The invention provides an image mosaic method and device and a storage medium. The method comprises the following steps: positioning the overlapping region of two images to be stitched, obtaining theinformation of the overlapping region, dividing the two overlapping sub-images into blocks in the boundary line of the overlapping region, obtaining the pair of the sub-images of the overlapping region, and directionally registering the feature points to obtain the feature point set of the overlapping region; According to the optimized TPS thin plate spline function, the feature point set is calculated, two deformation images to be fused are obtained, the deformation sub-image pairs corresponding to the boundary line of the overlapping region in the deformation image to be fused are obtained,the pixel position information of the deformation sub-image pairs is mapped to the unit circle, and the smooth transition process is carried out, so as to obtain the overlapping region image. The invention extracts feature points in the overlapping area, which improves the efficiency of feature extraction and the accuracy of matching. Using the optimized TPS function to deform the original image,the problem of ghost and deformation is restrained effectively. Adaptively smoothing pixel value of unit circle solves the problem of chromatic gap.