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44results about How to "Improved Healing Accuracy" patented technology

Apparatus for generating multi-energy x-ray images and methods of using the same

Apparatus for generating multi-energy x-ray images and systems and methods for processing and using multi-energy x-ray images are provided for treating a target, e.g., a tumor, for image-guided radiation therapy. An image-guided radiation therapy system is provided including a treatment delivery system, a multi-energy imaging system, and a system processor. The treatment delivery system includes a radiation source configured to generate treatment radiation beams. The multi-energy imaging system is configured to generate a first set of image data of the patient using imaging radiation at a first energy level and a second set of image data of the patient using imaging radiation at a second energy level. The system processor is configured to process the first and second sets of image data to generate an enhanced image of the patient and to direct the treatment delivery system based on information obtained from the enhanced image.
Owner:ACCURAY

Ophthalmologic laser system

An ophthalmological laser system for photodisruptive irradiation of ocular tissue, including a crystalline lens or a cornea. The system includes an ultra-short pulse laser, the radiation of which is focusable as illumination light via an illumination beam path including a scanner unit and focusing optics. A control unit is programmed to execute determining irradiation control data for photodisruptions at irradiation points in an interior of the ocular tissue distributed three-dimensionally and non-equidistantly to create at least one predetermined target incision. The laser system then irradiates the ocular tissue according to the determined irradiation control data.
Owner:CARL ZEISS MEDITEC AG

Radiotherapy system

The invention relates to a radiotherapy system, which comprises a treatment head, a treatment head supporting frame, a rotary mechanism for driving the treatment head, a treatment bed and a CT imaging device, wherein the CT imaging device comprises a CT imaging ring, a CT drive mechanism connected with the CT imaging ring and a CT supporting frame for supporting the CT imaging ring; the radiotherapy system also comprises a shared bracket; the treatment head supporting frame is connected with the shared bracket by a bearing; the CT supporting frame is connected with the shared bracket by a Z-direction guide rail in the vertical direction and a X-direction guide rail in the horizontal direction; the treatment bed comprises a base and a human body supporting plate; the human body supporting plate is connected with the base by a Y-direction guide rail along the direction of a shaft line of a central hole of the CT imaging ring; the base is fixedly connected with the CT supporting frame; and the shared bracket, the treatment head supporting frame and the CT supporting frame are all provided with spaces for the treatment bed to pass through and are communicated with the central hole of the CT imaging ring. The radiotherapy system solves the technical problem that the CT imaging device and the treatment head rotate at the same time to cause poor imaging effect of the CT imaging device and the spaces of the CT imaging device and the treatment head are incompatible so as to influence an effect.
Owner:宋世鹏 +1

Near-distance image navigation full-automatic radioactive particle implanting device

The invention discloses a near-distance image navigation full-automatic radioactive particle implanting device which comprises a puncture needle puncture module, a radioactive particle implanting module and a puncture needle rotating module. The puncture needle rotating module comprises a puncture needle, a puncture needle clamping head and a puncture needle rotating wheel which are coaxially arranged, a puncture needle rotating wire is wound on the puncture needle rotating wheel, the radioactive particle implanting module comprises a fixing barrel which supports the puncture needle rotating wheel and is in rotatable connection with the same, a radioactive particle clip is fixed on one side of the fixing barrel and communicated with the puncture needle, the front portion of a flexible probe wound on a probe driving wheel body is mounted in the puncture needle in an inserted manner, a probe driving wire is wound on a probe driving wheel, the puncture needle puncture module comprises a slider fixedly connected with the fixing sleeve, and the slider is connected with a spiral transmission module which is driven by a screw rotating wire. The near-distance image navigation full-automatic radioactive particle implanting device is high in radioactive particle implanting accuracy and high in speed, and damage to doctors by radioactive operating environment can be lowered.
Owner:TIANJIN UNIV

Diagnostic Method, Method for Validation of Diagnostic Method, and Treatment Method

A method is disclosed for diagnosing and treating a patient having lesions in both arteries of left and right lower limbs. By determining that a lesion distal to an aortailiac bifurcation is to be treated first, catheters and an operation time can be reduced is to be treated first on a priority basis based on diagnostic data, deciding that a lesion proximal to the bifurcation is to be treated next, then treating the lesions substantially continuously.
Owner:TERUMO KK

