30 results about "Hydroxychloroquine sulphate" patented technology

The invention discloses a hydroxychloroquine sulphate solid preparation, which contains hydroxychloroquine sulphate or pharmaceutically acceptable salts thereof and an auxiliary material, wherein the auxiliary material comprises a buffer pair; the buffer pair is dissolved in water to form a buffer solution with pH of 4-6.5; and the content of the buffer pair is 0.05-2% in terms of mass percentage. The invention further discloses a preparation method of the hydroxychloroquine sulphate solid preparation. The hydroxychloroquine sulphate solid preparation disclosed by the invention has excellent dissolution property and stability, and particularly, is obviously increased in stability compared with the prior art.

A method for prevention or treatment of a viral-mediated infectious disease in a mammal. The mammal may be a human being. A therapeutic dose of a composition is administered, via an inhalation delivery apparatus, to the mammal. The composition includes microparticles and / or nanoparticles. The microparticles and / or nanoparticles include a first pharmaceutically active agent and a second pharmaceutically active agent. The first pharmaceutically active agent includes unfractionated heparin (UFH), Low Molecular Weight Heparin (LMWH), sulfated non-anticoagulant heparin (S-NACH) or combinations thereof. The second pharmaceutically active agent includes 10-30 mg of hydroxychloroquine in a form of hydroxychloroquine sulfate, 10-30 mg of favipiravir, or a combination thereof. The viral-mediated infectious disease is caused by one or more viruses in the mammal.

The invention relates to a preparation method of hydroxychloroquine sulfate, and belongs to the technical field of medicine synthesis. According to the preparation method of hydroxychloroquine sulfate, 7-chloro-4-fluoroquinoline and 5-(N-ethyl-N-2-hydroxyethyl amine)-2-pentylamine are subjected to a reaction to prepare hydroxychloroquine, and then hydroxychloroquine and sulfuric acid are salifiedto prepare hydroxychloroquine sulfate. The 7-chloro-4-fluoroquinoline is prepared from 4,7-dichloroquinoline through a halogen exchange reaction. The preparation method of hydroxychloroquine sulfate has the advantages of low reaction temperature, short reaction time, fewer byproducts, simple technique and favorable reproducibility, and is beneficial to industrial production.

The invention discloses a purification method of hydroxychloroquine sulfate, which comprises the following steps: (1) dissolving a hydroxychloroquine sulfate crude product in water or a mixed solventof water and a first solvent to obtain a mixed solution I; (2) adding a second solvent into the mixed solution I, and carrying out reflux crystallization; and (3) cooling the reaction product, and filtering and drying the reaction product to obtain a fine hydroxychloroquine sulfate product. The method is excellent in purification effect, so that hydroxychloroquine sulfate with the purity of 99.5%or above and the particle size Dx (90) larger than or equal to 200 microns is prepared. The method is easy and convenient to operate, low in cost, safe, environmentally friendly and suitable for large-scale production.

The invention provides a chloroquine inhalant and a preparation method thereof, and belongs to the field of medicine preparations. The inhalant comprises chloroquine phosphate or hydroxychloroquine sulfate, a stabilizer and a diluent, can improve use efficiency, has a preventive effect, such as a new epidemic situation-COVID-19, and can take effect quickly. The powder inhalation has better stability, has the effects of masking taste, enhancing stability and protecting organism biological membranes on chloroquine phosphate or hydroxychloroquine sulfate after being wrapped by the stabilizer, is absorbed through the lungs, has a high targeting effect, also can effectively avoid the first-pass effect caused by the liver during oral administration, and improves bioavailability.

The invention relates to a method for detecting hydroxychloroquine sulfate. The method comprises the following steps of 1) preparation of a test sample solution, specifically, taking a hydroxychloroquine sulfate test sample, adding an acetonitrile-water mixed solution, dissolving and diluting; 2) preparation of a reference substance solution, specifically, dissolving a hydroxychloroquine sulfate reference substance in the acetonitrile-water mixed solution, and diluting; and 3) a determination method, specifically, measuring the reference substance solution and the test solution, injecting intoa high performance liquid chromatograph, recording a spectrogram, and calculating the content of the test hydroxychloroquine sulfate according to the peak area, wherein the chromatographic conditionsof the high performance liquid chromatography are as follows that octadecylsilane chemically bonded silica is used as a filler, a mobile phase is a mixed solution of a dipotassium phosphate solutionand acetonitrile in a volume ratio of 10 to 90-70 to 30, the flow rate is 0.8-1.2 ml / min, the detection wavelength is 244-264 nm, and the sample size is 5-50mu l. The method has the advantages of goodin the obtained component spike and resolution, simple in operation, high in precision, high in the recovery rate and good in the stability and repeatability.

The invention discloses a new application of chloroquine for preventing and controlling root-knot nematode, and belongs to the technical field of root-knot nematode prevention and control. The application of chloroquine of the present invention in preventing and treating root-knot nematode and the application of chloroquine in inhibiting root-knot nematode infection, development and / or oviposition, wherein chloroquine is chloroquine phosphate, hydroxychloroquine sulfate or quinine sulfate. Application of chloroquine in the preparation of root-knot nematode insecticide or root-knot nematode infection, development and / or oviposition inhibitor, root-knot nematode insecticide or root-knot nematode infection, development and / or oviposition inhibitor The active ingredient is chloroquine phosphate, hydroxychloroquine sulfate or quinine sulfate, and the root-knot nematode insecticide or root-knot nematode infestation, development and / or oviposition inhibitor is an aqueous solution of chloroquine phosphate, hydroxychloroquine sulfate or quinine sulfate . The invention uses the aqueous solution of chloroquine to prevent and control the root-knot nematode, which is safe, non-toxic and effective.