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39results about How to "Strong analgesic activity" patented technology

Alpha-conotoxin peptide, and medical composition, preparation method and purpose thereof

The invention belongs to the fields of biochemistry and molecular biology, relates to an alpha-conotoxin peptide, and a medical composition, a preparation method and a purpose thereof, also relates to a propeptide of the conotoxin peptide, a nucleic acid construct, an expression vector, a transformed cell and a fusion protein, and also relates to a method for blocking acetylcholine receptors and a pharmaceutical purpose of the conotoxin peptide. The alpha-conotoxin peptide can specifically block the acetylcholine receptors (nAChRs) (such as alpha3beta2 nAChR), has high analgesic activity and addiction withdrawal activity and has a good application prospect in the aspects of preparing analgesics, smoking cessation or drug treatment medicines and the like.
Owner:HAINAN UNIVERSITY

Alpha-type conus polypeptide and application thereof

InactiveCN101792485AStrong analgesic activityIncreased pain thresholdNervous disorderPeptide/protein ingredientsConusConus genus
The invention discloses alpha-type conus polypeptides and application thereof. The invention provides seven polypeptides: in the polypeptide I, an amino acid sequence is disclosed by a sequence 7 in a sequence table, and the last amino acid residue is amidated; in the polypeptide II, an amino acid sequence is disclosed by a sequence 8 in the sequence table, and the last amino acid residue is amidated; in the polypeptide III, an amino acid sequence is disclosed by a sequence 9 in the sequence table, and the last amino acid residue is amidated; in the polypeptide IV, an amino acid sequence is disclosed by a sequence 10 in the sequence table, and the last amino acid residue is amidated; in the polypeptide V, an amino acid sequence is disclosed by a sequence 11 in the sequence table, and the last amino acid residue is amidated; in the polypeptide VI, an amino acid sequence is disclosed by a sequence 12 in the sequence table, and the last amino acid residue is amidated; and in the polypeptide VII, an amino acid sequence is disclosed by a sequence 13 in the sequence table. By the determination of activity, the seven polypeptides of a general formula I have abirritation, wherein the alpha-type conus polypeptides T-1, T-2, T-3 and T-4 have obvious analgesic activity, T5-T7 also have obvious analgesic activity, and the alpha-type conus polypeptides have application value in an analgesic aspect.
Owner:INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE

Three alpha-conus polypeptides and use thereof

The invention discloses alpha-conus polypeptides and use thereof. The invention provides seven polypeptides: a polypeptide I of which the amino acid sequence is represented by a sequence 7 in a sequence table and in which the last amino acid residue is amidated; a polypeptide II of which the amino acid sequence is represented by a sequence 8 in the sequence table and in which the last amino acid residue is amidated; a polypeptide III of which the amino acid sequence is represented by a sequence 9 in the sequence table and in which the last amino acid residue is amidated; a polypeptide IV of which the amino acid sequence is represented by a sequence 10 in the sequence table and in which the last amino acid residue is amidated; a polypeptide V of which the amino acid sequence is representedby a sequence 11 in the sequence table and in which the last amino acid residue is amidated; a polypeptide vI of which the amino acid sequence is represented by a sequence 12in the sequence table andin which the last amino acid residue is amidated; and a polypeptide VII of which the amino acid sequence is represented by a sequence 13 in the sequence table and in which the last amino acid residueis amidated. The result of activity tests, the seven polypeptides of the general formula (I) have pain relieving effect, alpha-conus polypeptides T-1, T-2, T-3 and T-4 have obvious pain-relieving activity, and the alpha-conus polypeptides T-5, T-6 and T-7 also have obvious pain-relieving effect, and the alpha-conus polypeptides have application values in pain-reliving aspect.
Owner:INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE

A kind of α-type conus polypeptide and its application

InactiveCN102286079AStrong analgesic activityIncreased pain thresholdPeptide/protein ingredientsAntipyreticConotoxinPeptide T
The invention discloses seven alpha type conotoxin peptides and applications thereof. The peptide I has an amino acid sequence shown as the sequence 7 in a sequence table, and the last amino acid residue is amidated; the peptide II has an amino acid sequence shown as the sequence 8 in the sequence table, and the last amino acid residue is amidated; the peptide III has an amino acid sequence shownas the sequence 9 in the sequence table, and the last amino acid residue is amidated; the peptide IV has an amino acid sequence shown as the sequence 10 in the sequence table, and the last amino acidresidue is amidated; the peptide V has an amino acid sequence shown as the sequence 11 in the sequence table, and the last amino acid residue is amidated; the peptide VI has an amino acid sequence shown as the sequence 12 in the sequence table, and the last amino acid residue is amidated; and the peptide VII has an amino acid sequence shown as the sequence 13 in the sequence table. Proved by determination of activity, the seven peptides shown as a general formula I have an analgesic effect, wherein alpha type conotoxin peptides T-1, T-2, T-3 and T-4 have remarkable analgesic activity, and thealpha type conotoxin peptides T5-T7 also have remarkable analgesic activity, and the application value on the aspect of analgesia is achieved.
Owner:INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE

Chinese hard tick neuropeptide and its preparing method and use

The present invention belongs to the field of biomedicine technology. Chinese hard tick neuropeptide is a kind of single-stranded small peptide obtained from the ganglion of Chinese hard tick and with molecular weight of 1005.22 dalton, isoelectric point of 8.59, and the first order whole sequence structure of NH2-LVVYPWTK-COOH. It is prepared through adhering Chinese hard tick to the bottom of watch glass and on ice for 20 min, cutting along back side to eliminate ganglion, homogenizing, centrifuging and eliminate precipitate, filtering with membrane, and twice reverse high efficiency liquid phase chromatographic separation and purification. The Chinese hard tick neuropeptide has powerful analgetic activity, and may be used as analgetic medicine.
Owner:KUNMING INST OF ZOOLOGY CHINESE ACAD OF SCI

