57 results about "Diabetes mellitus type II" patented technology

The compositions and dosage forms of the invention are clinically useful as methods for increasing the effectiveness, efficiency and safety of biguanides (metformin) and/or sulfonylureas in the prevention and treatment of insulin resistance and diabetes mellitus, alone or in combination, as a nutrient for humans. The carefully chosen active ingredients of the invention are designed in a modular fashion to prevent and rectify adverse events associated with insulin resistance syndrome and diabetes mellitus, and with the clinical use of biguanides (metformin) and/or the sulfonylureas. These modules are: (1) Mitochondrial Metabolic Group, (2) Plasma and Mitochondrial Membrane Integrity Group, (3) Nocturnal Group and, (4) Insulin Alternative Group. When used in concert with a biguanide, a sulfonylurea or with a combination of both, the invention will broaden the clinical usefulness of these drugs. The invention will retard the progression of insulin resistance to type 2 diabetes, and reduce the serious microvascular and macrovascular complications commonly associated with insulin resistance syndrome and diabetes mellitus.

The invention relates to thiadiazole derivatives which are shown as a formula I and have DPP-IV (dipeptidyl peptidase IV) inhibition activity, a preparation method of the thiadiazole derivatives and drug compositions of the thiadiazole derivatives, and application of the thiadiazole derivatives to treatment of diseases beneficial from DPP-IV inhibition, especially application to treatment of diabetes mellitus type 2. The thiadiazole derivatives provided by the invention have very good DPP-IV inhibition activity, have a very good in-vivo metabolic level and a very proper in-vivo half-life period and are expected to be used as proper DPP-IV inhibitor drugs.

An active substance is extracted from an herbal composition which comprises: Centaurii umbellatum, Gentianaceae (centaury plant), Teraxacum officinale, Asteraceae (dandelion root), Juniperi communis L, Cupresaceae (juniper berry), Urticae dioica L, Urticeae (nettle plant), Urticae dioica L, Urticaceae (nettle root), Cichorium intybus L, Cichoriaceae (chicory root), Morus nigra L, Moraceae, (mulberry leaf), Achilleae millefolium L, Asteraceae (yarrow flower), Vaccinium myrtillus L, Ericaceae (bilberry leaf), Phaseolus vulgaris L, Fabaceae (bean pods), Valeriana officinalis L, Valerlanaceae (Valerian root). The active substance is used in the manufacture of pharmaceutical compositions used in connection with control of diabetes mellitus type II.

The invention relates to a novel sulfonamide compound in a structure of a general formula I as shown in the specification, or pharmaceutically acceptable salt and a preparation method of the novel sulfonamide compound, and further relates to a drug composition containing the compound as shown as the general formula I or the pharmaceutically acceptable salt of the compound, and a use of the compound or the pharmaceutically acceptable salt for preparing a drug for preventing and/or treating symptoms or diseases such as hyperglycemia and diabetes mellitus type 2 since the compound as shown as the general formula I or the pharmaceutically acceptable salt of the compound has activity of inhibiting a protein tyrosine phosphatase 1B (PTP 1B).

The invention relates to the field of medicine, in particular to a mirabilis jalapa root general flavone extractive for preventing and curing diabetes mellitus type 2 and a preparation method and application thereof. In the extractive, the content of general flavone is greater than 40%, when the dosage of the extractive is 100 mg/kg, the extractive has obvious effects on decreasing the content ofblood glucose, total cholesterol, triglycerides, tissue triglycerides and increasing glycogen content, prophylaxis and remedial medication have similar effects on blood glucose and lipid lowering of diabetes mellitus type 2 induced by streptozotocin, also reduce blood glucose and lipid type 2 diabetes (db/db) mice of gene knockout, and do not affect glucolipid metabolism of normal mice. Accordingto the preparation method of mirabilis jalapa root general flavone extractive, mirabilis jalapa root general flavone is separated and purified by macroporous adsorption resin, in the prepared mirabilis jalapa root general flavone extractive, the content of the general flavone is greater than 40 %, the transfer rate reaches up to 70 %, and the yield rate can reach up to 2 %.

The invention relates to a dietary supplement comprising alpha keto acids for supporting diabetes therapy. The invention relates to a preparation used as a dietary supplement comprising alpha keto acids for supporting therapy of diabetes mellitus type II (DM). The preparation comprises at least one of the alpha keto acids from the group alpha ketoisocaproate (KIC), alpha ketoisovalerate (KIV), alpha keto beta methylvalerate (KMV) and alpha keto glutarate (AKG).

