40 results about "Breast cancer chemotherapy" patented technology

The invention provides an application of miR-218 in preparing a breast cancer chemotherapeutic drug sensitizer, and belongs to the technical field of molecular drugs of breast cancer. According to theapplication of miR-218 in preparing the breast cancer chemotherapeutic drug sensitizer, miR-218 can obviously increase the sensitivity of breast cancer cells to paclitaxel and doxorubicin; in addition, miR218 can target down-regulate the expression of a DAAM1 gene, and inhibit the proliferation and invasion capacity of breast cancer cells by target down-regulating the expression of the DAAM1 gene. Therefore, a nucleic acid sequence is used as a novel small nucleic acid anti-tumor medicament, so that the sensitivity of breast cancer to chemotherapy medicaments can be enhanced, the proliferation and invasion of tumors can be inhibited, and the nucleic acid sequence has a good application prospect.

The invention discloses an acupoint patch capable of strengthening the spleen and stomach and a preparation method of the acupoint patch and relates to the technical field of traditional Chinese medicine patches. The acupoint patch is prepared from traditional Chinese medicines including fructus perillae, fructus evodiae, rhizoma pinelliae, pericarpium citri reticulatae, fructus schisandrae, caulis polygoni multiflori and semen ziziphi spinosae. The preparation method of the acupoint patch comprises the following steps: (1) weighing all the raw materials in parts by weight; (2) grinding the fructus perillae, the fructus evodiae, the rhizoma pinelliae, the pericarpium citri reticulatae, the fructus schisandrae, the caulis polygoni multiflori and the semen ziziphi spinosae into powder; (3) squeezing fresh ginger to obtain fresh ginger juice; (4) uniformly stirring the powder in step (2) with the fresh ginger juice in step (3) and water according to the weight proportion of 100 to (1 to 10) to (30 to 50); uniformly coating stirred medicine paste in a medical patch groove to obtain the acupoint patch. The acupoint patch disclosed by the invention has simple components, but also has a remarkable medicinal effect; effective components can be completely absorbed through skin pores and the acceptability of patients is strong. When the application time is long, no allergic phenomenon occurs and medicines remained on skins are easy to wash; the attachment property is strong. The acupoint patch disclosed by the invention is used for treating gastrointestinal reaction caused by breastcancer chemotherapy; the immunity is improved, the clinical effect is remarkable and the acupoint patch is worthy of being affirmed.

The invention relates to a medicine delivery system for combined precise treatment of breast cancer and application thereof. Ferroferric oxide is used as a magnetic ligand; meso-porous silicon-graphene nano-sheets are used as basic carriers; medicine delivery carriers are obtained through hydrophilic polymers of polyethylene glycol; the medicine delivery carriers and an insoluble micromolecular chemotherapeutic medicine of adriamycin form a meso-porous silicon-graphene nano-sheet-ferroferric oxide-polyethylene glycol / adriamycin medicine delivery system. The system can be used for the combinedprecise treatment (combining chemotherapy and photothermal therapy) of the breast cancer; the death rate of the breast cancer cells can be obviously improved. Compared with the medicine delivery system built by the prior art, the medicine delivery system has the advantages that various advantages are integrated; the combined targeted treatment of the breast cancer chemotherapy and photothermal therapy can be realized; the toxic and side effects of the whole body can be reduced; the repeated and complicated medicine delivery can be avoided through good medicine release features; the complianceof patients is improved.

The invention relates to a chemotherapy composition, a preparation method thereof and breast cancer chemotherapy application thereof. The composition is characterized in that the toxicity is small, the anti-cancer activity is high, the composition is mainly composed of a ginsenoside component, a ginseng polysugar component and ifosfamide according to a certain ratio, and the weight ratio is (1-10):(1-10):(1-10). Compared with ifosfamide, the composition has higher anti-cancer activity on experimental breast cancer mice and is almost free of adverse reactions such as myelosuppression.

The invention relates to a marker and a model for predicting chemotherapy response of triple negative breast cancer. The marker comprises one or a combination of more than two of the following genes: AKT2, ARG1, BIRC7, CCR3, CDKN2A, CHGB, CNN1, CYP7A1, FGF5, KMT2A, NME1, NRAS, PCP4, PRC1, PRKCI, SUZ12, VEGFC, WRN and ZBTB16. According to the method, the chemotherapy response is taken as a target function, and the accurate model for predicting the chemotherapy response of the triple-negative breast cancer is established by utilizing the whole transcriptome data of the triple-negative breast cancer slice based on an iterative linear regression algorithm of correlation coefficient layering. By utilizing the model, evaluation can be performed before chemotherapy of a triple-negative breast cancer patient, and the model is used for guiding establishment of a treatment scheme.