Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Uses of methylprednisolone and derivatives thereof in preparing medicament for treating allergic rhinitis

A technology of methylprednisolone and methylprednisolone acetonide is applied in the field of pharmaceutical compositions for the treatment of allergic rhinitis, can solve the problems of telangiectasia, skin atrophy, and high price, achieves avoiding atrophy-causing effect, reducing therapeutic dose, Reduce the effect of systemic effects

Active Publication Date: 2009-01-21
天津药业集团有限公司
View PDF0 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing studies have shown that although halogen-containing glucocorticoids have strong anti-inflammatory activity, the above-mentioned halogen-containing hormones can cause local skin atrophy, telangiectasia and other problems when used externally for a long time
Moreover, due to the difficulty in the synthesis of halogen-containing corticosteroids and the high cost of raw materials, the pharmaceutical preparations for the treatment of allergic rhinitis with the above-mentioned glucocorticoids as active ingredients generally have a higher price.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Uses of methylprednisolone and derivatives thereof in preparing medicament for treating allergic rhinitis
  • Uses of methylprednisolone and derivatives thereof in preparing medicament for treating allergic rhinitis
  • Uses of methylprednisolone and derivatives thereof in preparing medicament for treating allergic rhinitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Methylprednisolone 20mg

[0057] Ephedrine Hydrochloride 0.5g

[0058] Glycerol 5ml

[0059] Carbomer 934 300mg

[0060] 5% ethylparaben ethanol solution 600μL

[0061] Get the prescribed amount of Carbomer 934 and add glycerin to wet and grind, add 50ml of purified water to swell as a gel matrix, and purify the prescribed amount of ephedrine hydrochloride, methylprednisolone, and 5% ethylparaben ethanol solution in 20ml Disperse with water, slowly add to the gel matrix and stir well, adjust the pH value to 6.0 to 7.0 with an appropriate amount of 1mol / L sodium hydroxide, and add purified water to 100ml.

Embodiment 2

[0063] The scheme described in embodiment 1, active ingredient is changed into:

[0064] Methylprednisolone Acetate 25mg

[0065] L-carbastine 20mg

[0066] The dosage of Carbomer 934 was adjusted to 200 mg, other ingredients and preparation method were the same as in Example 1, the prepared pharmaceutical composition was sub-packaged, and the nozzle was installed to obtain the nasal spray gel.

Embodiment 3

[0068] Methylprednisolone Acetone 50mg

[0069] Sodium carboxymethylcellulose 0.4g

[0070] Methylparaben 30mg

[0071] Glycerol 5ml

[0072] Take the prescribed amount of sodium carboxymethyl cellulose, add sodium chloride to 20ml of purified water, stir well and filter, add the prescribed amount of methylparaben into 50ml of purified water, heat to 70°C until completely dissolved, let cool and dissolve the two parts The solution is mixed and added with prescribed amount of methylprednisolone acetone, stirred evenly, the pH value is adjusted to 5.5 to 7.0, and the remaining water for injection is added. Get nasal drops.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

A pharmaceutical composition for treating allergic rhinitis comprises one or a plurality of kinds from methylprednisolone taken as active ingredient or pharmaceutically acceptable salt thereof or esterified matters thereof, and a pharmaceutical composition consisting of one or a plurality of inactive ingredients applicable to local action inside nasal cavity.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition for treating allergic rhinitis. Background technique: [0002] Allergic rhinitis, also known as allergic rhinitis, is an allergic disease of the nasal mucosa and can cause various complications. Allergic rhinitis can occur at any age, both men and women, and it is easy to see in young people. The main reasons are: [0003] (1) Inhalational allergens: such as indoor and outdoor dust, dust mites, fungi, animal fur, feathers, cotton wadding, etc., often cause perennial attacks; plant pollen causes mostly seasonal attacks. [0004] (2) Food allergens: such as fish and shrimp, eggs, milk, flour, peanuts, soybeans, etc. Especially certain drugs, such as sulfonamides, quinine, antibiotics, etc. can cause disease. [0005] (3) Contact objects such as cosmetics, gasoline, paint, alcohol, etc. [0006] Others may be certain bacteria and their toxins, physical factors (such as changes in cold and heat, te...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/573A61K9/00A61K9/06A61K9/12A61K9/70A61K47/38A61K47/44A61P11/02A61P37/08A61K47/32
Inventor 郝于田陈松张乐杨新意
Owner 天津药业集团有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com