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Compound betamethasone suspension injection

A kind of betamethasone dipropionate, injection technology

Inactive Publication Date: 2008-04-30
TIANJIN HANKANG PHARMA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, diseases such as allergic asthma, urticaria, hypertrophic lichen planus, keloids, and osteoarthritis have seriously endangered the health of the general public, and at the same time caused a heavy burden to families and society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Embodiment 1: the preparation of compound betamethasone injection

[0095] Preparation: ampoules, processed according to conventional methods. Betamethasone dipropionate is ultrafinely pulverized so that its particle size is less than 15 μm.

[0096] 1. Preparation of suspension

[0097] (1) Take 60% of the prescribed amount of water for injection (temperature: 75-85° C.), add the prescribed amount of sodium carboxymethyl cellulose, stir and dissolve, put it in a refrigerator at 0-10° C. to cool, and then take it out; Dissolve polysorbate 80 and polyethylene glycol 400 with an appropriate amount of water for injection (80-90°C) and add; then add ultrafinely pulverized betamethasone dipropionate and stir thoroughly, and then use a 300-350 mesh filter to , and filtered to obtain solution (A).

[0098] (2) Take 30% of the prescribed amount of water for injection (temperature: 80-90°C), add methyl p-hydroxybenzoate and propyl p-hydroxybenzoate and stir well to dissolve i...

Embodiment 2

[0101] Embodiment 2: the composition of compound betamethasone injection

[0102] Betamethasone dipropionate (calculated as betamethasone) micronized

[0103] Betamethasone sodium phosphate (calculated as betamethasone)

[0104] Add water for injection to 1000ml

Embodiment 3

[0105] Embodiment 3: the composition of compound betamethasone injection

[0106] Betamethasone dipropionate (calculated as betamethasone) micronized

[0107] Add water for injection to 1000ml

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PUM

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Abstract

The invention provides a compound betamethasone suspension injection, which is a compound preparation composed of low-solubility betamethasone dipropionate and high-solubility betamethasone sodium phosphate. Long-lasting, it can be used for the treatment of musculoskeletal and cartilage tissue diseases, allergic diseases, skin diseases, collagen diseases, tumors and other clinical diseases.

Description

technical field [0001] The invention relates to pharmaceutical preparations, in particular to a compound betamethasone suspension injection. The injection is composed of low solubility betamethasone dipropionate and high solubility betamethasone sodium phosphate. Background technique [0002] Allergic diseases and allergic diseases are common and frequently-occurring diseases in clinic. It can affect various internal organs of the human body, such as joints, skin, kidneys, respiratory tract, and digestive tract. Mild cases such as allergic rhinitis are only transient symptoms such as nasal congestion and sneezing; severe cases such as allergic asthma and lupus nephritis can be life-threatening. At present, with the continuous update and development of antibiotics and antiviral drugs, bacterial diseases and viral diseases have been well controlled, while allergic diseases and allergic diseases have become the main killers that threaten human health. According to statistics...

Claims

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Application Information

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IPC IPC(8): A61K31/573A61K9/10A61K47/38G01N30/02A61P37/08
Inventor 严洁
Owner TIANJIN HANKANG PHARMA BIOTECH
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