Triterpenoid composition of antrodia cinnamomea, preparation and analysis method thereof

A kind of composition and technology of triterpenoids, applied in the field of Antrodia camphorata fruit body composition, can solve the problems such as being unable to effectively separate the Antrodia camphorata fruit body composition and the like

Inactive Publication Date: 2012-08-01
KAOHSIUNG MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to overcome the problem that the existing technology cannot effectively separate the composition in the fruiting body (or mycelium) of Antrodia camphorata or the extract of Antrodia camphorata, and determine the three-dimensional structure of the composition, the present invention uses high performance liquid chromatography and nuclear magnetic resonance spectrum and other technologies to separate, purify, and analyze the ergostane (ergostane) and lanostane (lanostane) triterpenes in the fruiting body of Antrodia camphorata, as well as their three-dimensional structure and content

Method used

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  • Triterpenoid composition of antrodia cinnamomea, preparation and analysis method thereof
  • Triterpenoid composition of antrodia cinnamomea, preparation and analysis method thereof
  • Triterpenoid composition of antrodia cinnamomea, preparation and analysis method thereof

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Embodiment

[0037] In order to facilitate the description of the ergostane triterpenoid compositions E1 to E12 extracted by the present invention, the structural formulas (formulas I to X) corresponding to the compositions E1 to E12 and their high-performance liquid chromatograms are first described here. The peaks are detailed below.

[0038]

[0039]

[0040]

[0041] In order to facilitate the description of the lanostane triterpenoid compositions L1-L6 extracted by the present invention, the corresponding structural formulas (formulas XI to XVI) of the compounds L1-L6 and their corresponding peaks in the high-performance liquid chromatogram are listed as follows. .

[0042]

[0043]

[0044] Experiment 1. Preparation of ethyl acetate extract of Antrodia camphorata fruiting body

[0045] see figure 1 According to the preparation method 10, the dried Antrodia camphorata fruit body is ground into fine powder (step 12), and placed in an ethanol solution at 75° C. at a rat...

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Abstract

Disclosed are the isolation, purification and analysis of the triterpenoid compositions (including ergostane and lanostane) in the fruiting body of Antrodia cinnamomea using HPLC and NMR, as well as the stereo structures and the amounts of the triterpenoid compositions. The cytotoxicity of triterpenoids is also revealed. Based on the aforementioned techniques, the presence and amounts of ergostane and lanostane in the drugs, healthcare food or other goods are able to be detected.

Description

technical field [0001] The present application relates to an Antrodia camphorata fruiting body composition, and in particular, the present application relates to an Antrodia camphorata fruiting body triterpenoid composition, as well as a preparation method and an analysis method of the triterpenoid composition. Background technique [0002] Antrodia cinnamomea (Androdia cinnamomea), also known as Antrodia cinnamomea, Antrodia cinnamomea, Antrodia cinnamomea, etc., is a unique fungal species in Taiwan. It grows on the inner wall of the decayed heartwood of the trunk of the unique Cinnamomum kanehirai tree at an altitude of 400 to 2000 meters, or withered. The dark, damp surface of fallen cinnabar wood. Therefore, it is not easy to find the wild fruiting body of Antrodia camphorata or to confirm the appearance of this fungal strain of the order Aphyllophorales, and due to the potential medicinal value of its bioactive components, the price of Antrodia camphorata is high Not t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P35/00G01N24/08
CPCC07J9/00A61K31/592A61P35/00C07J9/005G01N24/08G01N30/02G01N33/50G01N2030/027G01N2333/375G01R33/46
Inventor 吴永昌张芳荣吕美津杜英齐吴东颖许育铭
Owner KAOHSIUNG MEDICAL UNIVERSITY
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