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A kind of plant extract and its preparation method and application

A technology of extracts and drugs, applied in the field of goosegrass extract and its preparation, can solve the problems of goosegrass and its extracts that have not been seen yet, achieve good application prospects, reduce the number of errors, and facilitate large-scale industrial production Effect

Active Publication Date: 2021-11-23
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there have been no reports of goosegrass and its extracts on analgesia, improvement of learning and memory, and prevention or treatment of Alzheimer's disease

Method used

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  • A kind of plant extract and its preparation method and application
  • A kind of plant extract and its preparation method and application
  • A kind of plant extract and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: the preparation of goosegrass extract

[0032] 1kg of goosegrass was crushed, added 5000mL of hot water to reflux and extracted twice, each time for 1h, after filtration, the filtrate was concentrated to 1000mL. Then add 3000mL of ethanol, stir well, let it stand, filter, and concentrate the filtrate until it has no alcohol smell. Adsorbed by D101 macroporous resin, the resin dosage is 10kg, eluted with 5000mL deionized water, combined with water eluent, concentrated and dried to obtain 172g of goosegrass extract.

Embodiment 2

[0033] Embodiment 2: HPLC-MS component analysis of goosegrass extract

[0034] Drugs: acetonitrile (Beijing Merida Technology Co., Ltd.), formic acid (Guangzhou Chemical Reagent Factory), and goosegrass extract were prepared by the method described in Example 1-2.

[0035] Instrument: Agilent 6210LC / MSD TOF liquid mass spectrometer; Chromatographic column: Cosmosil-5C18-MS-II (4.6×250mm, 5μm); Column temperature: 30℃; Flow rate: 1mL / min; Injection volume: 20μL; Phase: acetonitrile (B)-0.1% formic acid water (A); Elution condition: 20% acetonitrile-80% formic acid water isocratic elution; mass spectrometry acquisition mode: positive ion mode; cone voltage: 3000V; ion source temperature: 350°C; nitrogen flow rate: 10ml / min; mass range: 50-2000Da.

[0036] Determination according to law, the measured fingerprints see figure 1 , the obtained goosegrass extract fingerprint contains components such as betaine and choline.

Embodiment 3

[0037] Embodiment 3: HPLC-ELSD component analysis of goosegrass extract

[0038] Drugs: acetonitrile (Beijing Merida Technology Co., Ltd.), formic acid (Guangzhou Chemical Reagent Factory), and goosegrass extract were prepared by the method described in Example 1-2.

[0039] Instrument: Waters e2695; Chromatographic column: Cosmosil-5C18-MS-II (4.6×250mm, 5μm); Column temperature: 30℃; Flow rate: 1mL / min; Injection volume: 20μL; Mobile phase: Acetonitrile (B)-0.1 % formic acid water (A); elution conditions: 0-10min 5%-95%B, 10-15min 95%B; ELSD drift tube temperature: 80°C; gain: 40; gas pressure: 40psi; mode: cooling. Determination according to law, the measured fingerprints see figure 2 , the obtained goosegrass extract fingerprint contains components such as betaine and choline.

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Abstract

The invention relates to a goosegrass extract and a preparation method thereof. The extract is widely used in medicines and health products for analgesia, improvement of learning and memory functions, prevention or treatment of Alzheimer's disease. The extract used in the invention has extensive and cheap plant resources, and its preparation process is simple and easy for large-scale production.

Description

technical field [0001] The invention relates to a plant extract capable of relieving pain, improving learning and memory ability, and preventing or treating Alzheimer's disease, in particular to a goosegrass extract and its preparation method and application. Background technique [0002] Pain is an unpleasant sensory and emotional experience resulting from tissue damage or potential tissue damage, with serious physical and psychological consequences for patients. Currently, chemical drugs are used clinically to treat various pains, which can be roughly divided into two categories according to their targets: opioid drugs include pethidine and morphine, etc., and non-opioid drugs include aspirin and indomethacin. The former has rapid analgesic effect and obvious curative effect, but its clinical use is often limited due to addiction and tolerance; while the latter has poor effect on severe pain and is limited to the treatment of mild pain. Therefore, there is an urgent need ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P25/28A61P29/00A61P25/00
CPCA61K36/899A61K2236/331A61K2236/55A61P25/00A61P25/28A61P29/00
Inventor 叶文才王英王国才范春林吴振龙黄永和陈伟明李勇曾瑚瑚
Owner JINAN UNIVERSITY
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