Laser engraving devcie

A laser engraving device which can adjust its machining position is disclosed. The device includes a laser machine for supplying laser beam, a guide rod adjacent to and parallel to the laser machine, a galvanometric scanner coupled to the guide rod and being movable with the guide rod, and a driver disposed at an end of the guide rod for driving the guide rod.
Owner:LEGEND LASER

Radiotherapy device for stereo positioning of head

The invention discloses a radiotherapy device for stereo positioning of a head. An X-ray transmitter and a digital image detection panel are integrated on an accelerator, a three-dimensional image of a patient can be quickly obtained through a cone beam computed tomography (CBCT) function, and after the three-dimensional image is obtained, software quickly locates tumor coordinates in a data set on isocenters through an algorithm; and because the technical scheme is unique in structure, the three-dimensional image of the patient can be quickly obtained through only rotating the CBCT for 120 degrees, the consumed time is short, so a plurality of groups of three-dimensional images of the patient can be obtained during a time period, tumor position variations which are caused by breathing movement can be recorded in the plurality of groups of images, the tumor positions (registration) of the plurality of three-dimensional images are compared through the algorithm, and a four-dimensional plan is designed in a radio therapy planning system according to the displacement differences of the images groups.
Owner:SUZHOU LINATECH MEDICAL SCI & TECH CO LTD

Radiation therapy system

InactiveCN102309824ASolve the technical problem of poor imaging effectImproved Healing AccuracyComputerised tomographsTomographyX-rayRadiation therapy
The invention relates to a radiation therapy system, comprising a therapy head, a therapy head driving mechanism, a therapy bed, a shared bracket, a therapy head support frame and a CT (Captive Test) imaging device, wherein the CT imaging device comprises an X ray bulb tube, a CT supporting ring, a CT driving mechanism, a probe and a signal conversion system; one side of the therapy head support frame is connected with a shared bracket bearing, and the other side is connected with the therapy head; one side of the CT supporting ring is connected with the shared bracket bearing; the X ray bulb tube and the probe are oppositely arranged on the other side of the CT supporting ring; the middle holes of the shared bracket, the therapy head support frame and the CT supporting ring are communicated; the therapy bed can move in the middle holes of the shared bracket, the therapy head support frame and the CT supporting ring; the CT driving mechanism drives the CT supporting ring to rotate; and the therapy head driving mechanism drives the therapy head support frame to rotate. According to the radiation therapy system, the technical problem of poor imaging effect of the CT imaging device because the CT imaging device and the therapy head in the radiation therapy system with the traditional CT imaging device simultaneously rotate can be solved.
Owner:SHANGHAI SONGS LAB TECH DEV +1

Biofeedback apparatus for treating odontoprisis

The invention provides a biofeedback apparatus for treating odontoprisis, which comprises an upper jaw biteplate (100), a sensing transmitting device (200) and a receiving controller (300), wherein the sensing transmitting device (200) is arranged in the upper jaw biteplate (100); and the sensing transmitting device (200) and the receiving controller (300) are connected. The biofeedback apparatus for treating odontoprisis is designed on the basis of two main factors, namely biting and nerves, directly monitors and acquires the signal of a pressure produced by an tooth grinding action, slightly wakes a patient by means of vibration and can be carried and used at home to provide objective and scientific data for the treatment and monitoring of the odontoprisis.
Owner:魏小龙 +2

Microwave excitation source with self-fixed amplitude technology used for high-energy medical electron accelerator

InactiveCN107529270AResponsiveness for precise waveform amplitude controlAmplitude Stability ImprovementAcceleratorsAutomatic controlHigh energy
The invention relates to a medical electron accelerator technology, in particular to a microwave excitation source with self-stabilizing amplitude technology for a high-energy medical electron accelerator, including a linear power supply for system power supply, including a reference oscillator and a phase-locked source connected in sequence , electronically controlled attenuator, modulation switch, pre-amplifier, high power amplifier, isolator, power coupling unit, power monitoring module II and control main board, said control main board includes A / D and D / A modules and main control The signal output terminal of the power monitoring module II is connected to the A / D and D / A module, the control output terminal of the A / D and D / A module is connected to the electronic control attenuator, and the A / D and D / A module The communication port of the main controller is connected with the main controller MCU, the main controller MCU is connected with the display unit, and the modulation switch is also connected with the timing controller. The invention can carry out real-time power amplitude control through its own automatic control unit, so that the output power of the excitation source can be monitored in real time and automatically calibrated.
Owner:SHINVA MEDICAL INSTR CO LTD

