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Medical polyvinyl alcohol sponge and preparation method

A polyvinyl alcohol and sponge technology, which is used in medical science, bandages, absorbent pads, etc., can solve the problems of large cell diameter of sponge products, multi-inorganic strong acid catalysts, and large amount of sodium bicarbonate added, and achieve uniform pore size and easy control. , The effect of good pore connectivity and fast liquid absorption

Active Publication Date: 2017-07-04
WUHAN DRAGONBIO ORTHOPEDIC PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the starch forms closed cells inside the polyvinyl alcohol after the polyvinyl alcohol is solidified, it is difficult to clean the starch completely, and this kind of process starch has low utilization value and high water consumption, which is not conducive to saving resources and reducing costs
In addition, the application of Chinese Patent Publication No. CN1557872 discloses "superabsorbent polyvinyl alcohol foam and its preparation method". However, the sponge product obtained by foaming has a large cell diameter and is difficult to control evenly. Because sodium bicarbonate reacts strongly and rapidly with inorganic strong acids, a large amount of gas is released instantly, and the gas escapes seriously, so carbonic acid The addition of sodium hydrogen is relatively large, and more inorganic strong acid catalysts are also consumed. This method is difficult to be applied in industrial production.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A preparation method of polyvinyl alcohol medical sponge, comprising the steps of:

[0032] (1) In parts by weight, after blending 50 parts of polyvinyl alcohol with a degree of polymerization of 1700 and a degree of alcoholysis of 99.9% and 5 parts of wheat starch, and 300 parts of distilled water into the reactor, under 50 ℃ oil bath , with a rotating speed of 100r / min, stirring and dissolving for 24 hours to obtain a mixed solution of starch and polyvinyl alcohol;

[0033] (2) Add 1 part of sodium alkylsulfonate, 1 part of glycerin, and 30 parts of hexamethylenetetramine to the above-mentioned mixed solution of starch and polyvinyl alcohol, and stir at a constant speed at a temperature of 20°C at a speed of 200r / min. 8h, obtain the second mixed solution;

[0034] (3) Add 25 parts of hydrochloric acid to the above-mentioned second mixed solution, the constant temperature of the oil bath is 20°C, and carry out the cross-linking reaction of acetalization for 6 minutes....

Embodiment 2

[0039] A preparation method of polyvinyl alcohol medical sponge, comprising the steps of:

[0040] (1) In parts by weight, 50 parts of polyvinyl alcohol with a degree of polymerization of 2000 and a degree of alcoholysis of 80% and 5 parts of cornstarch are evenly blended, and then added to the reactor with 400 parts of distilled water and heated in an oil bath at 95°C , with a rotating speed of 600r / min, stirring and dissolving for 1h to obtain a mixed solution of starch and polyvinyl alcohol;

[0041] (2) Add 0.5 parts of diglycerol polypropylene glycol ether, 0.5 parts of diethanolamine, and 30 parts of formaldehyde to the above-mentioned mixed solution of starch and polyvinyl alcohol, and stir at a constant speed of 350 r / min at a temperature of 60 ° C for 2 hours to obtain the first Two mixed solutions;

[0042] (3) Add 50 parts of hydrochloric acid to the above-mentioned second mixed solution, the constant temperature of the oil bath is 60°C, and carry out the cross-lin...

Embodiment 3

[0047] A preparation method of polyvinyl alcohol medical sponge, comprising the steps of:

[0048] (1) In parts by weight, 50 parts of polyvinyl alcohol with a degree of polymerization of 2400 and 88% degree of alcoholysis, 50 parts of polyvinyl alcohol with a degree of polymerization of 99.9% and 5 parts of wheat starch with 5 parts of polyvinyl alcohol with a degree of alcoholysis of 88% After the cornstarch is evenly blended, add 1000 parts of distilled water into the reactor, and stir and dissolve for 24 hours in an oil bath at 95°C with a rotation speed of 100r / min to obtain a mixed solution of starch and polyvinyl alcohol;

[0049] (2) Add 10 parts of sodium alkyl sulfonate, 10 parts of glycerin, and 70 parts of formaldehyde to the above-mentioned mixed solution of starch and polyvinyl alcohol, and stir at a constant speed of 8 hours at a temperature of 60° C. at a speed of 350 r / min to obtain the second mixture;

[0050] (3) Add 50 parts of sulfuric acid to the above-m...

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Abstract

The invention provides a medical polyvinyl alcohol sponge and a preparation method. The preparation method comprises the following steps: adding polyvinyl alcohol and starch into distilled water carrying out dissolving at 50 to 95 DEG C under stirring so as to obtain a mixed solution; adding a cross-linking agent, an emulsifier and a foam stabilizer into the mixed solution and carrying out stirring at 20 to 60 DEG C for 2 to 8 h so as to obtain a second mixed solution; adding an acidic catalyst into the second mixed solution and carrying out an acetalation cross-linking reaction at a constant temperature of 20 to 90 DEG C for 30 to 180 min so as to obtain emulsion-like liquid; and completion of the reaction, pouring the emulsion-like liquid into a mold, carrying out heating at 50 to 95 DEG C for curing, carrying out demoulding and washing after cooling, and then carrying out cutting and sterilization so as to obtain the medical polyvinyl alcohol sponge. The medical polyvinyl alcohol sponge prepared in the invention has a through hole structure, uniform pore diameter, good biocompatibility, excellent affinity, high porosity and fast liquid absorption rate, and is applicable to the field of surgical sciences, especially as a sponge consumable for vacuum sealing drainage.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a polyvinyl alcohol medical sponge and a preparation method thereof. Background technique [0002] Polyvinyl acetal superabsorbent sponge material (PVF sponge for short) has strong water absorption performance, high tensile strength, excellent biocompatibility, wear resistance, creep resistance, alkali resistance, good hydrophilicity, and is not easy to age And other advantages, it is widely used in the field of surgical medicine, especially in the negative pressure sealing drainage therapy, it plays the role of transmitting negative pressure and draining secretions. [0003] The sponge used in negative pressure sealing drainage therapy has many special requirements as follows: it must have a certain compressive elastic modulus to avoid hole collapse caused by negative pressure; it must have a certain pore size and a high degree of connectivity. The open pore structure of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/26C08L29/14A61L15/26A61L15/28A61L15/42
CPCA61L15/26A61L15/28A61L15/42A61L15/425C08J9/26C08J2205/04C08J2205/05C08J2207/10C08J2329/14C08L29/14
Inventor 张鸾王威
Owner WUHAN DRAGONBIO ORTHOPEDIC PROD
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