Alpha type conotoxin peptides and applications thereof

InactiveCN102286079BStrong analgesic activityIncreased pain thresholdPeptide/protein ingredientsAntipyreticConotoxinPeptide T
The invention discloses seven alpha type conotoxin peptides and applications thereof. The peptide I has an amino acid sequence shown as the sequence 7 in a sequence table, and the last amino acid residue is amidated; the peptide II has an amino acid sequence shown as the sequence 8 in the sequence table, and the last amino acid residue is amidated; the peptide III has an amino acid sequence shownas the sequence 9 in the sequence table, and the last amino acid residue is amidated; the peptide IV has an amino acid sequence shown as the sequence 10 in the sequence table, and the last amino acidresidue is amidated; the peptide V has an amino acid sequence shown as the sequence 11 in the sequence table, and the last amino acid residue is amidated; the peptide VI has an amino acid sequence shown as the sequence 12 in the sequence table, and the last amino acid residue is amidated; and the peptide VII has an amino acid sequence shown as the sequence 13 in the sequence table. Proved by determination of activity, the seven peptides shown as a general formula I have an analgesic effect, wherein alpha type conotoxin peptides T-1, T-2, T-3 and T-4 have remarkable analgesic activity, and thealpha type conotoxin peptides T5-T7 also have remarkable analgesic activity, and the application value on the aspect of analgesia is achieved.
Owner:INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE

Medicine composition for treating nephritis

The invention discloses a traditional Chinese medicine composition for treating nephritis, and belongs to the technical field of medicines. The medicine composition is prepared from the following components: corn silk, cherokee rose fruit, herba houttuyniae, spreading hedyotis herb, lily, Chinese wolfberry, Chinese-date, peach kernel, eucommia, lalang grass rhizome, shizandra berry, white mulberry root-bark, black soybean, and liquorice. The traditional Chinese medicine composition has an excellent curative effect on treating or preventing the acute nephritis, and the medicine side effect is low, so that the traditional Chinese medicine composition has a remarkable clinical promotional value.
Owner:崔新明

Application of triterpenoid saponin compound and salt of triterpenoid saponin compound

The invention provides application of a triterpenoid saponin compound to preparation of analgesics, and particularly relates to application of a triterpenoid saponin compound shown in a formula I fortreatment of neuralgia, bone pain, muscle pain, pain caused by traumatic injury, headache, stomach pain, intestinal colic, biliary colic, renal colic and cancer pain. (Please see the specification forthe formula I). In the formula I, R1=H, glu, R2=H, OH. The invention further discloses application of a salt of the compound of the formula I to the preparation of the analgesics. The triterpenoid saponin compound can be a naturally existing organic compound or a synthetic organic compound, has strong analgesic activity, and is used as an active ingredient for preparing the analgesics or a pharmaceutical composition together with pharmaceutically acceptable carriers or excipients.
Owner:YUNNAN MINZU UNIV

A method of using silkworm to prepare analgesic polypeptide

The invention discloses a method for preparing analgesic polypeptide from silkworms and belongs to the field of gene engineering. The preparation method comprises steps as follows: a conotoxin omega-MVIIA gene sequence is optimized according to BmNPV (Bombyx mori Nucleopolyhedrovirus) codon usage frequency, genes obtained after chemical synthesis are linked to a donor plasmid pFastBacDual and introduced to EGFP (enhanced green fluorescent protein) genes, and a recombinant donor plasmid pFBD-MVIIA / EGFP is established. MVIIA / EGFP is transposed to BmNPV with a Bac-to-Bac method, and a recombinant virus vBmMVIIA / EGFP is formed. DNA of the recombinant virus is transfected to cells of the silkworms, BV particles are obtained and injected into the silkworms at 200 pfu after the titer of the BV particles is tested by the aid of green fluorescence, and blood of the silkworms is collected after five days of transfection. Acetic-acid-induced mouse writhing experiments show that the blood of the silkworms infected with expressed conotoxin omega-MVIIA has remarkable analgesic activity, and the number of the average writhing times is only 3.55 and is remarkably higher than 37.30 in a control group of mice injected with normal saline. A new method is provided for expression of conotoxin omega-MVIIA with analgesic activity, and has potential application value.
Owner:JIANGSU UNIV

Three alpha-conus polypeptides and use thereof

The invention discloses alpha-conus polypeptides and use thereof. The invention provides seven polypeptides: a polypeptide I of which the amino acid sequence is represented by a sequence 7 in a sequence table and in which the last amino acid residue is amidated; a polypeptide II of which the amino acid sequence is represented by a sequence 8 in the sequence table and in which the last amino acid residue is amidated; a polypeptide III of which the amino acid sequence is represented by a sequence 9 in the sequence table and in which the last amino acid residue is amidated; a polypeptide IV of which the amino acid sequence is represented by a sequence 10 in the sequence table and in which the last amino acid residue is amidated; a polypeptide V of which the amino acid sequence is representedby a sequence 11 in the sequence table and in which the last amino acid residue is amidated; a polypeptide vI of which the amino acid sequence is represented by a sequence 12in the sequence table andin which the last amino acid residue is amidated; and a polypeptide VII of which the amino acid sequence is represented by a sequence 13 in the sequence table and in which the last amino acid residueis amidated. The result of activity tests, the seven polypeptides of the general formula (I) have pain relieving effect, alpha-conus polypeptides T-1, T-2, T-3 and T-4 have obvious pain-relieving activity, and the alpha-conus polypeptides T-5, T-6 and T-7 also have obvious pain-relieving effect, and the alpha-conus polypeptides have application values in pain-reliving aspect.
Owner:INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE
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