated attacks in the acute and subacute stages, or it can be chronic at the beginning, and the damage is mainly manifested as skin thickening, rough surface, and pigmentation. It is especially common ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61P17/06A61P17/00A61K31/573
Inventor 顾群金治刚孙学伟徐春霞孙德杰
Owner PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
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