Method for preparing core-shell structure drug carrier with near-infrared light remote response and application thereof

The invention discloses a method for preparing a core-shell structure drug carrier with near-infrared light remote response and an application thereof, belongs to the field of biomedical materials, and particularly discloses a method for preparing a core-shell structure drug carrier with near-infrared light remote response and an application thereof. The invention aims at solving the problems of shallow light source penetration depth, high cost and big risk of the current atherosclerosis traditional photodynamics therapy. The method comprises the following steps: firstly synthesizing a core-shell structure nano-particle coated with a photosensitizer, wherein the nano-particle is swallowed by the cell in the cell co-culture process; and radiating the cell by near-infrared light, wherein under the stimulation of the near-infrared light, the nano-particle in the cell is acted with the tissue oxygen to generate a cytotoxic active oxygen molecule singlet oxygen (1O2) so as to kill the cell till apoptosis. The core-shell structure drug carrier with near-infrared light remote response prepared by the invention is taken as a medical carrier for inhibiting and killing the atherosclerosis plaque cell.
Owner:HARBIN INST OF TECH

Liquid nitrogen skin treatment robot based on remote control

The invention relates to the field of robot technology, in particular to a liquid nitrogen skin treatment robot based on remote control. The robot comprises a wireless transmission device, a gyroscope, a monitoring system, a lighting device, a treatment arm portion, a moving portion and a remote end; the gyroscope can perform dynamic detection, the measurement accuracy is relatively high, and after the position information is adjusted, a second rotary table, a ball and a tooth movement mechanism arranged at the bottom of the robot base are used for moving the robot base to achieve the adjustment of a plane position; the intelligent processing system controls the pressure in a pressure tank, liquid medicine in the pressure tank is compressed to an injection head to complete the injection, in particular, there is a flow detecting device near the injection head, and the flow detecting device can be used for controlling the flow of the liquid medicine; the liquid nitrogen skin treatment robot can perform dynamic position detection and fixation, which improves the treatment accuracy; the robot can carry out wireless signal transmission, achieve remote control, and be more precise in theinjection of the liquid medicine, the whole process can achieve intelligent operation, and the robot is strong in creativity.
Owner:NANAN JIANJIN IND DESIGN

3D radiotherapy positioning film generating method and system, electronic device, and storage medium

The invention provides a 3D radiotherapy positioning film generating method. The 3D radiotherapy positioning film generating method comprises the steps that a three-dimensional patient model is created through patient body surface data; a region of a positioning film body on the three-dimensional patient model is selected, a positioning film body diagram is thickened according to the thickness ofthe positioning film body, and a three-dimensional positioning film body model is generated; and a three-dimensional positioning film fixing device model is acquired, and Boolean operation is performed on the three-dimensional positioning film body model and the three-dimensional positioning film fixing device model to generate a three-dimensional positioning film model. The invention relates to a3D radiotherapy positioning film generating system, and further relates to an electronic device and a readable storage medium for performing the 3D radiotherapy positioning film generating method. According to the 3D radiotherapy positioning film generating method, the three-dimensional patient model is created through the patient body surface data which are scanned by a 3D scanner or medical image data of a patient, 3D printing of the positioning film model is carried out by using environment-friendly materials, the positioning accuracy is high, the production time is short, and it is ensured that the patient is treated in the optimal treatment time so as to achieve precise radiotherapy.
Owner:GUANGDONG PUNENG BIOTECHNOLOGY CO LTD

Gamma ray therapeutic device

The invention discloses a gamma-rays therapeutic equipment, comprises the foundation fixed under the ground, above the function, the collimator foundation, framework foundation and CT engine base are assembled left-right. The framework can do 200 degree Centigrade axial rotary motion, the irradiation unit can make 200 degrees Centigrade B axial rotating motion. Both the rotating motion are superposed can result in the focal point of the radioactive source rays move on the most of the spherical surface., and realize ''dynamic focal point''. The treatment bed not only can lift fore-and-aft or upper-and-lower, to realize the cross-section or coronal section scan of patients, but also can move left-right, to realize the real-time detection change between gamma-rays treatment and roentgen rays. The real-time detection is good for patients to accomplish one time treatment. The synchronism can make position fixed check and treatment, eliminate the accumulated error of twice position fix, improve the therapeutic precision. This is the so-called ''check on-line''. Increasing the collimator data base, the collimators there changes with the collimators in irradiation unit automatically.
Owner:杭州威力克机电设备有限公司

