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Oral cavity pasting tablets using Methylprednisolone and derivatives thereof as active components

An active ingredient, methylprednisolone technology, applied in the field of oral stickers to achieve the effect of overcoming potential hazards

Active Publication Date: 2009-02-25
TIANJIN PHARMA GROUP CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And the above-mentioned several plasticizers are mainly used in the packaging of food and medicine in the prior art, but there is no report that they are used as plasticizers in drug coatings.

Method used

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  • Oral cavity pasting tablets using Methylprednisolone and derivatives thereof as active components
  • Oral cavity pasting tablets using Methylprednisolone and derivatives thereof as active components

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] paste sheet

[0028] Methylprednisolone Acetate 0.1g

[0029] Carbomer 10g

[0030] Dextrin 30g

[0031] Magnesium stearate 0.03g

[0032] The protective layer

[0033] 100-55 4g

[0034] Titanium dioxide 1g

[0035] Yellow Iron Oxide 1g

[0036] Acetyl tributyl citrate (ATBC) 0.8g

[0037] Preparation Process:

[0038] Dissolve methylprednisolone acetin with 5ml of absolute ethanol, add the solution of the above active ingredients to the dextrin passed through a 100-mesh sieve, mix well, then granulate through a 30-mesh sieve, dry at 60°C, pass through a 40-mesh sieve For granulation, add carbopol and magnesium stearate passed through a 100-mesh sieve and mix thoroughly, then press into tablets with a flat punch with a diameter of 6 mm to obtain 1000 tablets, each containing 0.10 mg of methylprednisolone acetone. the prescribed amount 100-55 is dissolved in 95ml of 95% ethanol, and the prescribed amount of ATBC, titanium dioxide, and yellow iron oxide is...

Embodiment 2

[0040] The formula of embodiment 1, active component is changed into methylprednisolone acetaminophen 0.2g, plasticizer is changed into tributyl citrate (TBC) other preparation technology is the same as embodiment 1

Embodiment 3

[0042] paste sheet

[0043] Methylprednisolone 0.5g

[0044] Carbomer 5g

[0045] Polyvinylpyrrolidone (PVP) 3g

[0046] Dextrin 30g

[0047] Magnesium stearate 0.05g

[0048] The protective layer

[0049] 100-55 4g

[0050] Titanium dioxide 0.5g

[0051] Trihexyl citrate (THC) 0.8g

[0052] Preparation Process:

[0053] Dissolve methylprednisolone with an appropriate amount of absolute ethanol, add the solution of the above active ingredients to dextrin passed through a 100-mesh sieve, mix well, then granulate through a 30-mesh sieve, dry at 60°C, and granulate through a 40-mesh sieve , add carbomer, PVP, and magnesium stearate that have passed through a 100-mesh sieve, and mix well, then press a flat punch with a diameter of 6 mm to obtain 1,000 tablets, containing 0.5 mg of methylprednisolone. 100-55 was dissolved with 95ml of 95% ethanol, added THC and titanium dioxide in the prescribed amount, ground evenly, sprayed evenly on the surface of the tablet with a...

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PUM

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Abstract

The invention discloses an oral sticking tablet used for treating canker sore of humans or mammals. The oral sticking tablet comprises a sticking layer containing an active ingredient and a water insoluble protective layer, wherein, a non-active ingredient contained in the sticking layer consists of a filling agent, an adhesive sustained-release agent and a lubricant which are applicable to tablets; the water insoluble protective layer is composed of polyacrylic acid resin and / or ethyl cellulose which can be used as protective coating, and a plasticizer; in addition, the active ingredient is methylprednisolone, or one or a combination of pharmaceutically acceptable esters.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition for treating oral ulcers in humans or mammals and its application, in particular to an oral adhesive tablet Background technique: [0002] Oral ulcer is also called recurrent aphtha, is commonly called as aphthous ulcer, is a kind of common oral cavity membrane disease. Recurrent oral ulcers refer specifically to a class of unexplained, recurrent but self-limited, isolated, round or oval ulcers. It is also called recurrent aphthous ulcer (Aphthous is the meaning of "burning and ulceration" in Greek) or recurrent aphthous ulcer. Clinically, it can be divided into three types according to the size, depth and number of ulcers: recurrent mild oral ulcers, recurrent stomatitis ulcers and recurrent necrotizing mucosal periadenitis. [0003] Recurrent oral ulcers are one of the most common diseases in oral mucosal diseases. In people's life, there are almost no oral ulcers that do not occur, but some pe...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/34A61K47/38A61K47/40A61K31/573A61P1/02A61K47/10A61K47/14A61K47/26A61K47/32
Inventor 李静张其婉李宏铃马晓勇姚民芳陈松
Owner TIANJIN PHARMA GROUP CORP
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