The invention provides a manufacturing method of an interior decoration material capable of eliminating peculiar smell and harmful gas, which adds medical stone powder, diatomite powder, tourmalinite powder, rare earth, and the like into PU resin; The method comprises the following steps: firstly well mixing medical stone powder, diatomite powder, tourmalinite powder, rare earth, and the like, then adding the mixture into a resin material, stirring, defoaming, grinding by a grinding device to obtain slurry, coating surfaces of pvc leather, PU leather materials with the slurry with a coating amount of 200 g / m2, and drying in a drying room to obtain the finished product. When the product is used for decoration in automobile and rooms, the product can emit infrared light with a wavelength of 5-15 microns, can ionize negative ions in air, and has the functions of rapidly eliminating and decomposing peculiar smell such as formaldehyde, benzene, and cigarette smell, and other harmful gas; the product can be used for automobile inner decoration, house interior decoration, and other space decoration, can both beautify space and purify air, has the function of health care, and thus enables people to absorb 'air vitamin' as much as one likes.