Application of eight-component pill in preparation of medicine for preventing or treating cerebral ischemia and its complication

A technology for cerebral ischemia and complications, applied in the field of medicine, can solve the problems of cerebral ischemia and its complications without effective drugs, etc., and achieve the effects of significant clinical promotion value, alleviation of pain, and remarkable therapeutic effect.

Inactive Publication Date: 2015-05-20
孙喜翠
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the defect that there is no effective drug for the treatment of cerebral ischemia and its complications in the prior art, the purpose of the present invention is to disclose the use of Babao Dan in the preparation of drugs for the prevention or treatment of cerebral ischemia and its complications to solve the above problems

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0023] 1.3 Preparation of cerebral ischemia SD rat model

[0024] SD rats were fasted for 12 h and water deprived for 4 h before operation, anesthetized by intraperitoneal injection of 10% chloral hydrate (0.30 ml / 100 g), and fixed supine on a wooden operating table. The skin was prepared on the front of the neck, disinfected with alcohol and iodine, and the ventral neck was cut along the median, and the subcutaneous fat, sternohyoid muscle and sternocleidomastilla muscle were bluntly separated in sequence, and then the left and right common carotid arteries and The trachea was cut from the middle after double ligation at the proximal and distal ends, and then the muscles and skin were sutured layer by layer. The SD rats in the normal control group were incised in the same way, and the subcutaneous fat was separated.

[0025] 1.4 Determination of NO content and NOS activity

[0026] On the 10th week after modeling, the SD rats in each group were decapitated and their brains ...

Embodiment 3

[0064] Embodiment 3, the therapeutic effect of Babao Dan on the impaired memory function caused by cerebral ischemia:

[0065] 1 material

[0066] Babaodan adopts Babaodan capsules produced by Xiamen Traditional Chinese Medicine Factory (Guoyao Zhunzi Z10940006). The experimental animals used in this experiment are SD rats, and the dark avoidance automatic tester is a product of Chengdu Taimeng Technology Co., Ltd.

[0067] 2 Experimental methods

[0068] 2.1 Establishment of the experimental group: SD rats were randomly divided into the following treatment groups, 12 in each group. Each treatment group was given the following drugs:

[0069] Normal group: intragastric administration of the same volume of normal saline;

[0070] Model group: intragastric administration of the same volume of normal saline;

[0071] Babaodan group: give Babaodan capsules 50mg / (kg·d) by intragastric administration (according to the amount of Babaodan powder);

[0072] Babaodan group two: Bab...

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Abstract

The invention belongs to the field of medicines, and in particular relates to application of an eight-component pill in preparation of a medicine for preventing or treating cerebral ischemia and its complication. The complication of cerebral ischemia includes cerebral infarction or memory impairment caused by cerebral ischemia. The eight-component pill is mainly used for reducing peroxide content of nitric oxide and nitric oxide synthase in cerebral hippocampus and protecting nerve cell of cerebral hippocampus, so as to achieve the effect of treating cerebral ischemia; the MDA content in blood serum is decreased, and thus the damage of free radical to brain is reduced, the area of cerebral infarction is reduced, and as a result, the effect of treating cerebral infarction caused by cerebral ischemia is achieved; the pharmacological experiment shows that the eight-component pill has the effect of preventing memory impairment caused by cerebral ischemia. The eight-component pill has an obvious effect of preventing or treating cerebral ischemia, cerebral infarction or memory impairment caused by cerebral ischemia, is free of side effects, and has obvious clinical popularization value.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of Babaodan in the preparation of medicines for preventing or treating cerebral ischemia and its complications. Background technique [0002] Cerebral ischemia, medically known as stroke, is the interruption or reduction of blood flow in the arteries that supply the brain. Studies in recent years have shown that cerebral ischemia not only causes nerve cell necrosis. Delayed neuron death occurs at the same time, and delayed or selective cell death is mainly achieved through apoptosis, and the process of apoptosis can be activated by whole brain or partial cerebral infarction. Cerebral ischemia is a frequently-occurring disease that endangers human life and health, and has the characteristics of high morbidity, disability, mortality and recurrence. At present, the research on the mechanism of drugs for the treatment of cerebral ischemia mainly focuses on several import...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61P9/10A61P25/28A61P25/00A61K35/55A61K35/413A61K35/618A61K35/32A61K35/583
Inventor 孙喜翠
Owner 孙喜翠
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