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Gold nanoflower preparing method and application of gold nanoflowers

A gold nanoflower, nanotechnology, applied in Raman scattering, inorganic inactive ingredients, material excitation analysis, etc., to achieve the effect of good biocompatibility, round and compact flower shape, and more flower shape

Inactive Publication Date: 2015-07-22
ANHUI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there is no preparation method for synthesizing gold nanoflowers in a wide pH range using chloroauric acid, polyphenols and hydrogen peroxide as raw materials at home and abroad.

Method used

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  • Gold nanoflower preparing method and application of gold nanoflowers

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Effect test

Embodiment 1

[0035] The following steps can be carried out at a temperature of 0-37°C. In this embodiment, 25°C is used, and 50 μL of 1×10 -4 Add g / mL protocatechualdehyde (molecular weight 138.12) into 500 μL sodium acetate pH7.6 aqueous solution, shake and mix; then add 1 mL of 0.005% chloroauric acid and 200 μL of 0.3% hydrogen peroxide and mix well to obtain a reaction solution; Centrifuge the reaction solution at 10000r / min for 30min, then absorb the supernatant and discard it, add double distilled water instead, repeat this three times to wash the gold nanoparticles, see TEM figure 1 a.

Embodiment 2

[0037] The following steps can be carried out at a temperature of 0-37°C. In this embodiment, 25°C is used, and 150 μL of 1×10 -4g / mL protocatechuic aldehyde was added to 500 μL sodium bicarbonate-sodium carbonate pH 8 aqueous solution, oscillated and mixed; then 1ml of 0.1% chloroauric acid and 200 μL of 0.3% hydrogen peroxide were added and mixed to obtain a reaction solution; The liquid was centrifuged at 10000r / min for 30min, then the supernatant was absorbed and discarded, and replaced with double distilled water, and this was repeated three times to wash the gold nanoparticles. See TEM figure 1 b.

Embodiment 3

[0039] The following steps can be carried out at a temperature of 0-37°C. In this embodiment, 25°C is used, and 100 μL of 1×10 -4 Add g / mL protocatechualdehyde to 500 μL sodium bicarbonate-sodium carbonate pH9.24 aqueous solution, shake and mix; then add 0.5 mL of 0.01% chloroauric acid and 200 μL of 0.1% hydrogen peroxide and mix well to obtain a reaction solution ; Centrifuge the reaction solution at 10000r / min for 30min, then absorb the supernatant and discard it, add double distilled water instead, repeat this process three times to wash the gold nanoparticles, see TEM figure 1 c.

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Abstract

The invention relates to a gold nanoflower preparing method and the application of gold nanoflowers. The preparing method comprises the following steps that 1) under room temperature, polyphenol is added to water solution with the pH value of 7-12 to obtain mixed solution; 2) chloroauric acid and hydrogen peroxide are then added in sequence, shaking up is carried out to obtain reaction solution; 3) the reaction solution is centrifuged, supernatant is abandoned, and the gold nanoflowers are obtained after washing. The particle diameters of the gold nanoflowers obtained under different pH values are 50-200nm, stability is good, the gold nanoflowers can be used in a biological body as a medicine carrier and have good biocompatibility, the gold nanoflowers can be used in chemiluminescence analysis, the signal intensity of a luminal chemiluminescence system can be obviously enhanced, the gold nanoflowers can be used in surface-enhanced Raman scattering (SERS) analysis, and the sensitivity is better than that of spherical gold nanoparticles. The gold nanoflower preparing method has the advantages that raw materials are easy to get, reaction conditions are mild, efficiency is high, speed is high, and batch preparing and producing are benefited.

Description

technical field [0001] The invention relates to the field of nanomaterial science, in particular to the preparation and application of a gold nanomaterial with a flower-like structure. Background technique [0002] Gold nanoflowers have a large specific surface area and are ideal catalyst materials; the nano-tentacles on the surface of gold nanoflowers make the surface of the same nanoparticle have many hot spots, and the significant surface-enhanced Raman scattering effect combined with good biocompatibility make it It has become an ideal choice for in-situ detection of Raman spectroscopy; finally, gold nanoflower particles have special near-infrared photothermal conversion properties due to the surface plasmon resonance absorption peak can be red-shifted to the near-infrared region. Near-infrared (NIR) hyperthermia has the advantages of non-invasiveness and no drug resistance, and has broad application prospects in the fields of tumor hyperthermia and drug loading. At pre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24A61K47/02G01N21/65
Inventor 张群林吕忱张晓悦吴亮武东
Owner ANHUI MEDICAL UNIV
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