The present invention provides a
clarithromycin dispersible tablet preparation method, which comprises: carrying out ultrafine crushing on
clarithromycin and part of
lactose into micro-
powder with the
diameter of less than 10 [mu]m to obtain mixed
powder A; taking the remaining filler and part of a disintegrant, and mixing to form mixed
powder B; mixing an
adhesive and
purified water to prepare an
aqueous solution with the
mass fraction of 1-10%; mixing the mixed powder B with the mixed powder A in an equal increase manner, placing into a three-dimensional mixer to mix for 30-40 min, adding to the
adhesive aqueous solution to prepare a soft material, and screening with a 16-24 mesh
sieve;
drying at a temperature of 50-70 DEG C, and screening the whole particle with a 16-24 mesh
sieve; externally adding the remaining disintegrant, a
lubricant and a sweetener to the particles to obtain a material C; and
tableting the material C to obtain the
clarithromycin dispersible tablets. According to the invention, the clarithromycin and part of the
lactose are subjected to ultrafine crushing, such that the particle size is small, the specific surface area is increased, the adsorption property and the
solubility are correspondingly increased, the bitterness of the product can be reduced, and the
patient compliance can be improved; and with the process, the clarithromycin
dispersible tablet with characteristics of stable quality, rapid
drug dissolution and no bad
odor can be prepared.