112 results about "Fat body metabolism" patented technology

A method is provided for regulating carbohydrate and fat metabolism is an individual which method comprises replacing a proportion of the individual's daily carbohydrate intake with resistant starch and a proportion of the individual's saturated fat intake with unsaturated fat. Also provided are compositions comprising resistant starch and unsaturated fats and methods for making and using the same

Provided herein are methods for determining the metabolism of one or more sugars and / or fatty acids, and applications thereof. Such applications include determining the rate of glycogen synthesis and glycolysis, which are believed to be early markers for predicting elevated risk of diabetes and cardiovascular disease. Other applications include methods for screening drugs that effect sugar and / or fatty acid metabolism. The methods are useful for at least partially characterizing drugs for desirable or undesirable (toxic) characteristics. Drugs that are at least partially characterized using the methods of the invention can then be further developed in pre-clinical testing and clinical trials. Such drugs may be found to be useful in treating obesity, diabetes, cardiovascular disease, and other disorders of metabolism.

The present invention provides methods and compounds for regulating fat metabolism and achieving fat homoeostasis in a subject. Methods and compound for regulating body weight, reducing body fat, and inducing weight loss are also provided, as are methods and compounds for treating or preventing obesity and for preventing or treating conditions associated with altered fat metabolism including, e.g., obesity, diabetes, atherosclerosis, etc.

The present invention relates to a non-human vertebrate animal model displaying an alteration in fat metabolism or in the sensitivity towards leptin or insulin, which model bears a mutation in the gene encoding the spinster like 1 protein (Spinl1). The invention also relates to mutant Spinl1 proteins and nucleic acid sequences encoding these proteins. Furthermore, the invention relates to the use of the non-human vertebrate animal model for the identification of diagnostic markers, or as a model for studying the molecular and physiological mechanisms associated with an alteration in fat metabolism or an alteration in the sensitivity towards leptin or insulin, or for the identification and testing of agents useful in the prevention, amelioration, or treatment of the above conditions. Agents, pharmaceutical compositions, and methods for treating the above conditions are likewise described, as are methods for identifying said agents.

The invention discloses a health-care beverage of guava. The health-care beverage is characterized by comprising the following substances and materials in parts by weight: 30-50 parts of guava, 20-40 parts of bitter gourd, 10-30 parts of Chinese yam, 20-40 parts of folium mori and 5-20 parts of American ginseng. The health-care beverage can be made into dosage forms of tablets, capsules, granules, tea bags and the like; the health-care beverage tastes good, has the original flavor, has the pleasant tea fragrance, is applicable for long-term drinking of glycosuria patients, has the functions of conditioning the insulin secretion and promoting the glycometabolism and fat metabolism, and is capable of conditioning the physiological functions of glycosuria patients, recovering the normal functions of the spleen and stomach and achieving the functions of blood sugar reduction, fat reduction, and glycosuria adjuvant therapy; and when being drunk or taken by ordinary people, the health-care beverage also has the functions of promoting the human body conditioning ability and ensuring the health.

A formulation for anaesthetic use is described. The formulation contains propofol, and may be used to induce and / or maintain anaesthesia or sedation in a vertebrae. The formulation additionally contains a solvent or a combination of solvents and is suitable for mixing with commonly used infusion fluids prior to injection in to a patient. The formulation may be terminally sterilised using moist heat in order to assure sterility, and contains no lipid, thereby avoiding complications associated with administration over prolonged periods of time, or to patients with disorders of fat metabolism.

The patent relates to a health products having slimming food, which taking natural medicine lotus leaves, aqueous extract of phyllanthus as raw material, adding l-carnitine and mixing them by a certain proportion to forming effervescent and granules. The invention has functions of stopping fat absorption, anti-aging, anti-oxidation and so on and regulating body environment and supplementing natural vitamin, aminophenol and microelement, which is capable realizing losing weight and life-prolonging ideal effect though long-term taking.

The invention discloses a protein solid beverage, which mainly includes protein powder, β-glucan, L-carnitine, β-carotene, vitamin D3, vitamin E, and vitamin B 1 , Vitamin B 2 , niacin, pantothenic acid, vitamin B 6 , folic acid, vitamin B 12 , vitamin C, calcium, magnesium, zinc and chromium. The protein solid beverage of the present invention has a reasonable formula, and solves the problems of obesity, hyperglycemia, hyperlipidemia and hypertension from the aspects of the speed of blood sugar rise, the efficiency of blood sugar burning and utilization, and the efficiency of fat metabolism.

