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41 results about "Therapeutic Hormone" patented technology

Any synthetic or animal-derived agent that is chemically identical or similar to an endogenous hormone with therapeutic application.

Gastrin Releasing Peptide Compounds

InactiveUS20080008649A1Improve targetingDecreasing aberrant vascular permeabilityRadioactive preparation carriersGastrin releasing peptideCholic acidTherapeutic Hormone
New and improved compounds for use in diagnostic imaging or therapy having the formula M-N—O—P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N—O—P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and / or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided. Novel methods of treating prostate tumors or of delaying the progression of prostate tumors are also provided, including, methods of treating bone or soft tissue metastases of prostate cancer, methods for treating hormone sensitive and hormone refractory prostate cancer, methods for delaying the progression of hormone sensitive prostate cancer, for facilitating combination therapy in patients with hormone sensitive prostate cancer and for decreasing aberrant vascular permeability in patients with hormone sensitive prostate cancer.
Owner:BRACCO IMAGINIG SPA

17Beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitors for the Treatment of Hormone-Related Diseases

The invention relates to the use of non-steroidal 17beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment and prophylaxis of hormone-dependent, particularly estrogen-dependent, diseases. The invention further relates to suitable inhibitors and to a method for the production thereof.
Owner:UNIV DES SAARLANDES

Diarylhydantoin compounds

The present invention relates to diaryl hydantoin compounds, including diaryl thiohydantoins, as well as methods for their synthesis and use in the treatment of hormone-refractory prostate cancer.
Owner:RGT UNIV OF CALIFORNIA

Methods for treating hormone disorders

Method for screening for a non-hormone agent potentially useful to treat a hormone disorder The method involves contacting a potential agent with a system containing a cellular component and a translation factor. The component and factor interact with one another in an intact normal cell in a manner responsive to the hormone to cause a modulation of translation in the cell. The method involves determining whether the agent causes a modulation of translation by the component and the factor analogous to that which occurs in intact cells in response to the hormone.
Owner:QUESTCOR PHARMA

Methods for treating hormone associated conditions using a combination of LHRH antagonists and specific estrogen receptor modulators

Methods for treating hormone associated conditions, such as endometriosis, uterine leiomata, ovarian cancer, breast cancer, or vaginal bleeding, using LHRH antagonists and selective estrogen receptor modulators are disclosed. The methods include administering to a subject a combination of an LHRH antagonist and a selective estrogen receptor modulator. Pharmaceutical compositions and kits for use in the methods of the invention are also provided.
Owner:PRAECIS PHARM INC

Non-steroid antiandrogen compounds as well as preparation method and application thereof

The invention relates to the technical field of medicines and provides novel non-steroid antiandrogen compounds as well as pharmaceutically acceptable salts thereof, wherein the structural formula of the compounds is as shown in formula (I). The invention further provides a preparation method of the compounds and application of the compounds in preparation of antiandrogen compounds and drugs for treating steriod-resistant prostatic cancer.
Owner:沈江 +2

Composition comprising progesterone-receptor antagonists and pure antiestrogens for prophylaxis and treatment of hormone-dependent diseases

InactiveUS20050014736A1Effective treatmentEffectively inhibit the growth of such tumorsOrganic active ingredientsAntineoplastic agentsProgestin AntagonistTherapeutic Hormone
The present invention relates to methods and uses for preventing or treating hormone-dependent diseases, in particular breast cancer, in a mammal, by a combination of an progesterone-receptor antagonist, in particular the progesterone-receptor antagonist 11β-(4-acetylphenyl)-17β-hydroxy-17α-(1,1,2,2,2-pentafluoroethyl)-estra-4,9-dien-3-one or a pharmaceutically acceptable derivative or analogue thereof, and a pure antiestrogen, in particular a compound of general formula I as defined in the specification, for instance 11β-Fluoro-17α-methyl-7α-{5-[methyl(8,8,9,9,9-pentafluorononyl)amino]pentyl}-estra-1,3,5(10)-triene-3,17β-diol. The invention further relates to pharmaceutical compositions comprising said combination.
Owner:BAYER SCHERING PHARMA AG

