The invention discloses a gromwell root and safflower ulcer ointment, which is prepared from the following raw material medicines by weight: 15 to 25g of gromwell root, 15 to 25g of safflower, 8 to 12g of peach kernel, 8 to 12g of hair and 400 to 600g of sesame oil. The gromwell root and safflower ulcer ointment is prepared from four compatible raw material medicines and the sesame oil. Traditional Chinese medicinal active ingredients such as the gromwell root and the safflower are dissolved in an organic solvent of sesame oil, and the gromwell root and safflower ulcer ointment has the effects of promoting blood circulation and removing blood stasis, removing putrid tissues and promoting the growth of new tissues, cooling blood and eliminating stasis, reducing liquid exudation, promoting blood flow of skin capillaries, reviving necrotic tissues and not leaving scars. The gromwell root and safflower ulcer ointment is simple in formula, obvious in treatment effect, and short in treatment course without toxic or side effect. The gromwell root and safflower ulcer ointment can treat symptoms such as bedsore, eczema, burn and scald, cold injury, skin allergy, wound non-healing and the like without scars, has better treatment effect on esophagitis, gastric ulcer and dental ulcer, and also has good effect on gynecological diseases such as cervical erosion, endometritis, intimal hyperplasia and ectopia.