The invention relates to a polypeptide capable of regulating energy metabolism and application of the polypeptide in preparation of medicines for treating diseases related to disorder of energy metabolism (particularly fat metabolism). The polypeptide disclosed by the invention can achieve the effects of reducing fat absorption, lowering fat accumulation in the liver and regulating the fat metabolism; and compared with a general polypeptide product, the polypeptide disclosed by the invention has the advantage of being orally applied. Therefore, the polypeptide can serve as an active ingredient of a health care product used for regulating the fat metabolism.

The present invention relates to a method for preventing and / or treating a fat metabolism disorder and its related conditions, comprising administering an effective amount of plasminogen to a subject susceptible to or suffering from a fat metabolism disorder and its related conditions, to reduce an abnormal fat deposition at various sites of the body, thereby achieving the purpose of preventing and / or treating a fat metabolism disorder and its related conditions or complications.

The invention provides a probiotic composition and a use thereof as well as food and pharmaceuticals. The probiotic composition comprises bifidobacterium breve; lactobacillus rhamnosus; and bifidobacterium lactis. The three bacteria in the probiotic composition disclosed by the invention can synergistically co-generate and promote growth and metabolism, so that the probiotic composition plays a probiotic role in the intestinal tract, reduces inflammation in the body and promotes fat metabolism, thereby achieving the effects of reducing weight and reducing lipid.

The invention discloses a composition for regulating the sub-health status of the crowd suffering from lipodystrophy. The composition mainly has the effects of reducing the expression of the hypothalamic neuropeptide gamma by influencing human leptin, improving the energy metabolism efficiency, increasing the energy consumption and inhibiting fat synthesis. The other components with fat decomposing effects are combined, so that the metabolism of human adipose tissues is promoted, and the intracellular oxidative phosphorylation effect and synthesis of cell endogenous cholesterol are inhibited. The composition can be used for achieving the effects of effectively infiltrating into the human skin, inhibiting the activity of lipase and reducing the synthesis of fat. By combining the traditional Chinese medicine naprapathy, the absorption and intracellular transport of the composition can be further promoted, the metabolism is promoted, the triglyceride in the fat is decomposed, the excretion of steroid and gallic acid is increased, the excretion of cholesterol and other metabolites can be accelerated, a local shaping effect is achieved, and the contents of glycerin and cholesterol in serum are reduced in an assisted mode. The pharmacological action of the cardiovascular system is improved, and the blood circulation is improved.

The present invention relates to soluble dimeric double metal salt compositions of (−)-hydroxycitric acid (“HCA”), as well as methods for making and using the same. The invention provides dimeric double metal salts of group IA and IIA of HCA (hereinafter, “DDM-HCAs”). The present invention provides methods to make DDM-HCAs of the invention which can be employed to alter the polar / ionic qualities of HCA salts and derivatives to improve solubility of HCA compositions. DDM-HCAs of the invention are soluble HCA-containing compositions useful as dietary supplements and suitable for manipulations under those conditions necessary for tabletting, encapsulation, and the production of dry powders, particularly for use as a beverage premix. Methods of use of the composition include treatment for suppression of appetite, for weight loss, for an increase in the rate of fat metabolism, for reduction in blood lipids and postprandial lipemia, and to increase the plasma level of (−)-hydroxycitric acid.

The present invention relates to the technical field of medicine, particularly to an application of a glucosamine salt. The weight reduction and / or fat reduction drug prepared by adopting the glucosamine salt, especially the drug with effects of weight reduction and fat reduction, provides significant application effects in fields of weight control, appetite ensuring, body fat reduction and liver fat metabolism acceleration. Application research results show that the glucosamine hydrochloride provides more excellent corresponding effects compared with the glucosamine sulfate. The present invention provides the new application of the glucosamine salt, wherein the glucosamine salt has effects of significant weight reduction, significant fat reduction, fatty liver alleviating and serum blood fat reduction.

The invention discloses a pure Chinese medicinal composition for hyperlipidemia obesity and a preparation method thereof. The composition comprises the following components in parts by weight: 100 parts of spirulina, 60 parts of baikal skullcap root, 120 parts of rhizoma alismatis, 60 parts of codonopsis pilosula, 60 parts of subprostrate sophora, 120 parts of grifola, 50 parts of folium sennae, and 50 parts of polygonum cuspidatum. The medicinal composition for hyperlipidemia obesity is a pure Chinese medicinal capsule, which can be used for soothing liver-qi stagnation, invigorating spleen and supplementing qi, removing stasis, reducing fat and losing weight and promoting fat metabolism by regulating body performance, so that the effect of treating hyperlipidemia and simple obesity can be achieved. The Chinese medicinal composition has the advantages of high safety, no toxic or side effect, no dependence, stable and controllable quality, simple preparation process and the like, is convenient for carrying and taking and can be produced by virtue of conventional equipment.

