Skin drug composition containing methylprednisolone aceponate and amino acid

A technology of methylprednisolone acetate and composition, which is applied in the field of pharmaceutical composition for skin, can solve the problems of great irritation and poor compliance, and achieve the effect of promoting absorption, good absorption and good therapeutic effect

Inactive Publication Date: 2013-06-05
TIANJIN JINYAO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, we found that drugs such as S-methylisothiourea and aminoguanidine, due to their own chemical properties, when used for external use, have greater irritation during treatment, resulting in poor compliance

Method used

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  • Skin drug composition containing methylprednisolone aceponate and amino acid
  • Skin drug composition containing methylprednisolone aceponate and amino acid
  • Skin drug composition containing methylprednisolone aceponate and amino acid

Examples

Experimental program
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Effect test

Embodiment 1

[0033] L-N6-(1-iminoethyl)-lysine 5g, appropriate amount of sodium chloride, sodium carboxymethylcellulose 2.5g, poloxamer 0.5g, methylprednisolone acetate 0.5g, the rest Water for Injection

[0034] Preparation method: Dissolve the carboxymethylcellulose sodium and poloxamer of the prescribed amount in 500ml water for injection, stir to dissolve, add the prescribed amount of L-N6-(1-iminoethyl)-lysine, Adjust the pH to 5.5. Add the prescribed amount of methylprednisolone acetone micropowder, and add the remaining amount of water for injection. Adjust to isotonicity with sodium chloride and dispense. The obtained composition NOS inhibitor %=0.5%, methylprednisolone acetate %=0.05%.

Embodiment 2

[0035] Embodiment 2 gel

[0036] N-monomethyl-L-arginine 10g, glycerol 50ml, carbomer 9342g, methylprednisolone acetate 1g,

[0037] Take the prescribed amount of Carbomer 934 and add glycerol to moisten and grind, add 500ml of purified water to swell as a gel matrix, add the prescribed amount of acepromethylprednisolone micropowder into the gel matrix and stir evenly, and then add the prescribed amount N-monomethyl-L-arginine, dissolved in an appropriate amount of water, slowly added to the gel matrix and stirred evenly, adjusted the pH value to 5.5 with an appropriate amount of 1mol / L sodium hydroxide, and added the rest of the water have to. The obtained composition has NOS inhibitor %=1%, methylprednisolone acetone=0.1%.

Embodiment 2-1

[0039] Prescription is identical with embodiment 2, gets menthol 10g in addition, dissolves in the prescription quantity glycerol, other preparation methods are identical with embodiment 2.

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Abstract

A skin drug composition containing methylprednisolone aceponate and an amino acid comprises the methylprednisolone aceponate which serves as an active ingredient, an amino acid derivative which serves as a nitric oxide synthase (NOS) inhibitor, one or more types of drug auxiliary materials applicable to skin, and the balance water.

Description

technical field [0001] The invention relates to a pharmaceutical composition, which is a pharmaceutical composition for skin containing corticosteroids and amino acids. Background technique [0002] Glucocorticoids have anti-inflammatory, anti-allergic, anti-rheumatic, and immunosuppressive effects, and are widely used in the treatment of allergic and autoimmune inflammatory diseases. Such as connective tissue disease, active rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial asthma, severe dermatitis, ulcerative colitis, acute leukemia, etc. It is also used for some serious infections, poisoning, and malignant lymphoma. treat. [0003] Skin inflammations such as eczema, allergic dermatitis, atopic dermatitis, and urticaria are all allergic reactions caused by certain allergens, resulting in skin inflammation and skin allergies There are many kinds of allergens that react, among which infections such as viruses, fungi, and bacteria are one of the impor...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61K31/198A61P17/00A61P29/00
Inventor 孙亮陈松赵琳
Owner TIANJIN JINYAO GRP
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