32 results about "Small intestinal motility" patented technology

The invention discloses compound functional sugar with a function of adjusting intestinal flora. The compound functional sugar contains functional oligosaccharide, L-arabinose, dietary fiber and probiotics and is characterized in that bifidobacterium, lactobacillus and other beneficial bacteria can be proliferated; meanwhile, the proliferation of escherichia coli, enterococcus and other harmful bacteria is restrained to adjust the intestinal flora; and the small intestine peristalsis can be promoted, the defecating time can be shortened, the defecation quantity can be increased to play a role in defaecation.

The invention discloses bifidobacterium bifidum capable of remarkably relieving constipation and application thereof and belongs to the technical field of microorganisms. The bifidobacterium bifidum CGMCC NO.13632 can well tolerate simulative gastrointestinal fluid, can be well attached to colon cancer cells HT-29, and can remarkably increase the water content of excrement of constipation mice and shorten the first tarry stool time. On the aspect of increasing the small intestine driving rate, the bifidobacterium bifidum CGMCC NO.13632 is superior to cathartic phenolphthalein, a best effect is shown, secretion of gastrointestinal regulatory peptide relevant to constipation in serum is also adjusted while constipation pathological factors are remarkably improved, and the bifidobacterium bifidum does not have toxic and side effects of medicine for treating constipation, and is a first choice for preventing and treating constipation. The bifidobacterium bifidum CGMCC NO.13632 is used for preparing pharmaceutical compositions and fermented food for relieving constipation, and has very wide application prospects.

The invention discloses a lactobacillus fermentum Lee working fermenting agent product and application thereof to prevent constipation and keep healthy. Lactobacillus fermentum Lee is preserved in China Center for Type Culture Collection with the preservation number of CCTCCM2013512. Lactobacillus fermentum Lee is capable of normally growing in human intestinal tracts. Mouse in-vivo tests show that lactobacillus fermentum Lee is capable of alleviating the mouse body weight mitigating trend caused by constipation, accelerating melaena discharging time, improving intestinal propulsive rate, increasing levels of MTL, Gas, ET, AchE, SP and VIP in serum to different degrees, reducing SS factor level, increasing food intake and water intake, and reducing the decrease trend of defecation amount, defecation particle quantity and water content in faeces, gives play to effects similar to that of constipation-treating medicines, and shows certain constipation prevention effect. The optimum usage dosage is 1.0*10<9> CFU for per kg body weight.

The invention discloses Lactobacillus fermentum suo for adjusting intestinal tract motion and preventing constipation and a use thereof. The Lactobacillus fermentum suo has a preservation number of CCTCC NO: M2013511, has strong acid resistance, has a survival rate of 92.46+ / -4.06% after being arranged in an artificial gastric juice with a pH value of 3.0 for 3h, can slowly grow in cholate with a concentration of 1.0%, has a growth rate 17.36+ / -1.19% that of cholate-free culture, has cell hydrophobicity of 68.44+ / -2.48% and can normally grow in the human intestinal tract. Lactobacillus fermentum suo can relieve constipation-caused mouse weight reduction, reduce tarry stool excretion time, improve a small intestine propulsion rate, improve serum MTL, Gas, ET, AchE, SP and VIP factor levels to different degrees, reduce a SS factor, improve food intake and water intake, relieve reduction of a stool excretion mount, the number of stool particles and stool water content and can produce a certain constipation prevention effect similar to those of constipation treatment drugs.

The invention discloses bifidobacterium bifidum for relieving constipation as well as a fermented food and a probiotic preparation prepared from the bifidobacterium bifidum, and belongs to the technical field of microorganisms. The Bifidobacterium bifidum CCFM1167 provided by the invention can be used for effectively relieving the first black stool time, the intestinal tract propulsion rate and the water content of stool of a mouse with constipation, and has the effect of obviously improving the apparent pathological indexes of constipation; in the detection of physicochemical indexes, the bifidobacterium bifidum can also influence the content of gastrointestinal active peptides, so that the intestinal peristalsis is influenced; the bifidobacterium bifidum also can effectively relieve pathological injury of colon tissues so as to effectively relieve constipation symptoms, and compared with bifidobacterium longum GDMCC NO: 60941, the bifidobacterium bifidum has more obvious influence on MTL content, further has more obvious effect on increasing the small intestine propulsion rate, and is more suitable for constipation patients with weak small intestine propulsion.

