The invention discloses blasting damaged rock sample preparation and a micro-macro combined damage degree determination method, and belongs to a determination method for a damage degree of a damaged rock sample. The micro-macro combined damage degree determination method comprises the following steps: a, manufacturing a square rock with thickness of 105mm, putting an explosive and a detonator at the geometric center of the rock, adhering resistance strain gauges and acceleration sensors at key points of the rock, and connecting the resistance strain gauges and the acceleration sensors to a super dynamic data acquisition instrument; b, drilling the rock with large blasting fragment size with the key points as circle centers along the thickness direction, polishing standard rock samples, and collecting small irregular rocks; c, performing a mercury injection test on the irregular rocks, and performing CT, nuclear magnetic resonance, longitudinal wave velocity, osmotic coefficient, elasticity modulus and uniaxial compressive strength tests on the blasting damaged standard rock samples; e, performing identical micro-macro tests on homogeneous complete rock samples; and f, based on dynamic strains and acceleration waveforms, quantitatively determining the degree of damage, caused by blasting impact, to a rock material by synthesizing micro-macro test data. The determination method has the advantages of simplicity in operation and comprehensive and reliable test data.