Sepia pharaonis neuropeptide GnRH and use thereof

InactiveCN106589070APrevent loss of activity due to dehydrationAvoid degradationNervous disorderPeptide/protein ingredientsSepia pharaonisDisease
The invention provides Sepia pharaonis neuropeptide GnRH and a use thereof. A preparation method of the Sepia pharaonis neuropeptide GnRH comprises 1) pretreatment: taking a living Sepia pharaonis, dissecting to take the brain tissue and storing the brain tissue in a preservation liquid at an ultralow temperature of -70 to -90 DEG C, 2) supernatant collection: taking the brain tissue, adding the equal volume of normal saline into the brain tissue, carrying out homogenization and centrifugation, taking the supernatant A, then adding the equal volume of distilled water into the supernatant A, carrying out centrifugation, taking the supernatant B, and merging the supernatants A and B to obtain a supernatant C, and 3) column chromatography: carrying out column chromatography on the supernatant C, carrying out color development, collecting components and carrying out freeze drying. The preparation method can realize cryopreservation of the tissue, realizes excellent effects, and can effectively prevent the degradation of the Sepia pharaonis brain tissue. The extract can be used in drugs for prevention or treatment on hormone-dependent diseases.
Owner:ZHEJIANG OCEAN UNIV

Kit for screening steroid-induced necrosis of femoral head

The invention discloses a kit for screening the steroid-induced necrosis of the femoral head. A molecular marker for screening the steroid-induced necrosis of the femoral head in the early period is proposed, and miR-100 expresses up-regulation in a sample of the steroid-induced necrosis of the femoral head; application of miR-100 in preparation of the kit for screening the steroid-induced necrosis of the femoral head and application of miR-100 in candidate medicine for screening or preventing or treating the steroid-induced necrosis of the femoral head are further provided. It is discovered that miR-100 is high in specificity and sensitivity, can be effectively applied to early detection of the steroid-induced necrosis of the femoral head and can be applied to clinical application of genetreatment, medicine treatment and the like.
Owner:PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI

Steroidal antiestrogens and antiandrogens and uses thereof

The present invention comprises the design, synthesis and development of a new class of chemotherapeutic agents for prophylactic and therapeutic treatments in a mammal, particularly a human, believed to be at risk of suffering from a hormone-responsive disorder. In an aspect of the invention, such treatments include therapeutic compositions comprising novel steroidal antiestrogen and antiandrogen compounds. In a preferred aspect, such a novel compound of the present invention has an address and a message component, which are made into a single composite entity for more aggressive intervention and effective treatment of hormone-responsive disorders, thereby prolonging the disease-free interval for the patient and reducing a number of side effects.
Owner:NORTHEASTERN UNIV

Medicine for treating corticosteroid-dependent dermatitis and preparation method thereof

The invention provides a pharmaceutical composition for treating corticosteroid-dependent dermatitis and a preparation method thereof. The pharmaceutical composition comprises, by weight, 4-6 parts of white mulberry root bark, 2-4 parts of fritillaria cirrhosa, 2-4 parts of angelica sinensis, 2-4 parts of fructus kochiae, 4-6 parts of radix sophorae flavescentis, 2-4 parts of fleece-flower root, 0.5-1.5 parts of chrysanthemum, 0.5-1.5 parts of honeysuckle, 0.5-1.5 parts of pseudo-ginseng flower, 2-4 parts of motherwort, 0.5-1.5 parts of ganoderma lucidum and 0.5-1.5 parts of wild ginseng. The pharmaceutical composition has the advantages that the pharmaceutical composition has effects of clearing away heat and toxic materials, activating blood and relieving swelling, purging fire for removing toxic materials and activating blood circulation to dissipate stasis and can be effectively used for treating the corticosteroid-dependent dermatitis.
Owner:乔浩

Uses of Erss Modulators

The present invention relates to uses of ERβ modulators in the preparation of medicaments for preventing and / or treating hormone dependant cancers and other proliferative disorders, as well as diagnosis of hormone dependant cancers and other proliferative disorders. The present invention also teaches a method of screening agents for their use in preventing and / or treating hormone dependant cancers and other proliferative disorders.
Owner:THE UNIV OF EDINBURGH

Method and apparatus for measurement of the effect of test compounds on signal transduction at the level of biological receptors