The invention relates to the field of medical biotechnology, and in particular relates to an application of a Uighur medicine compound Muniziqi extract in preparation of a small intestinal peristalsis promoting medicine. The Uighur medicine compound Muniziqi extract is prepared by a preparation method as follows: step 1, mixing fennel root and bark, peganum harmala, pimpinella anisum, chamomile, celery root, witloof seed, fennelflower seed, chicory root, citronella, moldavica dragonhead herb seed, liquorice, basil fruit and hollyhock seed together to obtain a mixing medicinal material; and step 2, extracting and decocting the mixing medicinal material in water for three times. The Uighur medicine compound Muniziqi extract is comparatively good in effects of promoting small intestinal peristalsis and promoting defecation and hardly has toxic or side effects; when used for treating gynecological diseases, skin diseases and other diseases, the Uighur medicine has relatively good effect of promoting small intestinal peristalsis, so as to further accelerate metabolism and enhance vivotoxin elimination of patients; the Uighur medicine can reduce the economic burden of the patient and the hurt to the patients, has good application prospect, and is proposed for the first one at home and abroad at the present time.

The invention discloses a bifidobacterium bifidum for relieving constipation and regulating intestinal flora disorder and application thereof, and belongs to the field of microorganisms. The bifidobacterium bifidum provided by the invention can obviously improve the water content of excrement and the intestinal propulsive rate and reduce the first black excrement time of constipation mice, and has the effect of obviously improving apparent pathological indexes of constipation; in the detection of physiological indexes, the bifidobacterium bifidum can also improve the content of motilin and reduce the content of somatostatin, so that the intestinal tract movement is fundamentally influenced; the bifidobacterium bifidum can regulate the abundance of important microorganisms in the intestinal tract and maintain the steady state of the intestinal tract. Compared with GDMCC NO: 60940, the bifidobacterium bifidum CCFM1166 has the advantages that the content of MTL in serum is better increased, the content of SS in the serum is reduced, and the promotion effect on intestinal peristalsis is more remarkable, so that a more personalized treatment scheme can be adopted for constipation patients in the future, and the application prospect is very considerable.

The invention discloses a plant wine or drink prompting digestion, and particularly relates to a large-fruited Chinese hawthorn appetizer wine or drink and a preparation method thereof. The large-fruited Chinese hawthorn appetizer wine or drink is prepared from Chinese hawthorn fruits, fried malt, pericarpium citri reticulatae, fried radish seeds, fennel, fructus citrus sarcodactylis, fructus hippophae, liquorice roots, cassia bark, xylooligosaccharide, potassium sorbate, and baijiu with the alcohol content of 38% or grape wine or water. The composition has the obvious effect of increasing the total gastric juice amount, the gastric juice discharge amount and the pepsase discharge amount and the obvious effect of increasing the small intestine propulsion speed of a mouse slow gastrointestinal motility model, which shows that the composition has the effects of promoting digestion and promoting gastrointestinal motility. The large-fruited Chinese hawthorn appetizer wine or drink has the advantages of being safe, effective, free of side effects and the like. The modern advanced ultrasonic extraction technology is adopted for preparing the large-fruited Chinese hawthorn appetizer wine or drink, so that the utilization rate of effective constituents of plants is significantly increased, and energy conservation and environment protection are achieved; radish seeds are subjected to quantitative microwave frying, and the large-fruited Chinese hawthorn appetizer wine or drink is suitable for industrial production, is novel and can fill up the blank of appetizer wine in China.

The invention discloses a health care product with a function of relaxing bowels and a preparation method thereof. The health care product is prepared from the following raw materials in parts by weight: 100-300 parts of Chinese angelica, 200-600 parts of milkvetch roots, 150-450 parts of largehead atractylodes rhizomes, 150-450 parts of plantago ovata seed shell, 250-750 parts of fructus cannabis, 100-300 parts of cassia seeds and the like. According to the theory of traditional Chinese medicines and the pathogenesis of constipation, the raw materials are selected for compound and compatibility. Particularly, plantago ovata seed shell powder is added to be mixed with the traditional Chinese medicines according to a specific proportion, so that a synergistic effect can be exerted, and theproportion of the components is scientific and reasonable. Experimental results show that the health-care product provided by the invention has effects of promoting small intestine propulsion and emptying movement, can promote gastrointestinal motility and has a good defecation promoting effect.

