32 results about "Sterane" patented technology

The invention provides a method utilizing C29 sterane isomerization parameters for representing oil-gas migration. The method includes: firstly, creating a base curve according to thermal evolution of source rocks and crude oil; secondly, subjecting oil samples to chromatography/mass spectrometry analytical test; thirdly, calculating the C29 sterane isomerization parameters of the oil samples, tracing oil-gas migration paths according to a mode utilizing the C29 sterane isomerization parameters for representing oil-gas migration, and predicting favorable oil-gas accumulation areas. The method utilizing the C29 sterane isomerization parameters for representing oil-gas migration has the advantages that by means of calculating the C29 sterane isomerization parameters of the crude oil in subsurface reservoirs and analyzing change trends of the subsurface reservoirs, an oil-gas migration process including migration paths, power conditions, migration distances and the like is traced effectively, so that oil-gas accumulation study can be detailed, and the method is of important significance to an oil-gas migration mechanism and distribution regularities.

The present invention relates to the new process of synthesizing furasteroid saponin and its derivative chemically with C27 helical sterane type sapogenin and various kinds of saccharide as material. The synthesis process includes the following steps: 1. synthesizing completely protected C27 helical steroid saponin through the reaction of C27 helical sterane type sapogenin and acyl radical, alkyl radical or silicon radical protected glycosyl donor; 2. reaction of completely protected helical steroid saponin and oxidant to obtain oxidized product; 3. reaction of oxidized helical steroid saponin and oxyphilic reagent to produce place 26 halogenated saponin derivative; 4. nucleophilic substitution reaction of nucleophilic reagent and the halogenated product to introduce XR3 radical; 5. reducing the place 16 carbonyl radical in saponin selectively with reductant; and 6. eliminating all the protecting radicals to obtain furasteroid saponin and its analog.

The invention discloses harmful mycogone perniciosa 88362 with the preservation number of CGMCC NO.8352. Ergot sterane type triterpenoid prepared by fermenting the harmful mycogone perniciosa has a structural formula shown in the specification. The invention provides a new strain, two new components and a method for preparing the new compounds by utilizing the new strain, and a material base is provided for developing and utilizing natural active substances from microorganisms.

The invention discloses an application of Lanosta-7,9(11),24-trien-3-one 15,26-dihydroxy in preparation of medicaments for preventing and/or treating enterovirus 71 infection. The invention confirms that the Lanosta-7,9(11),24-trien-3-one 15,26-dihydroxy has good antiviral effect in in-vitro enterovirus 71 (EV 71) infection cell tests. Meanwhile, the Lanosta-7,9(11),24-trien-3-one 15,26-dihydroxyhas certain killing effect on enterovirus 71 (EV 71), can prevent enterovirus 71 (EV 71) infection, has good treating effect on enterovirus 71 (EV 71) infected cells, has good inhibition effect on viral replication, and has more significant effect than a positive control medicament of ribavirin. In addition, the Lanosta-7,9(11),24-trien-3-one 15,26-dihydroxy has good inhibition effect on inflammation responses caused by enterovirus 71 (EV 71), which reveals that the Lanosta-7,9(11),24-trien-3-one 15,26-dihydroxy has the prospect of being developed into anti-enterovirus 71 (EV 71) medicaments.

The invention discloses an improved full-automatic solid-phase extraction instrument and application thereof to automatic separation of monoaromatic sterane. The automatic solid-phase extraction instrument comprises a solvent system, a solvent switching valve, a metering pump, a chromatographic column and a collecting system in sequence, wherein the systems are connected through a flow passage circuit; an appropriate solvent is selected by controlling the solvent switching valve to be pumped into the chromatographic column by the metering pump; all kinds of substances adhered onto a solid phase of the chromatographic column are separated; and the eluted different substances are controlled by mechanical arms of the collecting system to flow into different receiving flasks. According to a method for separating the monoaromatic sterane by the instrument, the monoaromatic sterane is completely separated from saturated hydrocarbon component and completely enters an aromatic hydrocarbon component. The method solves the problem that saturated hydrocarbon is mutually mixed with aromatic hydrocarbon in an existing method, complete separation of monoaromatic sterane substances is realized, and the improved full-automatic solid-phase extraction instrument is introduced, so that automation of sample analysis is realized, and the disadvantages of complex operation and low work efficiency for manual separation are greatly avoided.

