Application of Mongolian medicine lomatogonium carinatum extract

The technology of a kind of styriflora and extract is applied in the application field of Mongolian medicine stylophora extract, and can solve the problem that the mechanism of action has not been reported and the like

Pending Publication Date: 2021-11-02
INNER MONGOLIA UNIV FOR THE NATITIES
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its mechanism of action has not been reported

Method used

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  • Application of Mongolian medicine lomatogonium carinatum extract
  • Application of Mongolian medicine lomatogonium carinatum extract
  • Application of Mongolian medicine lomatogonium carinatum extract

Examples

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Effect test

Embodiment 1

[0040] This embodiment relates to the application of the Mongolian medicine Stylodylum japonica extract, and the effect of the Mongolian medicine Stylostyle flower extract on gastric emptying and small intestine propulsion in mice.

[0041] 1. Effects on gastric emptying and small intestine propulsion in normal mice

[0042] 18 mice were randomly divided into 3 groups, 6 in each group;

[0043] Respectively: the normal control group, the low-dose group of Licorice flower extract (1g·kg -1 ), high-dose group (4g·kg -1 ).

[0044] The specific steps are: 0.1 mL·10 g of the corresponding drug solution is given to each drug group by intragastric administration. -1 , the normal control group was given an equal volume of CMC-Na solution. All groups were fasted before administration, without water for 16 hours. 5 minutes after administration on the second day, the blue semi-solid nutrient paste was administered into the stomach, with a volume of 0.5 mL per mouse. After 10 minute...

Embodiment 2

[0056] This embodiment relates to the application of the Mongolian medicine Stylodylum japonica extract, and the research on the effect of the Mongolian medicine Stylostyle flower extract on the isolated small intestinal smooth muscle.

[0057] Firstly, the Organ bath technology was used to screen each fragment of the mouse small intestine, and the small intestine fragment with high contractile activity was selected. Then according to the test results of the chemical components in Chapter 2, select swertiamarin (ST), swertiroside (SO), geniposidic acid (GA), hesperetin (HP) and hydroxyarginine with higher content. Five kinds of chemical components such as bean element (HC) were used to verify the effect of the extract of Mongolian medicine Riposte flower and its five chemical components on the isolated ileal smooth muscle. Using Ach and CaCl 2 Pretreatment of ileal smooth muscle leads to spastic contraction, and clarifies the effect of styloid flower extract and active ingred...

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Abstract

The invention provides application of a Mongolian medicine lomatogonium carinatum extract. The Mongolian medicine lomatogonium carinatum extract is applied to preparation of medicines for regulating intestines and stomach. According to a chemical component detection result of the lomatogonium carinatum extract, the swertiamarin with the highest content is selected, then the influence of the lomatogonium carinatum extract and the swertiamarin on gastric emptying and small intestine propulsion of mice is proved, and then DA and 5-HT are used for establishing a gastrointestinal motility disorder model; it is proved that the Mongolian medicine lomatogonium carinatum extract has a certain influence on neurotransmitter disorder gastrointestinal motility disorder diseases.

Description

technical field [0001] The invention belongs to the field of Mongolian medicine japonica extract, and in particular relates to an application of the Mongolian medicine japonica extract. Background technique [0002] Riposte flower is a characteristic medicinal material of Mongolian medicine. It tastes extremely bitter and has the effects of calming "Xie Ri", invigorating the stomach, healing wounds, and clearing away heat. day" and other diseases. Costa japonica is also the main traditional medicine of Mongolian medicine to treat liver and gallbladder diseases. It has been shown to be therapeutic for indigestion, swollen gallbladder, jaundice, and inflammation of the liver and gallbladder. Then it was found that the flavonoids of the Mongolian medicine Costa japonica have the functions of lowering blood fat and treating obesity. In addition, studies have reported that the Gentianaceae plant Swertia is a traditional medicine for treating gastrointestinal diseases such as ...

Claims

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Application Information

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IPC IPC(8): A61K36/51A61P1/00A61P1/14A61K133/00
CPCA61K36/51A61P1/00A61P1/14A61K2236/15A61K2236/333A61K2236/39A61K2236/53A61K2236/51
Inventor 付明海阿丽沙
Owner INNER MONGOLIA UNIV FOR THE NATITIES
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