High-precision combined type gamma knife collimator and machining method therefore

The invention discloses a high-precision combined type gamma knife collimator and a machining method thereof. The high-precision combined type gamma knife collimator comprises an upper positioning ring, a middle ring and a lower positioning ring. The middle ring is composed of multiple segmentation bodies. The multiple segmentation bodies are annularly combined and assembled to the annular middle ring. Each segmentation body of middle ring is provided with multiple collimator holes. The multiple collimator holes are annularly arranged in the middle ring. The upper positioning ring is installed on an upper opening of the middle ring. The lower positioning ring is installed on a lower opening of the middle ring. The middle ring is subjected to three-dimensional segmentation to form segmentation bodies, materials are selected according to the sizes of the segmentation bodies, the surface is roughly machined after heat treatment, fine machining is carried out after flaw detection, a base and the collimator holes are machined, and orderly assembly is carried out; surface rust-proof treatment is carried out after it is detected that the collimator is qualified, and the collimator is put in storage. By the adoption of the scheme of the segmentation bodies, the machining difficulty of the collimator body is lowered, the precision of the collimator parts and the collimator holes is greatly improved, the detection error of the product is reduced, and it is ensured that the requirement for focusing degree is met.
Owner:WUHAN RUIXIANGAN PRECISION MFG

Design method of tumor ablation treatment plan and tumor ablation scheme generation system

The invention relates to a design method of a tumor ablation treatment plan and a tumor ablation scheme generation system. The method comprises the following steps: carrying out data communication with a data server to obtain image information of a patient, carrying out imageology 3D reconstruction / fusion according to the image information, and drawing a patient tissue contour to obtain virtual patient information; forward designing an ablation treatment scheme according to the virtual patient information and treatment requirements; or reversely designing an ablation treatment scheme accordingto the virtual patient information of the patient and the treatment requirements input by the medical personnel; and outputting an ablation treatment scheme. Based on the biological effect identicalof a biological organism, the tumor ablation treatment scheme can be accurately generated, and a treatment plan can be generated for all tumor ablation equipment (including novel tumor ablation equipment). The method is simple, convenient, scientific and visual, medical personnel can be effectively guided, and the treatment accuracy of the tumor ablation equipment is improved.
Owner:刘珈

Laser engraving device

A laser engraving device which can adjust its machining position is disclosed. The device includes a laser machine for supplying laser beam, a guide rod adjacent to and parallel to the laser machine, a galvanometric scanner coupled to the guide rod and being movable with the guide rod, and a driver disposed at an end of the guide rod for driving the guide rod.
Owner:LEGEND LASER

Body position fixing apparatus and angle indicator

A body position fixing apparatus includes an indicating rod and a rotation mechanism that supports the indicating rod to make the indicating rod rotatable at a discretionary angle relative to each of the placement surface and a fixed reference plane including the first pressing surface, the second pressing surface, and the third pressing surface.
Owner:LEXI CO LTD

Household and hospital multiple-point strong-effect multiple-drug electrothermal moxibustion treatment dual-purpose device capable suitable for sitting and lying

InactiveCN102342886AImprove securityThere are many and reasonable moxibustion positionsDevices for heating/cooling reflex pointsTemperature controlMultiple point
The invention relates to a household and hospital multiple-point strong-effect multiple-drug electrothermal moxibustion treatment dual-purpose device suitable for sitting and lying, and is used for solving the problems that the existing moxa stick moxibustion appliance has poor comfort property, combustible moxa sticks generate smoke to pollute indoor environment, the operator labor intensity is high, the service efficiency is low and the like. The device is characterized in that: temperature-controlled electrothermal moxibustion devices, which are corresponding to traditional Chinese medicine channel and collateral points or organ reflecting regions or lymphoid tissue treatment points on human body and are used for holding moxibustion sheets or moxibustion bags, are arranged at the back, arm and seat board surface of a dual-purpose chair suitable for sitting and lying. The device has the advantages that: the moxibustion position are multiple, reasonable and comfortable; the moxibustion temperature is precisely adjustable; the device has strong safety and high treatment precision, and is suitable for comprehensive treatment; the moxibustion groove holes are arranged according to the human body moxibustion points or human body organ reflecting regions or lymphoid tissue treatment points; moxibustion can be carried out by patients without the assistance of professional; and the device can be conveniently used by households and various medical treatment and health-care institutions, and is very favorable for the popularization of moxibustion therapy.
Owner:李建书