A method and apparatus for measuring binding between a plurality of molecules of a biological receptor protein and a plurality of molecules of a type which binds to said biological receptor is presented. Apparatus utilizes a sensor possessing a waveguide to which have been attached in close proximity to its surface, features resembling molecules having binding affinity for said biological receptor. Light is injected into said waveguide so as to produce an evanescent field at its surface. Molecules of receptor protein are tagged with a tag belonging to that class of chemicals which alters a characteristic of light, when said light passes through said chemical tag. Apparatus utilizes a rapid means of monitoring the change in optical signal coming from the waveguide as binding proceeds between tagged receptor protein and the binding molecular feature of the waveguide. This allows direct measurement of binding and dissociation rates between the receptor and the binding feature of the waveguide. By using a waveguide having a feature resembling a ligand for the receptor, the potential hormonal activity of a test substance may be evaluated from its ability to compete with the waveguide for binding with the receptor. The effect of a test compound on binding of receptor protein to a subsequent element in a hormonal signal transduction mechanism is evaluated by measuring the impact of the test compound on binding between receptor protein and a feature resembling said next element of the signal transduction mechanism. Methods are provided whereby such data may be used to compute affinity constants, binding activity, complex affinity constants resulting from cooperativity, and kinetic parameters for the receptor and test ligand and for the receptor and the next element of the signal transduction mechanism. Preferred embodiments of the invention illustrate application of the method and apparatus to measuring binding between biological receptors and their nuclear response elements, and the use of this type of measurement for assessment of the activity of estrogen mimics present in a test sample, and for evaluation of pharmaceuticals intended to treat hormone dependent cancers.
Owner:IA +1

Anti-Aging Therapy for Canines and Other Domesticated Animals

PendingUS20210228502A1Toxic build-upWiden the optionsHydroxy compound active ingredientsAccessory food factorsHormone precursorProhormone
The present invention discloses a system and method for preparing and delivering various precursor compositions as a replacement therapy for testosterone and other hormone deficiencies that naturally occur with aging in canines and other domesticated animals. Precursor compositions are selected and designed for the purpose of formulating non-toxic therapeutic hormone supplement for oral consumption. The invention features low dose continuous supplementation to be incorporated with daily meals. The process of the present invention delivers an orally ingested substance, e.g., a food, supplement, treat, etc., that contains an anti-aging formulation comprising a hormone precursor (prohormone) that is absorbed by the digestive system and secreted into the bloodstream with a second substance to facitate its ingestion, absorption and delivery to the body's tissues.
Owner:REVIGORON LLC

Application of lipid active substance of theaceous plant in treating hormone-dependent dermatitis

The invention relates to application of a lipid active substance of a theaceous plant in treating hormone-dependent dermatitis. A treatment method is to prepare the lipid active substance into an acceptable dosage form, an intestinal administration or local administration mode is adopted, and the lipid active substance has the efficacies of clearing heat and releasing toxin, dispelling wind and eliminating dampness, nourishing yin and cooling blood; the lipid active substance is locally smeared at least twice every day in external use, and the smearing amount is determined according to the skin area and the skin absorption condition; and the lipid active substance has the functions of backing red, dispersing swelling and relieving ache and itch, is also favorable for wound surface epithelial cell formation, granulation tissue growth and wound surface healing, can be used for preparing a product for preventing and treating the hormone-dependent dermatitis, provides a brand-new treatment scheme with exact treatment effect for patients, and also can make full use of natural resources and improve the human health-care level and the quality of life.
Owner:江西金海棠药用油有限公司

Moisturizing cream suitable for atopic dermatitis of children

ActiveCN113350262ASignificant effectEfficacy adjustmentCosmetic preparationsToilet preparationsChildhood atopic dermatitisTherapeutic Hormone
The invention provides a moisturizing cream suitable for atopic dermatitis of children. According to the moisturizing cream, a lactobacillus fermentation product is applied to skin moisturizing cosmetics for adjuvant treatment of children atopic dermatitis for the first time, and then allantoin, an oat extract, ceramide, phytosterol, fatty acid, glycyrrhizic acid, glycyrrhizate, hesperidin, grease and a moisturizer are used as auxiliary materials; and the moisturizing cream prepared by the invention has a remarkable curative effect on atopic dermatitis, can regulate the skin micro-ecological environment and improve the phenomena of severe skin itching, dry skin and the like, improves the safety under the condition of ensuring the curative effect of the medicine on the atopic dermatitis, and does not irritate the skin of children. The moisturizing cream disclosed by the invention can be used for assisting in treating the atopic dermatitis of children, the dosage of treatment hormone is reduced, and the stimulation caused by the treatment hormone is effectively relieved.
Owner:绽妍生物科技有限公司

