The invention relates to the technical field of automobile logistics, in particular to a multi-target logistics scheduling method and device, a logistics system and a computer readable medium. The method comprises the following steps: S1, initializing an order distribution strategy to form an initial scheduling arrangement; s2, using a target cost function to calculate cost for the initial scheduling arrangement; s3, updating the order distribution strategy and the scheduling arrangement by using a global optimization algorithm; s4, calculating the cost of the updated scheduling arrangement byusing a target cost function to obtain an optimization result of the target cost function, if the optimization requirement is not met, continuing to execute the step S3, and if the optimization requirement is met, executing the step S5; and S5, performing constraint condition inspection on the scheduling arrangement, if the scheduling arrangement passes the inspection, determining the schedulingarrangement to be an optimal result, and if the scheduling arrangement does not pass the inspection, continuing to perform the step S3. The planned route achieves the optimal total route length, and compared with the current logistics actual scheduling arrangement, the number of vehicles is obviously reduced, the loading rate is increased, and the cost is saved.