The invention discloses a traditional Chinese medicine compound composition for treating refractory gastroesophageal reflux. The traditional Chinese medicine compound composition is prepared from the following components in parts by weight: 10-20 parts of inula flower, 10-20 parts of processed rhizoma pinelliae, 10-20 parts of processed rhizoma cyperi, 4-14 parts of caulis perllae, 10-20 parts of raw folium eriobotryae, 10-20 parts of pericarpium citri reticulatae, 10-20 parts of poria cocos, 20-40 parts of cuttlebone and 20-40 parts of fried semen raphani. The traditional Chinese medicine compound composition for treating refractory gastroesophageal reflux provided by the invention has an anti-inflammatory effect, can improve the gastric emptying rate of rabbits, improve the small intestine peristalsis of the rabbits and improve the small intestine propulsion rate, can reduce the expression of inflammatory factors in gastric tissues, has no adverse reaction and no obvious toxic or side effect, and is safe and effective.

The invention belongs to the technical field of construction and evaluation methods for experimental animal models, and particularly relates to a construction and evaluation method for an experimentalanimal model of depression with gastrointestinal motility disorder. A CUMS (chronic unpredictable mild stress) model can be used to simulate the depression, intraperitoneal injection of L-arginine can simulate the gastrointestinal motility disorder, and through combination of the two, the experimental animal model of the depression with the gastrointestinal motility disorder is obtained. A behavioral test is an effective detection indicator for evaluating the depression, and the gastric emptying rate and the small intestinal advancing rate are effective indicators for evaluating the gastrointestinal motility disorder. Obtained behavioral data and gastrointestinal motility disorder detection indicator data are processed through statistical inspection, experimental animals have differencesbefore and after modeling, the differences reflect, to a certain degree, whether construction of the experimental animal model is successful or not, and accordingly, the experimental animal model forresearch on the depression with the gastrointestinal motility disorder is evaluated in a targeted way. It can be seen from comparison that the evaluation method can more fully reflect the performancecharacteristics of clinical diseases.

The invention provides a medicine for quickly treating anorexia of infants. The medicine is prepared by the following Chinese herbal medicines: endothelium corneum gigeriae galli, scorpio, wrinkled gianthyssop herbs, fructus amomi, spina gleditsiae, clove, smoked plums, tuckahoes, piper cubeba, rhizoma atractylodis, mint, lily, radix glehniae, fructus aurantii, hyacinth beans, radix polygonati officinalis, radix trichosanthis, howthorn, malt, elecampane, galangal and rhizoma picrorhizae. The medicine has an excellent treatment effect on infant anorexia caused by various reasons, and pharmaceutical formulation does not have toxic or side effects. The medicine has effects of nourishing the stomach and the spleen and moving qi to remove food retention, small intestine peristalsis can be promoted effectively, the absorption function of small intestines of the infants is improved, the immunologic function of body cells is improved, the appetite of the infants is improved effectively, and the food intake of the infants can reach that of normal healthful infants.

The invention provides a novel use of a cathartic formula with five fruits and vegetables as raw materials, and especially use of a cathartic formula with five fruits and vegetables as raw materials in preparation of foods or medicines for increasing gastrointestinal peristalsis and promoting gastrointestinal emptying. The cathartic formula is "Baitong" Tiantian Capsule composed of pumpkin, aloe,poria cocos, tremella fucifamis and xylooligosaccharide with a fineness of 5-20 mum. Studies show that the "Baitong" Tiantian Capsule can accelerate gastrointestinal transmission, increase gastrointestinal peristalsis, and promote gastrointestinal emptying, and increase gastric emptying rate and small intestinal propulsion rate in FD rats in a dose-dependent manner, provides a new method for enhancing gastric peristalsis and promoting gastrointestinal emptying, and has broad clinical application prospects.

