The invention discloses special medicine use formula nutrition powder for a tumor patient and a preparation method thereof, and relates to the technical field of special medicine use formula food. Thenutrition powder is prepared from, by weight, 120-964 parts of protein, 130-1040 parts of fat, 139-1112 parts of carbohydrate, 66-530 parts of composite mineral substances, 2.53-20.2 parts of multi-vitamins, 0.4-3.2 parts of taurine, 0.5-4 parts of mono-diglycerides fat substance acid, 0.09-0.72 part of nucleotide, 0.06-0.48 part of L-carnitine, 9-72 parts of a composite thickening agent, 1-8 parts of concentrated vanilla and 0.15-1.2 parts of Aspartame. The formula food contains seven nutrients required by the human body, has the advantages of high protein, high fat and low carbohydrates, conforms to the metabolic characteristic of the tumor patient, selectively starves tumor cells and maintain the functions of normal cells, and improves the living quality of the patient.