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Traditional Chinese medicine composition for treating abnormal fat metabolism diseases and application thereof

A fat metabolism abnormality and composition technology, applied in metabolic diseases, drug combinations, medical preparations containing active ingredients, etc., can solve problems restricting the clinical promotion and application of Kuhuang Granules, and improve biochemical indicators and imaging evaluation Result, good curative effect, effect of expanding clinical indications

Inactive Publication Date: 2020-04-07
雷允上药业集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no research report on the preparation of Kuhuang Granules in the treatment of abnormal fat metabolism, non-alcoholic fatty liver disease and drug-induced liver injury, which obviously restricts the clinical promotion and application of Kuhuang Granules

Method used

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  • Traditional Chinese medicine composition for treating abnormal fat metabolism diseases and application thereof
  • Traditional Chinese medicine composition for treating abnormal fat metabolism diseases and application thereof
  • Traditional Chinese medicine composition for treating abnormal fat metabolism diseases and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Observation of curative effect of Kuhuang granule on hypolipidemic effect of hyperlipidemia model rats.

[0021] 1 Materials and methods

[0022] 1.1 Experimental drug: Kuhuang Granules, produced by Leiyunshang Pharmaceutical Group Co., Ltd., approval number: Z20030141; Chinese medicine raw materials: 833.3 parts of Yinchen, 833.3 parts of Spring Bupleurum, 266.7 parts of Sophora flavescens, rhubarb 333.3 copies, 625 copies of Daqingye.

[0023] 1.2 Dosage: the recommended dose of the composition tablet of the present invention is adult (by 60kg body weight > 18g per day, which is equivalent to 0.3g / kg / d. Oral administration once a day, after continuous gavage for 28d, measure each index. Rat gavage volume is 0.5mL / 100g.Set up blank control group (0g / kg), model control group (0g / kg) simultaneously, replace test substance with sterile water, each time gavage volume and each test substance Groups are the same.

[0024] 1.3 Instruments and reagents

[0025] 1...

Embodiment 2

[0065] Embodiment 2 Improves the clinical observation of fatty liver and body weight

[0066] 1. Case selection, according to the non-alcoholic fatty liver diagnostic criteria in the guidelines for the diagnosis and treatment of alcoholic fatty liver disease formulated by the non-fatty liver and alcoholic liver disease group of the hepatology branch of the Chinese Medical Association in 2010

[0067] 1) No history of drinking or alcohol consumption equivalent to less than 140 grams / week (less than 70 grams / week for women);

[0068] 2) Obesity, diabetes, hyperlipidemia, etc. with risk factors;

[0069] 3) In addition to the clinical manifestations of the primary disease, there are non-specific symptoms and signs such as fatigue, indigestion, dull pain in the liver area, hepatosplenomegaly;

[0070] 4) Serum transaminase and glutamyl transpeptidase levels may increase from mild to moderate, with alanine aminotransferase as the main increase;

[0071] 5) Liver imaging findings ...

Embodiment 3

[0088] And through the liver imaging diagnosis after treatment, the features of fatty liver in 40 patients disappeared or were significantly alleviated, and the total effective rate of treatment was 85%. The test population has no obvious discomfort, indicating that the present invention has a good effect of improving fatty liver and reducing body weight. Example 3 Experimental Research on Resistance to Chemical Liver Injury

[0089] 1. Experimental materials and drugs

[0090] 1. Drugs and reagents

[0091] AST, ALT, MDA, SOD kits and Coomassie brilliant blue protein kits were purchased from Nanjing Jiancheng Bioengineering Institute; carbon tetrachloride (CCl 4 , analytically pure, Shanghai Lingfeng Chemical Reagent Co., Ltd.), use peanut oil to prepare 0.1% peanut oil solution; galactosaminoside (D-GalN, Sigma company), distilled water before use and diluted to 70mg / mL solution; Bifendate tablets (Jiangsu Pengyao Pharmaceutical Co., Ltd.), grind into fine powder and add ...

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Abstract

The invention discloses application of a traditional Chinese medicine composition in preparation of drugs for preventing and treating abnormal fat metabolism diseases. The traditional Chinese medicinecomposition is prepared from herba artemisiae scopariae, radix bupleuri, radix sophorae flavescentis, radix et rhizoma rhei and folium isatidis. Through screening of a large number of experiments, the traditional Chinese medicine composition provided by the invention has a good effect of reducing the content of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) of a hyperlipidemia animal model, and has a certain effect of increasing high-density lipoprotein cholesterol (HDL-C). The clinical experiments find that the Kuhuang granules can obviously improvebiochemical indexes and imaging evaluation results of fatty liver patients. In addition, the experimental result of the drug-induced liver injury shows that the traditional Chinese medicine composition provided by the invention can significantly improve the drug-induced liver injury and has the effect of preventing the liver injury.

Description

technical field [0001] The invention relates to a new application of Kuhuang Granules, in particular to the application of Kuhuang Granules in the preparation and treatment of non-alcoholic fatty liver disease and drug-induced liver injury, and belongs to the technical field of medicine. Background technique [0002] Abnormal fat metabolism refers to the abnormality of normal fat metabolism due to the comprehensive effect of many factors, which seriously affects health and life span, and will directly lead to various diseases, among which the most likely diseases are cardiovascular disease, fatty liver and obesity etc. [0003] Obesity is a chronic fat metabolism disease caused by many factors, characterized by an abnormally high percentage of body fat to body weight and excessive fat deposition in certain areas. According to the statistics of the World Health Organization, currently about 39% of adults in the world are overweight, and about 13% of them are obese. Obesity ...

Claims

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Application Information

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IPC IPC(8): A61K36/855A61K36/708A61P1/16A61P3/04
CPCA61K36/195A61K36/233A61K36/282A61K36/315A61K36/489A61K36/704A61K36/708A61K36/855A61K2236/331A61K2236/333A61P1/16A61P3/04A61K2300/00
Inventor 张丹丹王恒斌潘耀宗张邦国李全罗年翠戴晶晶翟云良
Owner 雷允上药业集团有限公司
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