The invention discloses a liquid cooling integration box air tightness detection device in the technical field of air tightness detection devices, and the device comprises a supporting bottom plate, the left and right sides of the top of the supporting bottom plate are vertically provided with supporting side plates, the tops of the supporting side plates are horizontally provided with a supporting top plate, and the center of the top of the supporting bottom plate is provided with a detection box body. The upper part of the left side wall of the detection box body is communicated with an air pressure detection meter, at the moment, a first air supply pipe is controlled to pressurize the inner cavity of the liquid cooling integrated box body through a second air supply pipe, and meanwhile, whether bubbles are generated in the water body in the inner cavity of the detection box body and whether the pressure value changes are observed; therefore, the air tightness of the liquid-cooled integrated box body is judged, the position of a specific crack is convenient to observe, the detection efficiency is improved, compared with a simple air tightness detection result, the detection result is more visual and clear, the problem is convenient to find and improve, the operation is simple and convenient, and the popularization of the liquid-cooled integrated box body air tightness detection device is facilitated.