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Application of mogroside extract to preparation of alpha-glucosidase inhibitor

A technology of mogroside and glucosidase, which is applied in the direction of drug combination, medical preparations containing active ingredients, metabolic diseases, etc.

Inactive Publication Date: 2016-05-11
ZHEJIANG WANLI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no relevant report on the relevant research on the inhibitory effect of the crude extract of Luo Han Guo on α-glucosidase.

Method used

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  • Application of mogroside extract to preparation of alpha-glucosidase inhibitor
  • Application of mogroside extract to preparation of alpha-glucosidase inhibitor
  • Application of mogroside extract to preparation of alpha-glucosidase inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0022] Example: Inhibition of Mogroside Extract on α-Glucosidase

[0023] 1.1 Reagents and main instruments

[0024] 4-Nitro-α-D-glucopyranoside (CAS: 3767-28-0) and α-glucosidase (CAS: 9001-42-7) were purchased from Sigma, USA; acarbose was purchased from Bayer, Germany; other reagents were of domestic analytical grade. American Bio-tekSynergyTMHT super multifunctional microplate reader, American Biotek company; Swiss TecanInfinite200PRONanoQuant microplate reader, Swiss Tecan Group company.

[0025] 1.2 Experimental method

[0026] 1.2.1 Preparation of mogroside extract

[0027] (1) Select fresh Luo Han Guo fruits with a fruit age of 40-50 days, wash and remove hair, vacuum freeze-dry, pulverize with a pulverizer, pass through a 40-mesh sieve, and set aside.

[0028] (2) Take the pulverized Momordica grosvenori powder, add 70% ethanol according to the ratio of material to liquid of 1:40 (w / v), heat and reflux in a water bath at 80°C for 2 hours, filter to obtain the filt...

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Abstract

The invention discloses new application of mogroside extract, and particularly relates to application of mogroside extract to preparation of an alpha-glucosidase inhibitor. The research indicates that the mogroside extract has a certain inhibiting effect on alpha-glucosidase, the inhibiting effect on alpha-glucosidase is of a mixed type, and mogroside extract has a strong static quenching effect on alpha-glucosidase endogenous fluorescence. It is indicated that the mogroside extract can be applied to preparation of food, healthcare food and drugs for treatment or adjuvant treatment on diabetes mellitus type II.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the application of mogroside extracts in the preparation of alpha-glucosidase inhibitors. Background technique [0002] Diabetes mellitus is a syndrome characterized by persistent high blood sugar as its basic biochemical feature. It is mainly due to the disorder of glucose metabolism caused by the relative or absolute deficiency of insulin in the body. Diabetic patients can develop various complications in the state of long-term hyperglycemia. The mechanisms of various hypoglycemic substances reported today are different, and they are often multi-target, multi-effect, and multi-pathway comprehensive effects. Inhibition of the activity of a-glucosidase delays the digestion time of overall carbohydrates and reduces Postprandial hyperglycemia, prevention and treatment of diabetes and reduction of diabetic complications are considered to be an ide...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P3/10
CPCA61K31/704A61K2300/00
Inventor 戚向阳刘合生喻柯柯曹少谦杨华
Owner ZHEJIANG WANLI UNIV
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