Composition for treating hormone face and acne skin and preparation method thereof

The invention belongs to the technical field of biology and new medicine, and particularly relates to a composition for treating hormone face and acne skin, the composition comprises the following active ingredients: hyaluronic acid, glycerol, vitamin B, trehalose and stem cell culture supernatant, and the stem cell culture supernatant is derived from human umbilical cord mesenchymal stem cells. The preparation method of the composition comprises the following steps: (1) calculating and weighing the hyaluronic acid, the glycerol, the vitamin B, the trehalose and the stem cell culture supernatant according to the mass percentage contents of 1 to 3%, 2 to 6%, 0.1 to 2%, 2 to 20% and 20 to 30% respectively, and supplementing the balance of sterilized water for injection to 100%; and (2) fully mixing the components, and aseptically filling the mixture into a 2ml sterile heat-source-free pipe. The invention has the beneficial effects that the product takes effect for a short time, can treat various skin problems, and is high in effective rate and not easy to relapse.
Owner:奥瑞京生物科技(北京)有限公司

Application of lipoxin in treating hormone-dependent type asthma

The invention discloses application of lipoxin in treating hormone-dependent type asthma. Glucocorticoids become preferred drugs for asthma treatment and play important roles in controlling the asthma, but hormone-dependent type asthma patients are necessary to use the glucocorticoids in quantity for a long time so that intracorporal glucocorticoid receptors are down regulated and reduced in affinity, therefore the inhibition of the airway inflammation is affected and the asthma is recurrent and protractedly cured. The lipoxin can enhance the sensibility of the hormone-dependent type asthma patients on hormones by inhibiting related multidrug resisting proteins, thereby enhancing the curative effect on treating the asthma through the hormones and reducing the dosage and the side effect of the hormones; and in addition, the invention provides a new treatment method for the hormone-dependent type asthma.
Owner:HUAZHONG UNIV OF SCI & TECH

Traditional Chinese medicine preparation for treating hormone-dependent dermatitis and preparation method of traditional Chinese medicine preparation

The invention provides a traditional Chinese medicine preparation for treating hormone-dependent dermatitis and a preparation method of the traditional Chinese medicine preparation. The preparation method comprises the following steps: crushing natural Chinese herbal medicines, and respectively extracting the crushed natural Chinese herbal medicines for three times by using cold water which is 5 times, 7 times and 10 times of the dry weight of the medicines to obtain first extract liquor and first filter residues; extracting the first filter residues for three times by using hot water which is2 times, 4 times and 6 times of the dry weight of the medicines to obtain second extract liquor; respectively filtering the first extract liquor and the second extract liquor by using a filter element with the aperture of 0.5-1 microns to obtain first filtrate and second filtrate, and merging the first filtrate and the second filtrate; performing centrifugal treatment on the filtrate, and reserving supernate; and concentrating the supernate at low temperature, and preparing the concentrate into powder to obtain the traditional Chinese medicine preparation. The preparation method of the traditional Chinese medicine preparation for treating the hormone-dependent dermatitis is high in extraction efficiency, and the relative content of the extracted effective components is high. Moreover, various operations are conventional, no technical operation threshold exists, and the traditional Chinese medicine preparation for treating the hormone-dependent dermatitis and the preparation method ofthe traditional Chinese medicine preparation are suitable for popularization and industrialization.
Owner:北京赵桂荣中医药科技有限公司

Analysis method of hyssopus officinalis volatile oil and application of hyssopus officinalis volatile oil in preparation of medicine for treating hormone-resistant asthma

The invention relates to an analysis method of hyssopus officinalis volatile oil and application of the hyssopus officinalis volatile oil in preparation of a medicine for treating hormone-resistant asthma, which comprises qualitative and relative quantitative analysis of chemical components of the hyssopus officinalis volatile oil, construction of a hormone-resistant asthma model and grouped administration. The influence of the hyssopus officinalis volatile oil on the number of inflammatory cells in alveolar lavage fluid and peripheral blood of a mouse with the hormone-resistant asthma is researched, and the influence of the hyssopus officinalis volatile oil on the concentration of interleukin-17 (IL-17) and granulocyte colony stimulating factor (G-CSF) in BALF and lung tissues of the mouse with the hormone-resistant asthma is researched. The influence of the hyssopus officinalis volatile oil on pathological changes of lung tissues of mice with hormone-resistant asthma is studied, and the chemical components of the hyssopus officinalis volatile oil and the pharmacological action of the hyssopus officinalis volatile oil for treating the hormone-resistant asthma are integrally evaluated according to the studies. The hyssopus officinalis volatile oil has great significance in new drug research and clinical application of the hyssopus officinalis volatile oil for treating the hormone-resistant asthma.
Owner:HUAZHONG UNIV OF SCI & TECH

