The invention relates to crocodile bone meal and a preparation method thereof. The crocodile bone meal comprises crocodile bone powder, crystal sugar, yellow wine and crocodile colla corii asini, wherein the weight ratio of the crocodile bone powder to the crystal sugar, to the yellow wine and to the crocodile colla corii asini is (800-1200) to (20-40) to (4-6) to (1-3). The crocodile bone meal disclosed by the invention has the effects of strengthening the muscles and bones, replenishing essence, benefitting marrow and promoting blood circulation, can promote blood circulation, has good treatment effects on rheumatic osteodynia and rheumatoid arthritis, can have the effects of treating both manifestation and root causes of diseases, and can also prevent and treat senile osteoporosis, pediatric cartilage disease and the like; besides, the yellow wine is added, so that absorption can be facilitated, and nutrient substances of active calcium, phosphorus, bone glue and the like in the crocodile bone meal quickly enter human bodies; the crystal sugar is added, so that the problem that people suffer from excessive internal heat caused by eating the crocodile bone meal for a long term can be solved; and besides, the crocodile bone powder and the crocodile colla corii asini are organically combined, so that the effects and the efficacies of the crocodile bone powder and the effects and the efficacies of the crocodile colla corii asini can be well exerted.