The invention provides a feed. The feed comprises corn, fish meal, soybean meal, corn gluten meal, docosahexaenoic acid microalgae powder, beet, trace element additives, vitamin additives, amino acid additives, sodium butyrate, medical stone and traditional Chinese medicine composition feed additives. The feed has the advantages of low price, no toxicity, no residues, safety, convenience, comprehensive functions and the like, and can increase animal nutrition, improve fat metabolism of organisms, reduce deposition of abdominal fat of broilers, promote animal growth and development and improve muscle quality.

A method for making the potassium, sodium and other hygroscopic salts of (−)-hydroxycitric acid and mixtures thereof workable by initial treatment with a desiccating agent, such as fumed silicon dioxide. These may be further rendered non-hygroscopic and non-reactive in acidic media via subsequent encasement in hydrophobic and acidophobic polymers. The calcium and magnesium salts of (−)-hydroxycitric acid likewise can be rendered nonreactive in acidic media. The resulting products are suitable for tableting, encapsulation and use in other dry media for weight loss, appetite suppression, improvements in fat metabolism and postprandial lipemia and other pharmaceutical purposes. Further, the products of this invention can be made nonreactive as components of acidic liquid drink mixes and snack bars and can be used in the production of controlled release administration formats.

A quantitative, non-invasive optical spectroscopy technique for measuring dynamic changes in adipose tissue structure and metabolism in vivo. The technique requires multiple wavelengths of light in the near-infrared (650-1000 nm). Using these wavelengths of light, adipose tissue is illuminated and light that returns to a photodetector is analyzed. From the return signals, the absorption and reduced scattering coefficients (μa and μs′) at each wavelength are calculated. The obtained pa and μs′ values allow for quantification of biomarkers and indices which allow for measurement of fat composition and metabolism. The concentration of oxy- and deoxy-hemoglobin, the fractional water and lipid content, and information about the size distribution of light scatterers in the adipose tissue are also determined. A detailed and quantitative understanding of fat composition and metabolism is thereby provided which describes the effectiveness of interventions to improve the health of a patient.

The invention discloses a feed additive capable of improving an intestinal function of grass carps and application of the feed additive. An effective component of the additive is glycylglutamine; and the adding amount in grass carp feed is 0.25-0.75%. With the adoption of the additive disclosed by the invention, the growth and fat metabolism of the grass carps can be effectively facilitated, and the oxidation resistance of the grass carps is improved; a shape structure of small intestines of the grass carps can be improved; villus height, crypt depth, mucous membrane thickness, the quantity of goblet cells and the quantity of lymphocytes of the intestines are increased; and the secretion of an intestinal digestive enzyme can be accelerated, and the feed additive has active improvement effect on the intestinal function of the grass carps.

The invention provides application of gypenoside-XLIX to preparation of medicine for improving the liver fat metabolism. The medicine is used for preventing and / or treating relevant diseases caused byliver fat metabolism disorder. By building a cell model of non-alcoholic fatty liver diseases, the effect of the gypenoside-XLIX of obviously improving the liver fat metabolism is proved. Through experiments, the effects that the gypenoside-XLIX can be used for reducing the content of triglyceride in the liver cells, reducing the fat accumulation in the liver cells, and regulating down the SCD1 transcriptional level expression to relieve the liver fat metabolism disorder are discovered. Therefore, the gypenoside-XLIX has an important effect on the prevention and treatment of the non-alcoholicfatty liver diseases.

The invention discloses application of a traditional Chinese medicine composition in preparation of drugs for preventing and treating abnormal fat metabolism diseases. The traditional Chinese medicinecomposition is prepared from herba artemisiae scopariae, radix bupleuri, radix sophorae flavescentis, radix et rhizoma rhei and folium isatidis. Through screening of a large number of experiments, the traditional Chinese medicine composition provided by the invention has a good effect of reducing the content of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) of a hyperlipidemia animal model, and has a certain effect of increasing high-density lipoprotein cholesterol (HDL-C). The clinical experiments find that the Kuhuang granules can obviously improvebiochemical indexes and imaging evaluation results of fatty liver patients. In addition, the experimental result of the drug-induced liver injury shows that the traditional Chinese medicine composition provided by the invention can significantly improve the drug-induced liver injury and has the effect of preventing the liver injury.

