The invention belongs to the technical field of hollow glass production, and discloses negative-pressure hollow glass, a manufacturing method and application. The negative-pressure hollow glass comprises glass, spacing bars, molecular sieves, supporting materials, sealing layers bonded between the glass and the spacing bars, and sealing layers bonded between the glass and the peripheries of the spacing bars. A hollow layer is vacuumized to be in a negative pressure state, the air pressure of the hollow layer is smaller than the external pressure all the time in the use process of the hollow glass, the breathing phenomenon of the hollow glass is eliminated, an edge sealing structure is not subjected to repeated acting force generated by the breathing phenomenon, and the service life of theedge sealing structure and the service life of the hollow glass can be remarkably prolonged; due to the fact that the supporting materials are arranged in the hollow layer, the glass cannot deform, agood mirror surface effect can be kept all the time, and the appearance of a building is more attractive; and the spacing bars are adopted to replace spacing frames to be directly bonded on the glass,the technological process of manufacturing the spacing frames is omitted, mechanical and automatic production is facilitated, the placement speed is high, and the installation precision is high.