Method for detecting content of hydroxychloroquine sulfate in artemisinin hydroxychloroquine sulfate tablets

A technology of hydroxychloroquine sulfate and artemisinin, applied in the field of medicine and chemical industry, can solve the problems of low accuracy and precision, and achieve the effects of high precision, high sensitivity and fast measurement speed

Pending Publication Date: 2021-02-23
GUANGDONG NEWSOUTH ARTEPHARM CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The accuracy and precision of the results of these two methods are relatively low

Method used

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  • Method for detecting content of hydroxychloroquine sulfate in artemisinin hydroxychloroquine sulfate tablets
  • Method for detecting content of hydroxychloroquine sulfate in artemisinin hydroxychloroquine sulfate tablets
  • Method for detecting content of hydroxychloroquine sulfate in artemisinin hydroxychloroquine sulfate tablets

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Embodiment 1

[0037] In a specific embodiment, the method for detecting the content of hydroxychloroquine sulfate in artemisinin hydroxychloroquine sulfate tablets comprises the following steps:

[0038] 1. Preparation of standard solution:

[0039] Take 10mg of hydroxychloroquine sulfate reference substance, accurately weigh it, place it in a 100mL measuring bottle, add mobile phase to dissolve and quantitatively dilute to the mark, and make a solution containing about 0.1mg per 1mL.

[0040] 2. Preparation of sample solution

[0041] Take 10 pieces of Artemisinin Hydroxychloroquine Sulfate Tablets, accurately weigh, grind finely, accurately weigh an appropriate amount (approximately equivalent to 10 mg of Hydroxychloroquine Sulfate), put it in a 100mL measuring bottle, add an appropriate amount of mobile phase, and ultrasonically dissolve it for 15 minutes. Cold, dilute to the mark with mobile phase, shake well, filter, that is.

[0042] 3. High performance liquid chromatography detecti...

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Abstract

The invention relates to a method for detecting the content of hydroxychloroquine sulfate in artemisinin hydroxychloroquine sulfate. The method comprises the following steps: performing detecting by using a liquid chromatography under the following detection conditions: an octadecylsilane chemically bonded silica chromatographic column is used as a chromatographic column, the mobile phase is composed of a potassium dihydrogen phosphate solution and methanol, the potassium dihydrogen phosphate solution is used as a mobile phase A, and the methanol is used as a mobile phase B, the volume ratio of the mobile phase A to the mobile phase B is (1-25): (75-99). The method has a good separation degree on hydroxychloroquine sulfate peaks.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, and in particular relates to a method for detecting the content of hydroxychloroquine sulfate in artemisinin hydroxychloroquine sulfate tablets. Background technique [0002] Hydroxychloroquine sulfate (hydroxychloroquine sulfate), trade name Plaquenil. Hydroxychloroquine sulfate is an antimalarial drug, used to control malaria symptoms, suppressive prevention of malaria symptoms, and can also be used for the treatment of lupus erythematosus, rheumatoid arthritis, joint stiffness, arthritis, and oral lichen planus. Properties are white or off-white crystalline powder, odorless or almost odorless, bitter in taste. Soluble in water, almost insoluble in ethanol, chloroform or ether. Its molecular structural formula is as follows: [0003] [0004] At present, hydroxychloroquine sulfate is not recorded in "Pharmacopia of the People's Republic of China", but "United States Pharmacop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/86
CPCG01N30/02G01N30/06G01N30/8679G01N2030/027
Inventor 宋健平邓长生张红英肖飞
Owner GUANGDONG NEWSOUTH ARTEPHARM CO LTD
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