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Composition for regulating sub-health status of crowd suffering from lipodystrophy

A fat metabolism and health status technology, applied in the field of biological preparations, can solve problems such as defects in leptin signal transduction pathways, reduce receptor proteins, and effector defects, so as to inhibit the synthesis of endogenous cholesterol in cells, promote absorption, The effect of reducing the content

Active Publication Date: 2015-05-27
SHENZHEN GENE BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

② Defects in hypothalamic leptin receptor signaling
For example, a high-fat diet can reduce the level of receptor protein, so that leptin cannot normally bind to its receptor, so that leptin cannot exert its effect on target tissues
③Leptin signal transduction pathway defect or effector defect
④ Leptin signal transduction pathway defect

Method used

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  • Composition for regulating sub-health status of crowd suffering from lipodystrophy
  • Composition for regulating sub-health status of crowd suffering from lipodystrophy
  • Composition for regulating sub-health status of crowd suffering from lipodystrophy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The total amount of raw materials is 100 kg. Among them, the materials of phase A are: 3 kg of glycerin, 3 kg of butanediol, 0.1 kg of sodium chloride, 5 kg of propylene glycol and deionized water; the materials of phase B are: 2 kg of isononyl isononanoate, polydimethylsiloxane 2 kg of oxane, 2 kg of hydrogenated polyisobutylene, 2 kg of dioctyl carbonate, 2 kg of octyl methicone, 2 kg of PEG-10 dimethicone, 2.5 kg of quaternary ammonium salt-90 bentonite , Ethylhexyl palmitate 2.4 kg, glycyrrhetinic acid 0.5 kg, stearyl inulin powder 0.3 kg; Phase C materials are: ginger (ZINGIBER OFFICINALE) extract 0.8 kg, carnitine 0.8 kg, Mexican yam (DIOSCOREA MEXICANA) Root extract 1.5 kg, COFFEA ARABICA seed extract 3.0 kg, Brazilian cocoa (PAULLINIA CUPANA) seed extract 3.0 kg, hydrolyzed red algae extract 1.5 kg, lotus (NELUMBO NUCIFERA) leaf extract 0.6 kg , Bitter orange (CITRUS AURANTIUM AMARA) flower extract 0.55 kg, cactus (OPUNTIA DILLENII) extract 0.45 kg, chamomile (...

Embodiment 2

[0057] The total amount of raw materials is 100 kg. Among them, the materials of phase A are: 2.0 kg of glycerin, 2.0 kg of butanediol, 0.05 kg of sodium chloride, 4.0 kg of propylene glycol and deionized water; the materials of phase B are: 2.95 kg of isononyl isononanoate, polydimethylsiloxane Oxane 2.3 kg, hydrogenated polyisobutylene 2.7 kg, dioctyl carbonate 2.6 kg, octyl methicone 3.4 kg, PEG-10 dimethicone 2.1 kg, quaternary ammonium salt-90 bentonite 3.9 kg , ethylhexyl palmitate 2.5 kg, glycyrrhetinic acid 0.4 kg, stearyl inulin powder 0.35 kg; phase C materials are: ginger (ZINGIBER OFFICINALE) extract 0.9 kg, carnitine 0.7 kg, Mexican yam (DIOSCOREA MEXICANA) Root extract 1.8 kg, COFFEA ARABICA seed extract 3.6 kg, Brazilian fragrant cocoa (PAULLINIA CUPANA) seed extract 3.5 kg, hydrolyzed red algae extract 1.4 kg, lotus (NELUMBO NUCIFERA) leaf extract 0.55 kg , Bitter orange (CITRUS AURANTIUM AMARA) flower extract 0.5 kg, cactus (OPUNTIA DILLENII) extract 0.5 kg, ...

Embodiment 3

[0066] The total amount of raw materials is 1000 kg. Among them, the materials of phase A are: 24 kg of glycerin, 23 kg of butanediol, 7.2 kg of sodium chloride, 46 kg of propylene glycol and deionized water; the materials of phase B are: 31 kg of isononyl isononanoate, polydimethylsiloxane Oxane 21 kg, hydrogenated polyisobutylene 22 kg, dioctyl carbonate 28 kg, octyl methicone 31 kg, PEG-10 dimethicone 27.2 kg, quaternary ammonium salt-90 bentonite 35.9 kg , Ethylhexyl palmitate 26.8 kg, glycyrrhetinic acid 5.1 kg, stearyl inulin powder 3.2 kg; Phase C materials are: ginger (ZINGIBER OFFICINALE) extract 8.7 kg, carnitine 6.4 kg, Mexican yam (DIOSCOREA MEXICANA) 16.9 kg root extract, 37.8 kg COFFEA ARABICA seed extract, 34.9 kg PAULLINIA CUPANA seed extract, 14.5 kg hydrolyzed red algae extract, 6.2 kg lotus (NELUMBO NUCIFERA) leaf extract , Bitter orange (CITRUS AURANTIUM AMARA) flower extract 6.3 kg, cactus (OPUNTIA DILLENII) extract 5.4 kg, chamomile (CHAMOMILLA RECUTITA)...

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Abstract

The invention discloses a composition for regulating the sub-health status of the crowd suffering from lipodystrophy. The composition mainly has the effects of reducing the expression of the hypothalamic neuropeptide gamma by influencing human leptin, improving the energy metabolism efficiency, increasing the energy consumption and inhibiting fat synthesis. The other components with fat decomposing effects are combined, so that the metabolism of human adipose tissues is promoted, and the intracellular oxidative phosphorylation effect and synthesis of cell endogenous cholesterol are inhibited. The composition can be used for achieving the effects of effectively infiltrating into the human skin, inhibiting the activity of lipase and reducing the synthesis of fat. By combining the traditional Chinese medicine naprapathy, the absorption and intracellular transport of the composition can be further promoted, the metabolism is promoted, the triglyceride in the fat is decomposed, the excretion of steroid and gallic acid is increased, the excretion of cholesterol and other metabolites can be accelerated, a local shaping effect is achieved, and the contents of glycerin and cholesterol in serum are reduced in an assisted mode. The pharmacological action of the cardiovascular system is improved, and the blood circulation is improved.

Description

technical field [0001] The invention relates to the field of biological preparations capable of regulating lipodystrophy, in particular to a composition for regulating the sub-health state of people with lipodystrophy and a preparation method thereof. Background technique [0002] In recent years, with the continuous improvement of material living standards, the proportion of people with autologous lipodystrophy has also been increasing, which makes people physically and psychologically burdened. Obesity is a sub-health state caused by the interaction of genetics and environment. Modern medical research shows that autologous lipodystrophy has become the root cause of various diseases in today's society, and it is easy to be complicated by hypertension, hyperlipidemia, hyperglycemia, cardiovascular disease, coronary heart disease, diabetes, stroke, fatty liver and other diseases. The health of the human body poses a serious threat, which makes the body in a sub-health state ...

Claims

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Application Information

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IPC IPC(8): A23L1/29A23L33/00
CPCA23V2002/00A23V2250/21A23V2250/54A23V2200/30A23V2200/326
Inventor 张泽奇韩敏杨平顺凌瑛刘芳
Owner SHENZHEN GENE BIOLOGICAL TECH
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