The invention discloses an Internet of Things information security chip, comprising a central processing unit, a dynamic memory, a flash memory, an SM2 encryption algorithm unit, an SM3 encryption algorithm unit, an SM4 encryption algorithm unit, an AES encryption algorithm unit, a true random Number generator, physical unclonable function circuit, I2C interface, UART interface, SPI interface, I / O port, JTAG interface and timer; true random number generator is used to generate true random numbers, and physical unclonable function circuit is used for chip authentication and key generation, when the key needs to be used, the true random number generated by the true random number generator is input to the physical unclonable function circuit through the on-chip bus, and the physical unclonable function circuit outputs a unique response sequence, the response sequence is key. The encryption and decryption operation speed of the invention is faster, the consumption of hardware resources and power consumption is less, the key cannot be copied and stolen, and the security and anti-counterfeiting level is higher.