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Multi-structure artificial blood vessel scaffold with inner layer capable of releasing NO gas and preparation method thereof

An artificial blood vessel and multi-structure technology, applied in the medical field, can solve the problems of low drug loading efficiency and achieve the effects of high loading efficiency, convenient operation, and simple preparation

Active Publication Date: 2016-09-28
YANGZHOU NO 1 PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The spinning equipment required by this technology is simple, and the electrospinning process is more stable than coaxial electrospinning, but there are also unavoidable defects: low drug loading efficiency

Method used

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  • Multi-structure artificial blood vessel scaffold with inner layer capable of releasing NO gas and preparation method thereof
  • Multi-structure artificial blood vessel scaffold with inner layer capable of releasing NO gas and preparation method thereof
  • Multi-structure artificial blood vessel scaffold with inner layer capable of releasing NO gas and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] First, 0.1 g of hyaluronic acid (HA) was added to 9.9 g of distilled water, stirred to dissolve it completely, and an aqueous sol with a concentration of 1 wt % was prepared. Take 0.1g of 1wt% hydrosol, add 0.005g of nitrogen alcohol into it, and make it dissolve completely.

[0043] Next, first add 0.01 g of Span-80 (Span-80) to 4 g of dichloromethane (DCM), then slowly add the prepared hydrosol carrying NO substances into it dropwise, and use High-speed stirring on a magnetic stirrer for about 20 minutes, thereby preparing a relatively uniform water-in-oil (W / O) emulsion system containing drug-loaded hydrosol particles.

[0044] Then, 1.0 g of poly-L-lactic acid was added to the emulsion system, and after stirring and dissolving, 2 g of dimethylformamide (DMF) was added, and the stirring was continued to prepare a uniform and stable hydrosol electrospinning solution.

[0045] The electrospinning process is carried out at room temperature, and the experimental equipme...

Embodiment 2

[0047] Embodiment 2: The emulsifier is selected from one or more of Span 80, calcium hydroxide, zinc hydroxide, and magnesium stearate. One or more of chlorobenzene, dichlorobenzene, methylene chloride, dimethylformamide, and triethanolamine.

[0048] First, add 0.1 g of silk fibroin to 9.9 g of distilled water, stir to make it all dissolve, and prepare a hydrosol with a concentration of 1 wt%. Take 0.1g of 1wt% hydrosol, add 0.010g of nitrogen alcohol therein, and make it dissolve completely.

[0049] Next, first add 0.01 g of calcium hydroxide to 4 g of chlorobenzene, then slowly drop the prepared hydrosol carrying NO substances into it, and stir at high speed with a magnetic stirrer for about 20 minutes at room temperature , so as to prepare a relatively uniform water-in-oil (W / O) emulsion system containing drug-loaded hydrosol particles.

[0050] Then, 1.0 g of polyglycolic acid was added to the emulsion system, and after stirring and dissolving, 2 g of dichloromethane w...

Embodiment 3

[0054] First, add 0.1 g of collagen to 9.9 g of distilled water, stir to dissolve it completely, and prepare a hydrosol with a concentration of 1 wt%. Take 0.1g of 1wt% hydrosol, add 0.015g of nitrogen alcohol therein, and make it completely dissolve.

[0055] Next, first add 0.01 g of zinc hydroxide to 4 g of dichlorobenzene, then slowly drop the prepared hydrosol carrying and releasing NO substances into it, and stir at high speed with a magnetic stirrer at room temperature for about 20 Minutes, thereby preparing a relatively uniform water-in-oil (W / O) emulsion system containing drug-loaded hydrosol particles.

[0056] Then add 1.0 g of polylactic acid to the emulsion system, stir and dissolve completely, then add 2 g of triethanolamine, continue stirring, and finally prepare a uniform and stable hydrosol electrospinning solution.

[0057] The electrospinning process is carried out at room temperature, and the experimental equipment includes: a high-voltage DC power supply,...

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Abstract

The invention discloses a multi-structure artificial blood vessel scaffold with an inner layer capable of releasing NO gas and a preparation method thereof. The artificial blood vessel scaffold comprises the inner layer, a middle layer and an outer layer. The middle layer is sleeved with the outer layer. The inner layer is sleeved with the middle layer. The inner layer is made from electrostatic spinning fiber. The electrostatic spinning fiber is formed by mixing hydrosol and substances capable of releasing NO gas. The substances capable of releasing the NO gas are uniformly dispersed in an electrostatic spinning solution of the hydrosol in a wrapping mode, then, the micro-sol electrostatic spinning technology is adopted for constructing the nanofiber small-diameter vessel scaffold, so that a micro-sol electrostatic spinning fiber membrane with the inner layer with the substances capable of releasing NO gas is prepared, and then the multi-structure artificial blood vessel scaffold with the inner layer capable of releasing NO gas is obtained. The method is simple in preparation, convenient to implement, high in drug loading efficiency, and can slowly release NO gas. The thrombus resistance and the effect of restraining intimal hyperplasia are achieved by releasing NO gas.

Description

technical field [0001] The invention relates to the medical field, in particular to a multi-structure artificial blood vessel stent whose inner layer releases NO gas and a preparation method thereof. Background technique [0002] Vascular diseases seriously endanger human health. Every year, tens of thousands of people around the world suffer from vascular diseases due to various reasons such as vascular aging, damage, and disease. Vascular defect repair, especially the repair of small-diameter vessels (inner diameter <6 mm) has always been one of the clinical difficulties. [0003] Embolism is the main cause of failure after small-bore vascular grafts. There are many reasons for embolism, and the mismatch between artificial blood vessel and host blood vessel compliance after implantation is one of the main causes of thrombosis and intimal hyperplasia in small-caliber artificial blood vessels. [0004] At present, artificial vascular stents can effectively solve this pr...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/20A61L27/22A61L27/54A61L27/50
CPCA61L27/20A61L27/222A61L27/225A61L27/227A61L27/24A61L27/507A61L27/54A61L2300/114A61L2300/204A61L2300/42
Inventor 倪庆吴巍赵昕崔文国戴勇万丽萍
Owner YANGZHOU NO 1 PEOPLES HOSPITAL
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