The invention relates to a preparation method of (S)-(+)-3,4,8,8a-tetrahydro-8a-methyl-1,6-(2H,7H)-
naphthoquinone. According to the preparation method, an L-
proline derivative is used as a chiral catalyst and
microwave radiation is introduced into chiral preparation of the (S)-(+)-3,4,8,8a-tetrahydro-8a-methyl-1,6-(2H,7H)-
naphthoquinone for the first time through asymmetric Robinson cyclization reaction under conventional conditions or
microwave irradiation conditions. Under proper power, an L-prolinamide type catalyst can keep excellent
catalysis performance and the
catalysis reaction time isshortened; compared with room-temperature stirring conditions, the synthesis efficiency is greatly improved. The molecular collision is aggravated through the
microwave radiation and an intermediatecan more easily pass through an energy barrier to form a
transition state, so that the reaction time is remarkably shortened, the preparation efficiency of the (S)-(+)-3,4,8,8a-tetrahydro-8a-methyl-1,6-(2H,7H)-
naphthoquinone is greatly improved and the
synthesis period is shortened. The method is low in cost, simple and rapid, high in yield and good in
stereoselectivity.