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Novel use of cathartic formula with five fruits and vegetables as raw materials to increase gastrointestinal peristalsis and promote gastrointestinal emptying

A technology of gastrointestinal motility and new application, applied in the fields of application, plant raw materials, medical raw materials derived from fungi, etc., can solve the problems of serious constipation, destroying the flora structure, and being unsuitable for constipation.

Pending Publication Date: 2020-05-29
HEBEI YUZHILIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These cathartics act like high-pressure water guns in our intestines. Although they can take away the stool, they will also take away the probiotics in the intestines and destroy the flora structure in the intestines. Once they are stopped, constipation will occur. It is more serious, and long-term use will cause more intestinal diseases
[0034] 3. Products based on traditional Chinese medicine are not suitable for all types of constipation due to the limitations of the population using Chinese medicinal materials

Method used

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  • Novel use of cathartic formula with five fruits and vegetables as raw materials to increase gastrointestinal peristalsis and promote gastrointestinal emptying
  • Novel use of cathartic formula with five fruits and vegetables as raw materials to increase gastrointestinal peristalsis and promote gastrointestinal emptying
  • Novel use of cathartic formula with five fruits and vegetables as raw materials to increase gastrointestinal peristalsis and promote gastrointestinal emptying

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1 pharmacological experiment

[0046] Mesenchymal cells are those cells present in this organ that assist the parenchymal cells in carrying out the functions of the organ. For example, neuron cells in the brain are parenchymal cells, and glial cells play the role of supporting and nourishing nerve cells, which are regarded as interstitial cells. Support role.

[0047] ICC is a special type of mesenchymal cell between the enteric nervous system and smooth muscle cells, and is the pacemaker cell of the gastrointestinal tract, which generates and conducts slow waves, and the slow waves determine the direction and frequency of gastrointestinal peristaltic wave propagation and speed. It is an important part of regulating gastrointestinal motility. Moreover, in clinical studies, it was found that the number and volume of intestinal ICC decreased in patients with slow transit constipation. Therefore, increasing the number of ICC and restoring its normal shape an...

Embodiment 2

[0067] Example 2 Pharmacological Experiment of Gastrointestinal Empty Rate of Biaotong Tiantian Capsules

[0068] 1 material

[0069] 1.1 Drugs: Domperidone Tablets, Changtong Tiantian Capsules

[0070] Semi-solid nutritional paste: Dissolve 10g of carboxymethylcellulose sodium (CMC-Na) in 200mL of distilled water, add 16g of milk powder, 8g of sugar, 8g of starch, 4ml of carbon ink and distilled water, stir well, and prepare 300mL of black semi-solid paste

[0071] 2.1 Animals: SD rats (young mice), raised in SPF environment, room temperature 20-26°C

[0072] 2 methods

[0073] 2.1 Grouping and administration

[0074] 7 days after birth, 50 healthy male SD rats (juvenile mice) were acclimatized for 3 days. On the 10th day after birth, SD male pups were randomly divided into blank group, model group, Tiantian capsule low-dose group (36mg / kg), Tiantian capsule high-dose group (72mg / kg), domperidone group (3mg / kg), each group 10 rats, the rats in the blank group were given...

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Abstract

The invention provides a novel use of a cathartic formula with five fruits and vegetables as raw materials, and especially use of a cathartic formula with five fruits and vegetables as raw materials in preparation of foods or medicines for increasing gastrointestinal peristalsis and promoting gastrointestinal emptying. The cathartic formula is "Baitong" Tiantian Capsule composed of pumpkin, aloe,poria cocos, tremella fucifamis and xylooligosaccharide with a fineness of 5-20 mum. Studies show that the "Baitong" Tiantian Capsule can accelerate gastrointestinal transmission, increase gastrointestinal peristalsis, and promote gastrointestinal emptying, and increase gastric emptying rate and small intestinal propulsion rate in FD rats in a dose-dependent manner, provides a new method for enhancing gastric peristalsis and promoting gastrointestinal emptying, and has broad clinical application prospects.

Description

technical field [0001] The invention relates to a laxative prescription and its new application, belonging to the field of traditional Chinese medicine. Background technique [0002] 1. The gastrointestinal function of healthy people is definitely better, otherwise, the body will not be so good. Healthy gastrointestinal function depends on whether the ability of gastrointestinal motility is normal. If the gastrointestinal motility is not or slow, it will affect health. The peristalsis of the large intestine is when food enters the large intestine after being digested and waits to be excreted from the body. [0003] Many people don't feel hungry at all when it's time to eat, and they don't want to eat even the most delicious food. They become very picky about their appetite, and often feel tired and weak, with indigestion in their stomachs. This is mainly because many people don’t feel hungry at all when they eat, and they don’t want to eat even the most delicious food. The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K36/886A61K9/48A61P1/14A23L33/10A61K31/702
CPCA61K36/42A61K36/896A61K36/886A61K36/076A61K36/07A61K31/702A61K9/48A61P1/14A23L33/10A23V2002/00A61K2300/00A23V2200/32
Inventor 朱志铭赵大鹏张赞李积珍史志勋
Owner HEBEI YUZHILIN PHARMA
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