31results about How to "Good clinical promotion value" patented technology

The present invention relates to a new use of a medicine for improving Dicer expression. The medicament is used in the preparation of medicaments for preventing and treating colitis or colon cancer. The colitis is selected from inflammatory bowel disease, which is ulcerative colitis and Crohn's disease, and the colon cancer is colitis-associated colon cancer. The drug that increases the expression of Dicer is selected from anastrozole, its salts, its metabolites, and its derivatives.

The invention discloses an ultramicro powder epimedium constant-temperature preparation method. The preparation method comprises the following steps of: taking the traditional Chinese medicine of epimedium, cleaning, and drying until the content of moisture is less than or equal to 10%; milling the epimedium under the room temperature to obtain coarse powder with the particle size of 60-80 meshes; placing the obtained coarse powder in a rod mill to be milled to enter a dedicated bidirectional air flow screening machine through the air to be subject to 500-mesh screening, obtaining powder with the particle size being less than or equal to 25 microns; and transmitting the powder into a cyclone collector through the air flow produced by a draught fan to obtain the finished product of the ultramicro powder epimedium, wherein the powder which is not subject to the 500-mesh screening is collected by a funnel, and is transmitted into the rod mill through a pipeline to be circulated and milled again. The invention has the advantages that the whole preparation process is carried out under the room temperature, no low temperature or special additional condition is needed, the prepared finished product of the ultramicro powder epimedium has the particle size being less than or equal to 25 microns, the cell wall-broken rate and the bioavailability are greatly improved, and the pharmacological effect of the medicine is strengthened. By the bidirectional air flow screening machine used in the invention, the preparation process of the ultramicro powder epimedium is simplified.

The invention relates to a mutation site examination of mitochondrial diseases MELAS and MERRF syndrome correlated mtDNA, disclosing a mutation site detection gene chip correlated with the syndrome mtDNA of the mitochondrial diseases MELAS and MERRF, wherein, a specific oligonucleotide probe is fixed on the surface lattice of the gene chip carrier and is used for detecting the mtDNA mutation sites correlated with mitochondrial diseases syndrome MELAS and MERRF. The invention also further discloses a preparation and application method of the gene chip. The gene chip of the invention can be used for detecting all mutation sites mtDNA concerned with the mitochondrial disease syndrome MELAS and MERRF with high sensibility and specificity and good repeatability; compared with the traditional molecular biological methods, the testing time is greatly shortened, and the purposes of clinical diagnosis and identification diagnosis of the MELAS and MERRF syndrome are realized.