Integrated intraoperative diagnosis and thermal therapy system

A multimodal medical device for the diagnosis and / or thermal treatment of a disease includes an instrument for performing thermal therapy; and an imaging system having multiple tomographic imaging modes, including optical coherence tomography (OCT), ultrasound imaging, photoacoustic (PA) imaging, fluorescence imaging and / or thermal imaging to provide guidance for accurate diagnosis and treatment of the disease.
Owner:SHANGHAI JIAOTONG UNIV +1

Magnetic stimulation device

The invention discloses a magnetic stimulation device, which is characterized in that the magnetic stimulation device comprises a deck chair and a magnetic therapy assembly, a main controller receivesan image transmitted by a scanning module, carries out three-dimensional modeling and defines simulation function partitions, then sets a test target point and carries out readjustment according to image information output by a monitoring module; the main controller sets a stimulation target point and a stimulation included angle according to the patient information received by the input unit; inthe magnetic therapy process, the main controller judges whether the real-time positions of the magnetic therapy hood and the head of the patient meet the set position or not, receives the pose stateinformation transmitted by the positioning tracker and judges whether the corresponding state of the stimulation coil and the stimulation target point meets the set state or not. According to the invention, the brain of an individual can be repositioned and adjusted in the magnetic therapy process, and then the pose relationship between the stimulation coil and the stimulation target point is tracked in the magnetic therapy process, so that the treatment precision of the whole magnetic therapy is improved, and a better magnetic therapy effect is achieved.
Owner:WENZHOU PEOPLES HOSPITAL

Shock wave therapeutic instrument

The present invention discloses a shock wave therapeutic instrument. The shock wave therapeutic instrument comprises a main engine, a movable arm and a shock wave source, the main engine is provided with a control end, the control end is connected with the shock wave source through an electric wire, a water inlet pipe is also connected between the main engine and the shock wave source, the shock wave source is arranged at an outer end of the movable arm, the movable arm is a two-section arm, and the shock wave source realizes three modes of movements of moving up and down, and left and right and rotating through linkage of the movable arm. An intelligent control module is arranged in the control end and stores parameter information so as to control frequency and intensity of shock waves generated by the shock wave source. An electromagnetic shock wave generating device is arranged in the shock wave source, a water bag is arranged at an output end of the shock wave source, and the waterbag contacts with an electromagnetic shock wave generating device to conduct the shock waves to act on a disease focus of a patient. The shock wave therapeutic instrument has remarkable advantages ofeasiness in mastering, safety, flexibility, convenience, light side effect, etc.
Owner:徐州康良电子科技有限公司

Interventional MR imaging with motion compensation

A method of magnetic resolution (MR) imaging of a moving portion of a body of a patient placed in an examination volume of a MR device. For the purpose of enabling improved interventional MR imaging from acquiring a MR signal data with motion compensation, the invention proposes that the method includes repeated acts of collecting tracking data from an interventional instrument introduced into the portion of the body, subjecting the portion of the body to an imaging sequence for acquiring one or more MR signals therefrom, wherein parameters of the imaging sequence are adjusted on the basis of the tracking data, and reconstructing one or more MR images from the MR signal data set.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV

Eyeball-motion-positioning-based proton-heavy ion beam current gate control method for eyeball tumor radiotherapy

