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Dietary supplement comprising alpha keto acids for supporting diabetes therapy

A food supplement, ketoacid technology, applied in the field of type II diabetes treatment, can solve problems such as apoptosis

Inactive Publication Date: 2012-05-09
EVONIK DEGUSSA GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this also leads to the formation of polyamines known to cause apoptosis (programmed cell death)

Method used

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  • Dietary supplement comprising alpha keto acids for supporting diabetes therapy
  • Dietary supplement comprising alpha keto acids for supporting diabetes therapy
  • Dietary supplement comprising alpha keto acids for supporting diabetes therapy

Examples

Experimental program
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Effect test

Embodiment Construction

[0054] Research methods :

[0055] To test the effect of the combination of a mixture of branched chain alpha keto acids (BCKA) and AKG and physical exercise on glucose and insulin metabolism, muscle synthesis, increase in muscle efficiency, nitrogen metabolism, and general health in the case of type 2 diabetic patients. Influence, we conducted the following human studies: Subjects:

[0056] Two groups of subjects were recruited, 15 in each group. These 30 subjects were evaluated according to the study plan's inclusion criteria and assigned on the basis of clinical and anthropometric data. These subjects were then randomized in a "double-blind" fashion (Table 1). For sex distribution, age, and height, there were no statistically significant differences between the two groups.

[0057] Table 1. Anthropometric data of recruited subjects

[0058]

[0059] exercise :

[0060] Physical activity is performed in two ways. One way is carried out in the Sport and Rehabilit...

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Abstract

The invention relates to a dietary supplement comprising alpha keto acids for supporting diabetes therapy. The invention relates to a preparation used as a dietary supplement comprising alpha keto acids for supporting therapy of diabetes mellitus type II (DM). The preparation comprises at least one of the alpha keto acids from the group alpha ketoisocaproate (KIC), alpha ketoisovalerate (KIV), alpha keto beta methylvalerate (KMV) and alpha keto glutarate (AKG).

Description

technical field [0001] The present invention relates to a preparation for use as a food supplement and comprising alpha-keto acids It is used to support the treatment of diabetes, especially type 2 diabetes. Background technique [0002] Some studies have confirmed that the incidence of type II DM can be reduced through physical exercise. Physical exercise is the best preventive measure for DM, and it is also one of the most important therapeutic opportunities for DM treatment. It has been demonstrated that physical exercise leads to an improvement in glucose metabolism and thus also in the clinical course. [0003] Physical exercise results in muscle adaptations in which many cellular processes take place, including muscle damage, muscle regeneration, muscle hypertrophy, and muscle fiber transformation. Energy and protein metabolism play an important role in these cellular processes. In this case, amino acids are important players. [0004] However, for diabetics, phy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61K31/194A23L1/30A23L33/15
CPCA23L1/30A23V2002/00A61K31/19A23D9/00A61K31/194A23L33/10A61P5/50A61P3/10A23V2200/316A23V2200/31A23V2250/02A23V2200/328A61K9/08
Inventor A·卡劳H·格布哈特H·温德哈布M·科腾哈恩Y·刘J·M·施泰内克
Owner EVONIK DEGUSSA GMBH
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