Oseltamivir phosphate oral liquid and preparation method thereof
A technology of oseltamivir phosphate and Wei oral liquid, which is applied in the direction of pharmaceutical formulations, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., which can solve the problem of inability to ensure the safety of drug administration and unsuitable capsule dosage forms. , difficult to accurately administer and other problems, to achieve the effect of convenient carrying and taking, easy storage, and stable quality
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Embodiment 1
[0028] Raw materials for oseltamivir phosphate oral liquid: 0.3g oseltamivir phosphate, 0.044g co-solvent, 0.03g aspartame, 0.03g stabilizer, 0.03g ethyl p-hydroxybenzoate, 90g distilled water.
[0029] The co-solvent is prepared by mixing 0.11g sodium carboxymethylcellulose, 0.11g propylene glycol, 0.11g maltitol, and 0.11g poloxamer 188.
[0030] The stabilizer is prepared by mixing 0.02g of hydroxypropylmethylcellulose, 0.005g of sodium alginate and 0.005g of disodium glutarate.
[0031] Oseltamivir phosphate oral liquid is prepared by the following method:
[0032] Add the cosolvent into distilled water and stir evenly; then add oseltamivir phosphate and stir evenly; then add aspartame, stabilizer and ethyl p-hydroxybenzoate, mix evenly to obtain a mixed solution; finally mix the mixed solution at 115 Sterilize at ℃ for 18 minutes to obtain the oseltamivir phosphate oral liquid, which is divided into 15ml / bottle after cooling.
Embodiment 2
[0034] Prepare by the method of embodiment 1, difference is only in:
[0035] The co-solvent is replaced by a mixture of propylene glycol, maltitol and poloxamer 188 in a mass ratio of 1:1:1.
Embodiment 3
[0037] Prepare by the method of embodiment 1, difference is only in:
[0038] The co-solvent is replaced by a mixture of sodium carboxymethylcellulose, maltitol and poloxamer 188 in a mass ratio of 1:1:1.
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