The invention discloses an eyeball-motion-positioning-based proton-heavy ion beam current gate control method for eyeball tumor radiotherapy. The method comprises the steps: acquiring real-time images of an eyeball by utilizing eyeball motion image acquisition equipment, carrying out pixel graduation by utilizing a diameter of an iris, carrying out analysis so as to obtain a real-time motion displacement curve of the eyeball, setting a position deviation threshold, outputting a gate control signal to a proton-heavy ion treatment system through a communication unit, and then, controlling interruption and recovery of a proton-heavy ion beam current. According to the method, gate control on eyeball motion during proton-heavy ion radiotherapy of a malignant tumor of the eyeball is achieved, and the beam current of a proton-heavy ion device is interrupted when a deviation between an eyeball position and a reference position reaches a certain threshold; and the beam current is recovered when the deviation between the eyeball position and the reference position is smaller than the threshold, so that accurate radiotherapy of intraocular tumors is achieved, and the therapy efficiency is increased.
Owner:上海市质子重离子医院有限公司

Radiofrequency ablation probe without scales for cavity organs

The invention discloses a radiofrequency ablation probe without scales for cavity organs. The probe comprises a tube body, an energy applying device and a marking device, the energy applying device islocated at the front end of the tube body, and the marking device is installed on the tube body; the marking device further comprises a locating block, a marking block and a metering part connected between the locating block and the marking block, the marking block further comprises a soft elastic body and a hard clamping plate, and a second through hole for the tube body to penetrate through isformed in the soft elastic body; the hard clamping plate is installed in the second through hole through a rotary piece, and when the front end of the hard clamping plate makes extrusion contact withthe circumferential wall of the tube body, a gap is reserved between the back end of the hard clamping plate and the circumferential wall of the tube body. According to the radiofrequency ablation probe, it is avoided that printed marks enter the human body, so that the adverse influence on the human body is caused, the use safety of the radiofrequency ablation probe without the scales for the cavity organs is improved, the influence of the marking device on the treatment process can also be reduced, a worker conveniently controls the position of the marking block, and the moving precision ofthe marking block is effectively improved.
Owner:RESONANT MEDICAL TECH CO LTD

Non-isocentric rotary intensity-modulated radiotherapy device

The invention overcomes defects in the prior art, provides a non-isocentric rotary intensity-modulated radiotherapy device, the volume of equipment is reduced, the central dose rate and the clinical treatment efficiency are improved, and the risk of collision between a frame and a treatment bed (or a patient) is eliminated; in order to solve the technical problems, the technical scheme adopted isas follows: the non-isocentric rotary intensity-modulated radiotherapy device comprises a base, a roller, a treatment head frame and a treatment head, wherein the roller is movably arranged on the base and can make circular motion on the base in the own central axis; the treatment head frame is fixedly arranged on the inner wall of the roller, the treatment head is movably arranged on the treatment head frame through a rotating shaft, and the treatment head can rotate with the rotation shaft, so that the beam emitted by the treatment head does not always shoot to an isocenter; the non-isocentric rotary intensity-modulated radiotherapy device can be widely applied to the technical field of radiation therapy.
Owner:上海伽玛星科技发展有限公司

Real-time image guiding method

The invention discloses a real-time image guiding method, and relates to the technical field of real-time image guiding. The method comprises the steps: emitting a first ray to a detection plate through a ray generator of an X-ray image guiding system to obtain a first image, wherein the first ray is a kV-level X ray, and the pulse interval t of the first ray is greater than the imaging time of the detection plate; carrying out filtering and denoising on the first image to obtain a third image; acquiring a second image, wherein the second image is an image generated by the detection plate within the pulse interval t of the first ray; carrying out filtering and denoising on the second image to obtain a fourth image; and carrying out subtraction on the third image and the fourth image to obtain a fifth image. According to the real-time image guiding method, synchronous real-time X-ray image guiding can be realized in the radiotherapy process, the treatment accuracy is improved, the realization difficulty is low, and the cost is low.
Owner:江苏伽玛星医疗服务有限公司

Medical device for olfactory stimulation

The invention relates to a device for olfactory stimulation of a patient with a plurality of scents, said device comprising: —a source (2) of a carrier gas (G); —a plurality of scent odorization circuits, each odorization circuit (4) comprising: —a container (18) containing an odorous volatile substance (V), —a container inlet line (26), provided with a container inlet valve (28), connecting an inlet (30) of said container with said source of carrier gas, and —a container outlet line (36), provided with a container outlet valve (38), connecting an outlet (40) of said container with an exit line (12); —a control unit (8), configured to control said container inlet valve and container outlet valve according to a medical protocol.
Owner:INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM) +3
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