The invention discloses a sterilization composite containing pyraclostrobin and propineb and a preparation method and applications thereof. The sterilization composite is characterized by containing the pyraclostrobin, the propineb and other assistants, wherein the weight ratio of the pyraclostrobin to the propineb is (1:80)-(50:9). The sterilization composite can be applied to controlling the diseases of cereals, fruit trees, melons, vegetables and the like. The composite has a wide application range, low cost and a good effect. Proved by indoor efficacy trials, the composite has an obvious synergistic effect. Moreover, blending the pyraclostrobin with the propineb is not reported yet at home and abroad, therefore, the invention is disclosed.