The invention discloses a mixture of black fungi, royal jelly and giant salamander full powder and a preparation method thereof. The black fungi, the royal jelly and the giant salamander full powder in the mixture are nanometer fine powder, and the black fungi fine powder accounts for 10 to 30 percent, the royal jelly fine powder accounts for 10 to 30 percent and the giant salamander full powder accounts for 10 to 80 percent in percentage by weight. The preparation method comprises the following steps of: after being sterilized, the black fungi are ground into nanometer fine powder; after being processed by vacuum freeze drying, the royal jelly is ground into nanometer fine powder; after lungs and intestinal tract organs are removed, live giant salamander is processed by vacuum freezing, drying and pulverization and then ground into nanometer fine powder; and the thee kinds of powders are proportionally mixed to prepare the product. The mixture is rich in vitamin, protein, iron and other microelements as well as unsaturated fatty acid and amino acid, has comprehensive nutrition ingredients and reasonable proportion, meets the requirements of the food pyramid and is the nutrient health care product capable of reducing blood-fat and blood viscosity, reducing blood sugar in an auxiliary manner, balancing fat metabolism, glycometabolism, and the like and being convenient to take.

The invention relates to jelly containing soybean peptides and a preparation method of the jelly. The jelly is prepared from the following raw materials in percentage by weight: 2-8% of soybean peptides, 1-10% of jelly powder, 2-3% of pectin, 1-2% of carrageenin and the balance of water. The jelly has the physiological regulation effects of reducing blood fat, reducing cholesterol, reducing blood pressure, promoting absorption of mineral substances, promoting fat metabolism and the like.

The invention provides applications of a grapefruit extract in preparation of lipid-lowering functional food, healthy food or medicines. The grapefruit extract is prepared by the following steps: performing acetone ultrasonic extraction, rotary evaporation, solid-phase extraction column passing and vacuum drying to freeze-dried powder of extracts of a grapefruit oil gland layer, an albedo layer and a mesocarp layer. The body weight of high-lipid induced fat C57BL / 6 mouse can be reduced in vivo through the grapefruit extract, the masses of the liver and adipose tissues can be obviously decreased, the triglyceride, total cholesterol and low-density lipoprotein cholesterol containing in serum can be obviously reduced, and the triglyceride and total cholesterol contained in the liver can be reduced. The grapefruit extract can be used for prevention and treatment of fat metabolism abnormality related diseases as functional food, healthy products or preventive and treatment drugs.

The invention relates to the technical field of healthy food, and particularly discloses a compound anti-aging composition, a compound anti-aging tablet and a preparation method and application of the compound anti-aging composition and the compound anti-aging tablet. The compound anti-aging compositio is prepared from 100 to 200 parts of NMN, 2 to 3 parts of PQQ, 5 to 15 parts of quercetin, 200 to 400 parts of betaine and 300 to 400 parts of auxiliary materials, wherein the auxiliary materials comprise one or more of stevioside, calcium phosphate, magnesium stearate and silicon dioxide. According to the compound anti-aging compositio disclosed by the invention, the betaine is matched with the PQQ and the NMN, so that the cell osmotic pressure can be effectively regulated, the intestinal tract is protected, the stress reaction of the compound anti-aging compositio is reduced, and fat metabolism and protein synthesis of a human body are promoted; the effects of promoting energy metabolism of human cells and accelerating metabolism are also achieved while the immunity of the organism is enhanced; and the betaine can effectively reduce the probability that NMN, PQQ and quercetin are oxidized, so that the anti-oxidation, anti-inflammation and anti-aging effects of quercetin, PQQ and NMN on human cells after the quercetin, PQQ and NMN are compounded are further stimulated.

The invention provides application of a ring finger protein Rnf20 gene. By using a Cre-loxp system, an adipose tissue specific Rnf20 gene knockout mouse model is successfully prepared through mating of an Rnf20Flox / Flox mouse and an Adiponectin-Cre + mouse. Adipose specific Rnf20 gene knockout mice (Rnf20Fox / Fox; Adipectin-Cre +) and the control mice (Rnf20Flox / Flox) were used as experimental subjects to study the function of the Rnf20 gene in fat metabolism through animal models induced by age and high fat diet. The results show that compared with thecontrol mice, the adipose-specific Rnf20 gene knockout mice has lipid metabolism disorders that could mimic the pathogenesis of human lipodystrophy. The model is an ideal model for researching lipodystrophy, and has important application value.

The invention relates to a method for preparing peony pollen protein polypeptide by using peony pollen as a raw material, the peony pollen protein polypeptide prepared by the method, and the application of the protein polypeptide. The peony pollen protein polypeptide of the present invention is a peony pollen protein, or a peony pollen polypeptide. The dried peony pollen is used as a raw material, and the peony pollen protein is obtained through pollen wall breaking, crude protein extraction, and vacuum drying; the peony pollen protein is subjected to proteolysis, debittering, decolorization, centrifugation or filtration to obtain peony pollen polypeptide. The product can be in the form of powder, granule, tablet, capsule, oral liquid and the like. Peony protein polypeptide has the advantages of lowering cholesterol, lowering blood pressure, promoting fat metabolism, anti-fatigue, enhancing human immunity, regulating human physiological functions, etc. It has broad development and application prospects in the fields of food industry, health care and medicine.