The invention relates to a process in the field of pharmacy, in particular to a process for realizing continuous production of a freeze-dried product. A continuous production process for a freeze-dried preparation sequentially comprises the following steps of: washing bottles by using a bottle washing machine, drying and sterilizing with a tunnel sterilizing and drying oven, bulking with a liquid bulking semi-corker, freeze-drying and pressing with freeze-drying machines, and performing cover rolling, lamp inspection, labeling, boxing and packing through a cover rolling machine, a lamp inspection machine, a labeling machine and a boxing and packing machine respectively to obtain a finished product. The bottle washing machine, the tunnel sterilizing and drying oven, the liquid bulking semi-corker, the freeze-drying machines, the cover rolling machine, the lamp inspection machine, the labeling machine and the boxing and packing machine are arranged linearly; the number of the freeze-drying machines is more than two, and the freeze-drying machines are arranged linearly; and the freeze-drying box is provided with front and rear doors facing an operator. The process is an improvement of the prior art, and has the advantage of skillfully solving the pollution and waiting problems in boxing and un-boxing so that the boxing and the un-boxing do not interfere with each other.