Chemotherapy composition, preparation method thereof and breast cancer-resistant application thereof

A composition and breast cancer technology, applied in drug combinations, antineoplastic drugs, pharmaceutical formulations, etc., can solve problems such as adverse reactions, affecting the quality of life of breast cancer patients, and limiting cancer treatment

Active Publication Date: 2016-02-03
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ifosfamide, like all chemotherapeutic drugs, can effectively inhibit cancer cells, but also has serious adverse reactions, such as bone marrow suppression, which seriously affects the quality of life of breast cancer patients and limits the survival of cancer. further treatment

Method used

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  • Chemotherapy composition, preparation method thereof and breast cancer-resistant application thereof
  • Chemotherapy composition, preparation method thereof and breast cancer-resistant application thereof
  • Chemotherapy composition, preparation method thereof and breast cancer-resistant application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Example 1: Accurately weigh 8 g of ginsenosides, 5 g of ginseng polysaccharides and 5 g of ifosfamide, and mix them uniformly to obtain the compound composition 1. Among them, ginsenoside Re accounts for about 2.2% of composition 1, ginsenoside Rg1 accounts for about 2.6% of composition 1, ginsenoside Rb1 accounts for about 1.8% of composition 1, and galacturonic acid accounts for about 3.4% of composition 1. , arabinose accounts for about 4.1% of composition 1, mannose accounts for about 1.0% of composition 1, galactose accounts for about 2.7% of composition 1, glucose accounts for about 10.3% of composition 1, and rhamnose accounts for about 0.7% of composition 1, and fucose accounts for about 2.1% of composition 1.

Embodiment 2

[0067] Example 2: Accurately weigh 5 g of ginsenosides, 8 g of ginseng polysaccharides and 5 g of ifosfamide, and mix them to obtain the compound composition 2. Among them, ginsenoside Re accounts for about 1.4% of composition 2, ginsenoside Rg1 accounts for about 1.4% of composition 2, ginsenoside Rb1 accounts for about 1.1% of composition 2, and galacturonic acid accounts for about 5.5% of composition 2 , arabinose accounts for about 6.6% of composition 2, mannose accounts for about 1.6% of composition 2, galactose accounts for about 4.4% of composition 2, glucose accounts for about 16.5% of composition 2, and rhamnose accounts for about 1.1% of composition 2, and fucose accounts for about 3.3% of composition 2.

Embodiment 3

[0068] Example 3: Accurately weigh 4 g of ginsenosides, 9 g of ginseng polysaccharides and 5 g of ifosfamide, and mix them uniformly to obtain the compound composition 3. Among them, ginsenoside Re accounts for about 1.1% of composition 3, ginsenoside Rg1 accounts for about 1.3% of composition 3, ginsenoside Rb1 accounts for about 0.9% of composition 3, and galacturonic acid accounts for about 6.2% of composition 3 , arabinose accounts for about 7.4% of composition 3, mannose accounts for about 1.8% of composition 3, galactose accounts for about 4.9% of composition 3, glucose accounts for about 18.5% of composition 3, and rhamnose accounts for about 1.2% of composition 3, and fucose accounts for about 3.7% of composition 3.

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Abstract

The invention relates to a chemotherapy composition, a preparation method thereof and breast cancer chemotherapy application thereof. The composition is characterized in that the toxicity is small, the anti-cancer activity is high, the composition is mainly composed of a ginsenoside component, a ginseng polysugar component and ifosfamide according to a certain ratio, and the weight ratio is (1-10):(1-10):(1-10). Compared with ifosfamide, the composition has higher anti-cancer activity on experimental breast cancer mice and is almost free of adverse reactions such as myelosuppression.

Description

technical field [0001] The invention relates to a chemotherapy composition, its preparation method and its application in the treatment of breast cancer. Background technique [0002] Breast cancer is the second most common malignant cancer among women in my country. In recent years, with the influence of life pressure, irregular diet and various environmental factors, the incidence and mortality of breast cancer have shown an upward trend, seriously threatening women. Especially the health of women near menopause. Chemotherapy is one of the most important means of treatment for patients with advanced breast cancer. Its main mechanism is to kill cancer cells through chemical drugs to achieve the purpose of treating cancer. At present, long-term low-dose ifosfamide is often used clinically to treat patients with advanced breast cancer. This chemotherapy drug has the advantages of low price and high anti-cancer efficacy. However, ifosfamide, like all chemotherapeutic drugs, c...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P35/00A61K31/715A61K31/675
Inventor 李松林朱贺
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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