A traditional Chinese medicine composition for chemosensitization of breast cancer and its preparation method

A breast cancer and composition technology, applied in the field of traditional Chinese medicine compositions and preparations for breast cancer chemotherapy sensitization, can solve the problems that do not meet the modernization and internationalization of traditional Chinese medicine, the medicinal substances and curative effects are not clear, and the quality control indicators are not strict. and other problems, to achieve the effect of inhibiting the growth of tumor cells, conducive to prevention and treatment, and small side effects

Active Publication Date: 2021-12-07
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the active substances and curative effects of the current anti-tumor traditional Chinese medicine are not yet clear, and the quality control indicators are not strict, so that the use of traditional Chinese medicine in treatment is greatly restricted, and it does not meet the requirements of modernization and internationalization of traditional Chinese medicine.

Method used

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  • A traditional Chinese medicine composition for chemosensitization of breast cancer and its preparation method
  • A traditional Chinese medicine composition for chemosensitization of breast cancer and its preparation method
  • A traditional Chinese medicine composition for chemosensitization of breast cancer and its preparation method

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preparation example Construction

[0054] (2) Preparation and determination of the test solution, place 0.1g of the Chinese medicine composition weighed in a 100mL conical flask, accurately add 20mL of methanol, ultrasonically extract for 60min, let it stand to cool, methanol makes up for weight loss, and take the supernatant An appropriate amount was passed through a 0.22 μm filter membrane to prepare the test solution, and 10 μL of the test solution was injected into the chromatographic system for determination.

[0055] (3) Preparation and determination of the reference substance solution, dissolve p-coumaric acid, calycosin glucoside, liquiritin, glycyrrhizic acid and curcumol reference substance with methanol to be the reference substance stock solution of appropriate concentration, then dilute with methanol respectively For different concentration gradients, pass through a 0.22 μm filter membrane to prepare a reference solution, inject 10 μL of the reference solution into the chromatographic system for mea...

Embodiment 1

[0067] Embodiment 1 decoction

[0068] Prescription: 15g decoction pieces of Hedyotis diffusa, 15g decoction pieces of Zezhu, 15g decoction pieces of Astragalus membranaceus, 15g decoction pieces of licorice.

[0069] Preparation method: Weigh each decoction piece, add 1200-1800mL of water, soak for half an hour, decoct for 1 hour, filter, continue decocting the dregs for 2 times, mix the filtered medicinal liquid from 3 times of decoction, decoct and concentrate to 1000mL.

[0070] Usage and dosage: Drink 1000mL (equivalent to 60g of the original medicine) daily, three times a day.

Embodiment 2

[0071] Embodiment 2 Granules

[0072] Prescription: 30g decoction pieces of Hedyotis diffusa, 30g decoction pieces of Zezhu, 30g decoction pieces of Astragalus membranaceus, 30g decoction pieces of licorice.

[0073]Preparation method: Weigh each raw material, pulverize, pass through No. 1 sieve, use 12 times, 10 times and 8 times the amount of 95% ethanol to reflux extract three times, each time for 1 hour, filter, the filtrate stands still, and take the supernatant , combined the supernatants extracted three times, concentrated under reduced pressure to form a paste, evaporated ethanol to obtain the raw material extract of the Chinese medicine compound preparation, added suitable excipients, flavoring agents and other common excipients to make granules, and took it as a single dose Divide into granules to obtain granules.

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Abstract

The invention discloses a traditional Chinese medicine composition for inhibiting the growth of breast cancer and enhancing its chemosensitivity, which is prepared from raw materials in the following proportions by weight: 1-10 parts of Hedyotis diffusa, 1-10 parts of Curcuma, Radix Astragali 1-10 parts, 1-10 parts of licorice, and a preparation method of a traditional Chinese medicine preparation for chemotherapy sensitization of breast cancer is also disclosed. The traditional Chinese medicine composition of the present invention has been shown by pharmacodynamic experiments and toxicological experiments that it can inhibit the growth of breast cancer, and is suitable for inhibiting the growth of paclitaxel-resistant breast cancer cells. It is safe and reliable, has few side effects, and is used in conjunction with chemotherapy drugs. It can increase the sensitivity of breast cancer cells to chemotherapy drugs, promote the apoptosis of breast cancer cells, and benefit the prevention and treatment of breast cancer.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound preparation, in particular to a traditional Chinese medicine composition for breast cancer chemosensitization and a preparation method, belonging to the field of medicine. Background technique [0002] Malignant tumors—cancer has become one of the major diseases that are common and seriously threaten human life and quality of life. According to the report of the World Health Organization in 1997, in 1996, among the 5.8 billion people in the world, about 6.3 million people died of cancer, accounting for about 12% of the total number of deaths, of which nearly 60% died of lung cancer, gastric cancer, breast cancer, colorectal cancer, Oral cancer, liver cancer, cervical cancer and esophageal cancer, malignant tumors are the second leading cause of death after cardiovascular diseases. Since 1996, more than 10.3 million cancer patients have been newly diagnosed every year in the world. By the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61P35/00
CPCA61K36/481A61K36/484A61K36/748A61K36/9066A61P35/00A61K2300/00
Inventor 王志宇王能向松涛杨博文王胜奇郑轶枫周建甫
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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