The invention relates to applications of 2-phenylamino-4-pyrrolidyl-6-(5-(4-methyl-1-piperazinyl)-2-pyridyl)aminopyridino-[3,4-d]pyrimidine in preparation of medicines for promoting small intestine peristalsis. The pharmacological experiment shows that 2-phenylamino-4-pyrrolidyl-6-(5-(4-methyl-1-piperazinyl)-2-pyridyl)aminopyridino-[3,4-d]pyrimidine has a relatively good effect of promoting smallintestine peristalsis, has the outstanding substantive characteristics, and obviously has remarkable progress in preparation of the medicines for promoting small intestine peristalsis.

The invention discloses Lactobacillus paracasei CCFM1069 and its application. Lactobacillus paracasei CCFM1069 can tolerate the gastrointestinal environment of human body, significantly improve the water content of feces, improve the propulsion rate of small intestine, shorten the time for the first black stool, and down-regulate casein in serum. Tyrosin content, up-regulation of serotonin level in colon tissue, up-regulation of neurotrophic factor 3 level in colon tissue, down-regulation of Aqp4 gene transcription level in colon tissue, increase of the number of interstitial cells of Cajal in colon tissue and increase of short-chain fatty acid content in intestine content; the Lactobacillus paracasei CCFM1069 has a strong adsorption capacity for perfluorooctanoic acid, has the ability to alleviate the toxicity of PFOA, and has a very wide application prospect.

The invention provides a traditional Chinese medicine composition for treating infantile dyspepsia and phlegm-heat cough and a preparation method thereof. The traditional Chinese medicine compositionis prepared from hawthorn, pinellia ternate, pericarpium citri reticulatae, platycodon grandiflorum, trichosanthes kirilowii maxim, immature bitter orange, mangnolia officinalis, scutellaria baicalensis, fructus forsythiae, semen raphani, semen lepidii, burdock, fructus arctii, the root bark of white mulberry and folium eriobotryae. Pharmacodynamic and clinical tests show that the traditional Chinese medicine composition can increase the content of motilin and promote small intestine propulsion, can achieve the effects of clearing heat and regulating the lung, helping digestion and relieving stasis, preventing phlegm from forming and stopping coughing and treating both symptoms and root causes for patients suffering from infantile dyspepsia and phlegm-heat cough, and is convenient to use,safe and effective.

The invention provides an application of asperulosidic acid or a pharmaceutically acceptable salt thereof in preparation of a medicine for promoting gastrointestinal peristalsis. The medicine is a common preparation prepared from the asperulosidic acid or the pharmaceutically acceptable salt thereof as an active ingredient by adding pharmaceutically acceptable auxiliary materials or auxiliary ingredients. Spectral effect analysis of paederia scandens shows that the asperulosidic acid can improve the gastric emptying rate and the small intestine propulsion rate, and the clinical prospect is excellent.

The invention relates to the technical field of medicines, in particular to application of Gensci073 or analogues thereof. The invention provides the application of Gensci073 or analogues thereof, andparticularly provides application of Gensci073 in preparation of medicines for improving food intake, promoting gastrointestinal motility and treating functional dyspepsia. Researches show that Gensci073 can obviously improve the gastric emptying rate and small intestine propulsion rate of a model rat, and the gastric emptying rate of an animal is reduced along with the increase of the administration dosage of Gensci073 and the small intestine propulsion rate of the animal is increased along with the increase of the administration dosage of Gensci073 within a measured range.

The invention provides application of a Mongolian medicine lomatogonium carinatum extract. The Mongolian medicine lomatogonium carinatum extract is applied to preparation of medicines for regulating intestines and stomach. According to a chemical component detection result of the lomatogonium carinatum extract, the swertiamarin with the highest content is selected, then the influence of the lomatogonium carinatum extract and the swertiamarin on gastric emptying and small intestine propulsion of mice is proved, and then DA and 5-HT are used for establishing a gastrointestinal motility disorder model; it is proved that the Mongolian medicine lomatogonium carinatum extract has a certain influence on neurotransmitter disorder gastrointestinal motility disorder diseases.

