Application of IL-6R inhibitor and IL-4R inhibitor combined drug in breast cancer chemotherapy drugs

A technology of IL-4R and chemotherapy drugs, applied in the field of chemotherapy drugs, to achieve the effect of enhancing sensitivity

Pending Publication Date: 2020-12-04
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The present invention provides the application of IL-6R inhibitor and IL-4R inhibitor combined drug in breast cancer chemotherapeutic drugs, and solves the technical problems in the prior art such as non-specific treatment drugs against IL-6

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  • Application of IL-6R inhibitor and IL-4R inhibitor combined drug in breast cancer chemotherapy drugs
  • Application of IL-6R inhibitor and IL-4R inhibitor combined drug in breast cancer chemotherapy drugs
  • Application of IL-6R inhibitor and IL-4R inhibitor combined drug in breast cancer chemotherapy drugs

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Embodiment 1

[0051] Application of IL-6R inhibitor and IL-4R inhibitor combined drug in breast cancer chemotherapeutic drug, said breast cancer chemotherapeutic drug is cisplatin.

[0052] IL-6R inhibitors are interleukin-6 (IL-6) receptor inhibitors, IL-4R inhibitors are interleukin-4 (IL-4) receptor inhibitors, and IL-4 is involved in promoting the M2 pole of macrophages. IL-6 is a pleiotropic cytokine with a wide range of functions. Both of them are involved in the regulation of the growth and differentiation of various cells. In the tumor microenvironment, IL-4 and IL-6 are involved in promoting the polarization of macrophages. In the late stage of tumor development, the two cooperate to promote the polarization of macrophage M2 and have anti-inflammatory effects.

[0053] The application of the polypeptide analogs in the treatment of breast cancer drugs, the steps are:

[0054] The first step is to establish an in vitro co-culture system of breast cancer cells and macrophages to simu...

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Abstract

The invention discloses application of an IL-6R inhibitor and IL-4R inhibitor combined drug in breast cancer chemotherapy drugs. IL-4 participates in promoting macrophage M2 polarization, IL-6 is a multi-effect cell factor with wide functions, and IL-4 and IL-6 participate in regulating growth and differentiation of various cells, have the functions of regulating immune response, acute phase reaction and hematopoiesis and play an important role in anti-infection immune response of the body. In the tumor microenvironment, IL-4 and IL-6 participate in promoting macrophage polarization, IL-4 andIL-6 synergistically act in the later stage of tumor development to promote macrophage M2 polarization, and IL-4 and IL-6 have an anti-inflammatory effect and can promote tumor development. The effectof the IL-6R inhibitor and IL-4R inhibitor combined drug in the breast cancer chemotherapy drugs is researched through the synergistic effect of the IL-6R inhibitor and IL-4R inhibitor.

Description

technical field [0001] The invention relates to the technical field of chemotherapeutic drugs, in particular to the application of IL-6R inhibitors and IL-4R inhibitors in breast cancer chemotherapy drugs. Background technique [0002] The immune system is a major player in crosstalk in the tumor microenvironment. Tumor-associated macrophages (TAMs), accounting for 50% of the total tumor mass, are the major population of immune cells that constitute the tumor microenvironment, with properties designed to promote tumor growth and angiogenesis, tissue remodeling and suppress adaptive immunity. Macrophages have high plasticity to various external signals and participate in innate and adoptive immune responses. Depending on the microenvironmental signals present, macrophages are polarized into two distinct phenotypes, classically activated (M1) or alternatively activated (M2) macrophages. Tumor-associated macrophages (TAMs) closely resemble polarized M2s. Clinicopathological ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K33/243A61P15/14A61P35/00A61P29/00
CPCA61K45/06A61K33/243A61P15/14A61P35/00A61P29/00A61K2300/00
Inventor 周佳敏王国华叶莉莎高纯一吴昊鲍海妮耿劲松
Owner NANTONG UNIVERSITY
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