Traditional Chinese medicine syndrome differentiation type discrimination model and system in breast cancer chemotherapy period and construction method of traditional Chinese medicine syndrome differentiation type discrimination model

A technology for discriminating models and building methods, applied in medical informatics, medical automated diagnosis, computer-aided medical procedures, etc., can solve problems that cannot be completed by one person's experience, and achieve the effect of avoiding subjective errors

Pending Publication Date: 2022-03-11
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

Clinical experience is a valuable resource for learning TCM, but the standardized research on TCM syndrome differentiation cannot be completed by one person’s experience. More perfect type research, in order to give full play to the advantages of traditional Chinese medicine
However, there is no relevant statistics-based technology for the establishment of TCM syndrome differentiation and identification models during chemotherapy for breast cancer.

Method used

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  • Traditional Chinese medicine syndrome differentiation type discrimination model and system in breast cancer chemotherapy period and construction method of traditional Chinese medicine syndrome differentiation type discrimination model
  • Traditional Chinese medicine syndrome differentiation type discrimination model and system in breast cancer chemotherapy period and construction method of traditional Chinese medicine syndrome differentiation type discrimination model
  • Traditional Chinese medicine syndrome differentiation type discrimination model and system in breast cancer chemotherapy period and construction method of traditional Chinese medicine syndrome differentiation type discrimination model

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Example 1 Collection and entry of TCM syndrome information for breast cancer chemotherapy patients

[0081]1) Source of cases: Collected from December 2019 to January 2021, a total of 500 patients with malignant breast tumors treated with chemotherapy at Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of Traditional Chinese Medicine and Cancer Hospital Affiliated to Shanghai Fudan University , 400 cases are used as a test set for model building; 100 cases are used as a validation set for model validation.

[0082] 2) Diagnostic criteria: refer to "Surgery" (editor-in-chief: Chen Xiaoping, Beijing: People's Health Publishing House, 2nd edition in August 2010). Combined with the patient's clinical manifestations, physical examination, imaging examination, and pathological examination, it was diagnosed as breast cancer.

[0083] 3) Inclusion criteria: ① female; ② breast cancer patients with clear pathological diagn...

Embodiment 2

[0086] Example 2 Establishment of TCM Syndrome Type Discrimination Model during Breast Cancer Chemotherapy

[0087] 1) SPSS 21.0 software was used to statistically analyze the data in the TCM syndrome database during chemotherapy for breast cancer. According to the four syndrome types of liver depression and yin deficiency, qi and yin deficiency, spleen deficiency and blood deficiency, and qi stagnation and blood stasis, TCM syndrome differentiation is carried out. The original weight coefficient corresponding to each syndrome item in the relationship between syndrome differentiation and typing during chemotherapy of breast cancer (see Table 1-4) is used as the score ratio. Table 1-4 is the logistic regression analysis results of clustering into four categories (reserving syndrome items with original weight coefficient >0), where B represents the regression coefficient, and p represents the probability.

[0088] Table 1. Logistic regression analysis results of liver depressio...

Embodiment 3

[0120] Example 3 Verification of TCM Syndrome Type Discrimination Model during Chemotherapy for Breast Cancer

[0121] The 100 patients in the verification set included in Example 1 were compared with the degree of agreement between the TCM syndrome types determined by the TCM syndrome differentiation model established in Example 2 and the TCM syndrome types determined by experts. Taking the results of expert syndrome differentiation as the gold standard, calculate the sensitivity, specificity and accuracy of the TCM syndrome differentiation model for breast cancer chemotherapy period established in Example 2 relative to expert syndrome differentiation. The results are as follows: ①Syndrome of liver depression and yin deficiency: sensitive Degree: 0.70, Specificity: 0.91, Accuracy: 0.87, Youden Index: 0.66; ② Qi and Yin Deficiency Syndrome: Sensitivity: 0.65, Specificity: 0.95, Accuracy: 0.84, Youden Index: 0.86; ③ Spleen Deficiency Blood deficiency syndrome: sensitivity: 0.96...

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Abstract

The invention discloses a breast cancer chemotherapy period traditional Chinese medicine syndrome differentiation and typing discrimination model, which comprises four syndrome types of liver depression and yin deficiency syndrome, qi and yin deficiency syndrome, spleen deficiency and hemophthisis syndrome and qi stagnation and blood stasis syndrome, and discrimination threshold values. The discrimination threshold values of the four syndrome types are all 22.5. The invention further relates to a system for constructing the traditional Chinese medicine syndrome differentiation type discrimination model in the breast cancer chemotherapy period and a model construction method. According to the invention, traditional Chinese medicine is combined with statistics and big data, the traditional Chinese medicine syndrome differentiation and typing discrimination model in the breast cancer chemotherapy period is constructed, and a model construction method is established. According to the model constructed by the invention, traditional Chinese medicine application of breast cancer chemotherapy is normalized and standardized, and a new mode is provided for research, application and popularization of syndrome differentiation of traditional Chinese medicine.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine syndrome differentiation model, system and construction method for breast cancer chemotherapy. Background technique [0002] Breast cancer is a common malignant tumor in women. According to the statistics of the Global Cancer Database in 2018, there were 2.08 million new cases worldwide. The application of traditional Chinese medicine is the characteristic and advantage of breast cancer prevention and treatment research in my country. A large number of literature reports have confirmed that Chinese medicine intervention can effectively improve the immune status of breast cancer patients, improve the quality of life, reduce the recurrence and metastasis rate, and prolong the disease-free survival period. Syndrome differentiation and treatment is the core of TCM treatment, and objective and rational stage differentiation is hel...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/20G16H10/60G16H20/40
CPCG16H50/20G16H10/60G16H20/40
Inventor 江科李春阳盛佳钰董梦婷帕提古丽·加帕尔李晓菲袁敏佳
Owner YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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