The invention belongs to the technical field of Chinese medicine, and particularly provides a medicine composition for treating constipation. The raw material medicines are composed of cistanche, bighead atractylodes rhizome and semen pruni, and the weight composition range is as follows: 5 to 50 parts of cistanche, 10 to 40 parts of bighead atractylodes rhizome and 10 to 40 parts of semen pruni. The invention further provides a preparation method and specific uses of the medicine composition. Proved by a pharmacological experiment, the medicine composition can obviously shorten first defecating time and increase defecating quantity, and testified by the mice carbon powder boosting experimental research, the medicine composition has the function of promoting small intestine wriggle.

The invention discloses a working starter product of Lactobacillus casei strain Qian (CCTCC No. M2013514) and its use for intestinal regulation diet therapy. .0 artificial gastric juice under treatment for 3 hours, the survival rate reached 62.51±7.35%. It can grow slowly under 1.0% concentration of bile salt, and the growth efficiency reaches 7.86±0.45% of the culture without bile salt. The hydrophobicity of Lactobacillus casei strain Qian cells It also reached 51.30±4.28%, and it grows normally in the human intestine; it can slow down the weight loss trend of mice caused by constipation, accelerate the time of black stool, improve the small intestinal propulsion rate, and lower the gene expression level of TRPV1 and NOS in mice , to reduce the defecation volume, the number of defecation particles, and the trend of decreasing the water content of feces, which has a similar effect to constipation drugs, showing a certain effect of preventing constipation.

The invention discloses a medicine for treating chronic constipation. The medicine is prepared from 15 g of radix angelicae sinensis, 12 g of radix astragali, 10 g of pericarpium citri reticulatae viride, 10 g of fructus aurantii, 6 g of rhubarb, 20 g of semen cassiae, 3 g of lotus leaves, 15 g of radix codonopsis, 15 g of stir-fried rhizoma atractylodis macrocephalae, 15 g of radix paeoniae alba, 10 g of rhizoma ligustici wallichi and 15 g of rhizoma polygonati. Radix angelicae sinensis can promote blood circulation and replenish blood and can be used for treating patients suffering from blood-deficiency constipation; radix codonopsis can replenish qi and nourish blood; radix astragali can replenish lung qi and tonify the spleen; the stir-fried rhizoma atractylodis macrocephalae can invigorate the spleen, replenish qi and soothe the mind and is used for treating patients suffering from qi-deficiency constipation; pericarpium citri reticulatae viride can relieve stagnant qi and disintegrate lumps, fructus aurantii can promote qi circulation and remove mites, and pericarpium citri reticulatae viride and fructus aurantii can promote peristalsis of small intestines of patients who suffer from gastroparesis resulting from diabetics when used together; rhubarb can eliminate turbidity by purgation and can also promote peristalsis of large intestines together with the lotus leaves; radix paeoniae alba and rhizoma ligustici wallichi can relieve pain, soothe the liver and promote blood circulation and are used for treating qi-depression constipation caused by depressed emotions; rhizoma polygonati can replenish qi and blood in the lung, the spleen and the kidney and has a beneficial effect on patients suffering from qi-deficiency constipation and blood-deficiency constipation; semen cassiae can moisten the intestines and relax the bowels.

The invention discloses a Chinese medicine for constipation treatment, belonging to the pharmaceutical field in Chinese medicine. The following eleven ingredients of radix angelicae sinensis, desertliving cistanche, asparagus cochinchinensis, rhizoma cimicifugae, rhizoma imperatae, rhizoma polygoni cuspidate, semen platycladi, fructus mori, fructus aurantii immaturus, hawthorn fruit and semen juglandis are used for preparing the medicine to be a capsule according to the conventional preparation technology. The medicine has the functions of softening hard mass, moistening the intestine and relaxing the bowels, invigorating the spleen and tonifying the kidney, which can treat constipation or defecation fatigue, lusterless complexion or iron-deficiency anemia, mental weariness and short breath, dizziness and blurred vision, soreness of the waist and knees, and the like. To further describe the benefits of the Chinese medicine, a mouse test is carried out to inspect the influence of the capsule on the bowel movement and the defecation time and amount of the mouse, presenting that the Chinese medicine of the invention with obvious laxative effect has the effects of improving the small intestine peristalsis, expanding the large intestine capacity and loosening the bowels.