External medicine for treating hormone-dependent dermatitis and preparation method thereof

The invention provides an external medicine for treating hormone-dependent dermatitis and a preparation method thereof, and the preparation method comprises the following steps: dissolving extracted medicines and functional ingredients in water to obtain a medicine aqueous solution; adjusting a medicine aqueous solution to be weakly acidic to obtain a medicine stock solution; concentrating the medicine stock solution to 1.1-1.3 g / mL under the protection of low-temperature inert gas to obtain a medicine concentrated solution; and diluting the medicine concentrated solution with water to 20 times the volume of the medicine concentrated solution to obtain the external medicine for treating hormone-dependent dermatitis. According to the preparation method of the external medicine for treatinghormone-dependent dermatitis, the abundance of effective active ingredients is higher and more stable, meanwhile, the external medicine has a reasonable pH value and is milder, and the skin of a patient suffering from hormone-dependent dermatitis which is sensitive to the external medicine is prevented from being further stimulated. The user experience is better.
Owner:北京赵桂荣中医药科技有限公司

Topical compositions

The present disclosure provides a novel topical composition comprising at least one active agent and method for making the composition. Certain compounds have been combined to make a stable composition comprising at least one active agent such as selective estrogen receptor modulators and aromatase inhibitors. The present disclosure also provides methods for treatment of hormone-dependent breast and hormone-dependent reproductive tract disorders.
Owner:ATOSSA THERAPEUTICS INC

A kind of traditional Chinese medicine for treating steroid-induced necrosis of the femoral head and its application

The invention relates to a traditional Chinese medicine for treating steroid-induced necrosis of the femoral head and its application. ‑18 parts, Chuanxiong 15‑20 parts, coix seed 10‑12 parts. The traditional Chinese medicine formula for the treatment of steroid-induced femoral head necrosis provided by the invention exerts a more significant effect through the interaction between the medicines and promotes each other, so that the Qi and blood can be unblocked, the liver and kidney can be nourished, and the kidney yang can be strengthened, the bones and muscles can be strengthened, and the blood can be circulated. It can treat both symptoms and root causes of steroid-induced necrosis of the femoral head, and the curative effect is remarkable.
Owner:THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV OF TCM

A traditional Chinese medicine compound external preparation for treating hormone-dependent dermatitis and its preparation method and application

The invention provides a traditional Chinese herbal compound external preparation for treating hormone dependent dermatitis. An effective part is prepared by the following Chinese herbal medicines according to the parts by weight: 5-80 parts of rhizoma polygonati, 5-60 parts of flos lonicerae, 5-60 parts of flos chrysanthemi, 5-60 parts of poria cocos and 3-60 parts of liquorice. The invention further discloses a preparation method and an application of the preparation. The preparation is capable of mainly using the rhizoma polygonati as a monarch drug, using the flos lonicerae and the flos chrysanthemi as ministerial drugs together, using the poria cocos as an adjuvant, and using the liquorice as a conductant drug for reconciling the drug properties of a whole prescription, using the effects of nourishing Yin and moistening dryness, removing pathogenic heat from blood and toxic material from body, clearing away heat and removing dampness, and dispelling wind and arresting itching as abasic treatment rule of the preparation, and promoting the repair of the hormone dependent dermatitis. The prescription is simple, accords with a traditional Chinese medicine theory of treating the hormone dependent dermatitis, and has the support and evidence of modern pharmacology achievements of each single Chinese herb. An extracting process for the compound effective part is simple, the effective ingredient content is high, the introduction of non-effective ingredients is reduced, a preparation technology is scientific, a transmittance rate of the effective ingredients in a pathologicaltissue is high, the animal experiment and human body trial effect is remarkable without the adverse reaction, the use is convenient and the adaptability is good.
Owner:王文萱
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