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Continuous production process for freeze-dried preparation

A production process and technology of freeze-dried preparations, which are applied in the field of continuous production of freeze-dried products, can solve the problems of increasing aseptic rooms, which cannot be realized, and achieve the effect of solving the risk of contamination

Active Publication Date: 2011-04-27
KUNMING LONGJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

This method firstly needs to increase the aseptic room, secondly, the product cannot avoid the possibility of contamination, and thirdly, the product has special requirements on the filling time, and it cannot be realized

Method used

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  • Continuous production process for freeze-dried preparation

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Effect test

Embodiment Construction

[0012] To freeze-dry a certain freeze-dried product, the production capacity of bottle washing machine, tunnel sterilization oven, and liquid filling semi-corking machine is 400 bottles / min (2ml vials), and there are 4 sets of freeze-drying machines (each 30m 2 It can hold 2ml vials (140,000 vials), the dispensing time of this product is 1.5 hours, and the freeze-drying cycle is 20 hours. The whole process time is as follows:

[0013] On the first day, the medicines are dispensed from 8:00-9:30, the bottles are washed at 9:00, and the filling starts at 10:00. The first lyophilizer was filled and cleared at 16:00; the second lyophilizer was filled and cleared at 18:00; the third lyophilizer was filled and cleared at 2:00 the next day. Filling was completed at 8:00 and the site was cleared; the fourth unit was filled at 10:00, and the site was filled and cleared at 16:00. At the same time, the first box was released at 12:00 the next day, and the box was cleared at 16:00; the f...

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Abstract

The invention relates to a process in the field of pharmacy, in particular to a process for realizing continuous production of a freeze-dried product. A continuous production process for a freeze-dried preparation sequentially comprises the following steps of: washing bottles by using a bottle washing machine, drying and sterilizing with a tunnel sterilizing and drying oven, bulking with a liquid bulking semi-corker, freeze-drying and pressing with freeze-drying machines, and performing cover rolling, lamp inspection, labeling, boxing and packing through a cover rolling machine, a lamp inspection machine, a labeling machine and a boxing and packing machine respectively to obtain a finished product. The bottle washing machine, the tunnel sterilizing and drying oven, the liquid bulking semi-corker, the freeze-drying machines, the cover rolling machine, the lamp inspection machine, the labeling machine and the boxing and packing machine are arranged linearly; the number of the freeze-drying machines is more than two, and the freeze-drying machines are arranged linearly; and the freeze-drying box is provided with front and rear doors facing an operator. The process is an improvement of the prior art, and has the advantage of skillfully solving the pollution and waiting problems in boxing and un-boxing so that the boxing and the un-boxing do not interfere with each other.

Description

technical field [0001] The invention relates to a process method in the pharmaceutical field, in particular to a process method capable of realizing continuous production of freeze-dried products. Background technique [0002] In the current conventional freeze-dried preparation production line, the process steps are: bottle washing machine washing, tunnel sterilization oven drying and sterilization, liquid filling semi-cork machine (liquid filling machine) filling, freeze-drying machine freeze-drying Press the plug, and then go through the capping machine (sealing machine), light inspection machine, labeling machine, and box packing machine to perform capping, light inspection, labeling, and box packaging respectively to obtain the finished product. Often a bottle washing machine, a tunnel sterilization oven machine, a filling semi-corking machine (filling machine) and one or two freeze drying machines with a single door are used. In order to avoid pollution during producti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/00
Inventor 樊献俄王发祥钱应璞郑效东魏娜谭世和
Owner KUNMING LONGJIN PHARMA
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