Described are positive allosteric modulators of the GLP-1 receptor, pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for diabetes mellitus type 2, obesity, depression, Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, cognitive dysfunction, learning disability, and asthma in a subject.

The invention relates to a functional nutritional powder composition suitable for patients with diabetes mellitus type II. The functional nutritional powder composition is prepared from the following raw materials by weight percent: 20-50% of soybean protein, 1-10% of whey protein, 15-35% of skim milk powder, 8-30% of konjac flour, 10-40% of beer yeast, 5-30% of resistant maltodextrin and sucralose. The functional nutritional powder composition can provide high-quality and complete protein, complete B-vitamin group, fourteen life-bound high-quality minerals, trace elements and high-quality functional dietary fibers. The functional nutritional powder composition supplements the nutritional components needed by special groups, controls the intake of carbohydrate, increases satiety, balances dietary structure and reduces kidney burden; the functional nutritional powder composition has the effects of adjusting blood glucose as well as preventing and treating early and middle stage of diabetes mellitus type II by repairing pancreas islets function and insulin receptor binding ability.

The invention relates to corylin compositions for treating or preventing any one or more of hyperlipemia, hyperglycemia, nonalcoholic fatty liver and diabetes mellitus type 2; the compositions can be prepared into medicines, health foods or functional foods; excipients or carriers used for the compositions are excipients or carriers such as diluents, disintegrating agents and lubricating agents which are commonly used in the field of pharmacy or food.

The invention relates to combinations of (2R,4aR,10bR)-6-(2,6-Dimethoxy-pyridin-3-yl)-9-ethoxy-8-methoxy-1,2,3,4,4a,10b-hexahydrophenanthridine-2-ol with other active compounds for the treatment of diabetes mellitus type 2 and/or type 1.

The invention discloses chalcone derivatives containing allyl structures, and application of the chalcone derivatives. 39 novel allyl-progeny steranes, based on licochalcone A and E used as pre-molecules are synthesized. As a PTP1B inhibitor, the chalcone derivatives can improve the treatment of common diabetes mellitus type 2. Most synthetic compounds show potent inhibition on PTP1B.

Disclosed is a use of Helminthostachys zeylanica, ugonins or compounds of formula (I) for the treatment or prevention of metabolic diseases comprising at least one selected from metabolic syndrome, excessive lipid accumulation, obesity, overweight, fatty liver, hepatic steatosis, hepatitis, cirrhosis, liver cancer, dyslipidemia, hyperlipidemia, hypertriglyceridemia, hyperlipoproteinemia, hypercholesterolemia, cardiovascular disease, hyperglycemia, hyperinsulinemia, diabetes mellitus type 2, insulin resistance, insulin disorder, impaired glucose tolerance and a combination thereof.

The invention belongs to the technical field of traditional Chinese medicine and relates to qi supplementing and yin nourishing glycemic control pills for treating qi and yin deficiency of diabetes mellitus type 2 and a preparation method of the pills. The pills are prepared from a pulverization group and a decoction group in the following weight ratio: the pulverization group is prepared from thefollowing components in a weight ratio: 135-150 g of radix pseudostellariae, 120-140 g of common macrocarpium fruit, 45-65 g of fructus schisandrae, 120-140 g of raw rhizoma dioscoreae, 120-140 g oforiental waterplantain rhizome, 120-140 g of poria cocos, 40-70 g of radix ophiopogonis and 130-145 g of dry radix rehmanniae recens; the decoction group is prepared from the following components in aweight ratio: 190-210 g of raw radix astragali, 40-50 g of fried rhizoma atractylodis, 35-45 g of fried rhizoma atractylodis macrocephalae, 135-148 g of radix salviae miltiorrhizae, 50-80 g of friedfructus aurantii and 15-30 g of rhizoma cimicifugae pieces. The medicines are scientific and reasonable in compatibility, supplement one another and jointly have the effects of supplementing qi and nourishing yin when mixed for use, qi is restored and yin is coordinated, qi and yin are in harmony, and accordingly, glycemic control is realized. The preparation process of the drug is simple, the drug is convenient to apply and has remarkable effect and no side effect, and relapse is avoided.