The invention provides a method for determining migration dynamic conditions by utilizing hydrocarbon-type geochemical parameters of oil deposits. The method for determining migration dynamic conditions by utilizing hydrocarbon-type geochemical parameters of the oil deposits comprises the steps that 1, classified calibration of a hydrocarbon source rock stratum and biological marker feature analysis are performed; 2, oil deposit sample analysis and oil and source comparison are performed, and the oil deposits are classified according to oil sources; 3, the change laws with depths of hydrocarbon-type sterane isomerization parameters and light-heavy ratio parameters of same-type-source oil deposits or single-source oil deposits are established, and mode curves are drawn; 4, influence factorsof trend changes of trend lines are analyzed; 5, dynamic condition analysis and distinguishing are performed, and dynamic systems are divided. The method for determining migration dynamic conditionsby utilizing the hydrocarbon-type geochemical parameters of the oil deposits utilizes multiple geochemical parameters to determine a dynamic environment for hydrocarbon migration, research of an oil-gas reservoir forming mechanism is achieved, and evidences for migration and reservoir forming research are more directly and reliably provided.

The invention discloses chalcone derivatives containing allyl structures, and application of the chalcone derivatives. 39 novel allyl-progeny steranes, based on licochalcone A and E used as pre-molecules are synthesized. As a PTP1B inhibitor, the chalcone derivatives can improve the treatment of common diabetes mellitus type 2. Most synthetic compounds show potent inhibition on PTP1B.

The invention discloses a preparation method of a rocuronium bromide intermediate 5alpha-sterane-2-ene-17-one. The specific steps include: sequentially adding epiandrosterone TS, a solvent and a phasetransfer catalyst into a reaction bottle, performing heating to a reaction temperature of 90-120DEG C, carrying out stirring reaction, and conducting post-treatment purification to obtain the 5alpha-sterane-2-ene-17-one. The method provided by the invention greatly shortens the reaction time, reduces byproducts, enhances the yield, reduces three wastes, lowers the production cost, is suitable forindustrial production, and has obvious social and economic benefits.

The invention relates to a method for separating gonane and hopane from crude oil or rock extract, which comprises: passing 80 milligrams of crude oil or rock extract through 6 grams of silica gel-packed column with a particle diameter of 100 to 200 meshes, and leaching with 15 milliliters of n-hexane to obtain saturated hydrocarbons; volatilizing solvent on a nitrogen evaporator, weighing a saturated hydrocarbon, passing the saturated hydrocarbon through zeolite sieve of molecular porosity (ZSM) molecular sieve-packed column of which the mass is 100 times that of the saturated hydrocarbon, leaching with 20 milliliters of isooctane to obtain an isohydrocarbon; volatilizing solvent on a nitrogen evaporator, and weighing the saturated hydrocarbon; weighing 3.0 grams of NaY molecular sieve-packed column, and allowing 8.0 milligrams of isohydrocarbon to be absorbed on about 80 milligrams of coarse silica gel; transferring the isohydrocarbon onto the NaY molecular sieve column by using cold n-pentane and leaching with cold n-pentane; and collecting diffident required samples according to different amounts, namely collecting gonane first and then collecting hopane. The result of chromatography-mass spectrometry shows that the separation effect is desirable.

The present invention relates to a method for analyzing sterane-based compounds in a petroleum geological sample. According to the method, organic matters in a rock core sample are extracted with an organic solvent, and the extracted supernatant is directly analyzed through atmospheric pressure photoionization high resolution mass spectrometry (APPI FT-ICR MS). According to the present invention,with the method, the sample consumption is low, the sample preparation process is simple, the sample extraction time is short, and the extract can be directly subjected to atmospheric pressure photoionization high resolution mass spectrometry analysis without concentration and separation so as to avoid the compound loss caused during the separation; and the atmospheric pressure photoionization high resolution mass spectrometry analysis process is accurate and rapid, the sterane-based compound carbon number distribution range detected by the high resolution mass spectrometry has high reliability and high accuracy compared to the GC-MS results, and the method for analyzing the sterane-based compounds in the petroleum geological sample is expanded.