The invention discloses a disinfecting and cleaning device for nursing equipment for hemodialysis nursing. The disinfecting and cleaning device comprises a first box body, a holding rod, a cleaning towel, a water bin and a disinfectant bin, wherein a second box body is installed at the lower end of the first box body, a notch is formed in the outer wall of the front face of the second box body, a hand wheel is connected to the right side face of the second box body, a bracket is installed on the lower surface of the second box body, the holding rod is arranged at an opening in the upper end of a branch pipe, a second three-way valve is installed in the middle of the holding rod, the cleaning towel is wound around the outer surface of the second box body, an ultraviolet sterilization lamp is installed on the inner top face of the second box body, the water bin is installed on the right side in the first box body, a water pipe penetrates through the interior of the water bin, the disinfectant bin is installed on the left side of the interior of the first box body, and a stirring shaft is installed in the disinfectant bin. According to the invention, the two different sprayers are arranged, large-area spraying of disinfectant is facilitated, the surface of the nursing equipment can be flushed through high-pressure water columns, and the nursing equipment is more flexible and convenient to use.